Epoetin beta

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Clinical Pharmacology

Eralfon - a treatment for anemia.
Epoetin alfa, a glycoprotein that specifically stimulates erythropoiesis, activates mitosis and maturation of erythrocytes from erythrocyte progenitor cells.
In its composition, biological and immunological properties of epoetin alfa is identical to the natural human erythropoietin.

The introduction of epoetin alfa leads to an increase in hemoglobin and hematocrit, improving the blood supply to the tissues and heart function. The most pronounced effect of the use of epoetin alfa is observed with anemia caused by chronic renal failure.

Indications

- anemia in patients with chronic renal failure, including those on hemodialysis;

- prevention and treatment of anemia in patients with solid tumors, anemia in which was the result of antitumor therapy;

- prevention and treatment of anemia in patients infected with human immunodeficiency virus (HIV), caused by the use of zidovudine, when the level of endogenous erythropoietin is less than 500 IU / ml;

- prevention and treatment of anemia in patients with myeloma, low-grade non-Hodgkins lymphomas, chronic lymphatic leukemia, in patients with rheumatoid arthritis;

- treatment and prevention of anemia in premature babies born with low body weight up to 1.5 kg;

- as part of a pre-posit program before extensive surgery in patients with a hematocrit of 33-39%, to facilitate the collection of autologous blood and reduce the risk associated with the use of allogeneic blood transfusions, if the expected need for transfused blood exceeds the amount that can be obtained by autologous collection without the use of epoetin alfa;

- before carrying out an extensive operation with the expected blood loss of 900-1800 ml in adult patients without anemia or with mild and moderate anemia (hemoglobin level 100-130 g / l) to reduce the need for allogeneic hemotransfusions and facilitate the recovery of erythropoiesis.

Composition

1 ampoule (1 ml) contains Epoetin alfa (REPOETIN-SP - human recombinant erythropoietin) as active substance 10,000 IU.

Excipients: albumin solution, sodium citrate pentasesquihydrate or sodium citrate dihydrate, sodium chloride, citric acid monohydrate, water for injection

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