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Etoksidol is an inhibitor of free radical processes, has a membrane-protective, antihypoxic, nootropic, anticonvulsant, anxiolytic effect, increases the body's resistance to stress. Etoxydol has anti-ischemic properties, improves blood flow in the ischemic zone, limits the zone of ischemic damage, detects a lipid-lowering effect, reduces the content of total cholesterol and low-density lipoproteins.
The drug increases the body's resistance to the effects of various damaging factors, to oxygen-dependent pathological conditions (shock, hypoxia, ischemia, cerebral circulation disorders, alcohol intoxication and antipsychotics (neuroleptics)). Etoxydol is able to modulate the functional-metabolic state of red blood cells, adjust the functional status of the liver and kidneys.
Restoring the activity of the synthesis of a macroergic metabolite of 2,3-diphosphoglycerate, the drug increases the dissociation of oxyhemoglobin and restores oxygen tension.
The effectiveness of this drug for encephalopathy is due to an increase in oxygen in arterial blood; penetration of Etoxydol through the blood-brain barrier.
The drug improves brain metabolism and blood supply to the brain, improves microcirculation and rheological properties of blood, reduces platelet aggregation. Stabilizes the membrane structure of blood cells (erythrocytes and platelets) during hemolysis.
The mechanism of action of the drug due to its antioxidant, antihypoxic and membrane-protective action. It inhibits lipid peroxidation, increases the activity of superoxide dismutase, reduces the content of total organic peroxides, helps accelerate the metabolism of aldosterone (by normalizing the activity of the CYP3A4 isoenzyme), increases the ratio of lipid proteins, reduces the viscosity of the membrane, increases its fluidity. By suppressing peroxides and oxidant activity, it blocks the oxidation of β-lipoproteins (low density lipoproteins), which are the main substrate for the formation of atherosclerotic plaques in blood vessels. Modulates the activity of membrane-bound enzymes (calcium-independent phosphodiesterase, adenylate cyclase, acetylcholinesterase), receptor complexes (benzodiazepine, GABA, acetylcholine), which enhances their ability to bind to ligands, helps to preserve the structural and functional organization of biomembrane, and the use of the use of in-route flow patterns.
With intramuscular administration of ethylmethylhydroxypyridine malate is determined in the blood plasma for 4 hours after administration. The time to reach the maximum concentration is 0.25 hours. The maximum concentration at a dose of 100 mg is 0.3-1.06 mcg / ml. Ethyl methyl hydroxypyridine malate is rapidly transferred from the bloodstream to organs and tissues and is rapidly eliminated from the body. The retention time of ethyl methyl hydroxypyridine malate (MRT) is 1.84-2.38 hours. The elimination half-life is 1.15-1.75 h. Ethyl methyl hydroxypyridine malate is excreted by the kidneys, mainly in glucuron conjugated form and in small quantities in unchanged form.
- acute disorders of cerebral circulation;
- vegetative dystonia syndrome;
- mild cognitive impairment of atherosclerotic genesis;
- anxiety disorders in neurotic and neurosis-like conditions;
- relief of withdrawal syndrome in alcoholism with a predominance of neurosis-like and vegetative-vascular disorders;
- acute intoxication with antipsychotics
Active ingredient: ethylmethylhydroxypyridine malate (ethoxydol) - 50 mg.
Excipients: N-acetyl-L-glutamic acid - 34 mg, deaiol (2- (dimethylamino) ethanol) - 16 mg, glycine - 0.1 mg, disodium edetate (disodium ethylenediamine-N, N, N salt) '-tetraacetic acid 2-water [Trilon B]) - 0.5 mg, water for injection - up to 1.0 ml.
Ethoxydol is marketed under different brands and generic names, and comes in different dosage forms:
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Dosage and Administration
Etoxydol is prescribed intramuscularly and intravenously (jet or drip). When the infusion method of administration of the drug should be diluted in 0.9% sodium chloride solution. Doses are selected individually. Begin therapy with a dose of 50-100 mg 1-3 times a day, gradually increasing to obtain a therapeutic effect. Jet Etoxidol is injected slowly over 5-7 minutes, drip - at a speed of 40-60 drops per minute. The maximum daily dose should not exceed 800 mg.
For acute disorders of cerebral circulation, Etoxidol is prescribed in the complex therapy for the first 2-4 days intravenously (drip) at a dose of 200-300 mg, then intramuscularly 100 mg 3 times a day. Duration of treatment is 10-14 days.
When dyscirculatory encephalopathy in the phase of decompensation, ethoxydol is administered intravenously in a stream or drip at a dose of 100 mg 2-3 times a day for 14 days. Then - intramuscularly on 100 mg 2 times a day for 14 days.
For course prophylaxis of dyscirculatory encephalopathy, the drug is administered intramuscularly at a dose of 100 mg 2 times a day for 10-14 days.
For mild cognitive impairment in elderly patients and for anxiety disorders, the drug is used intramuscularly in a daily dose of 100-300 mg / day for 14-30 days.
With alcohol withdrawal, ethoxydol is administered intramuscularly at a dose of 100-200 mg 2-3 times a day or intravenously drip 1-2 times a day for 5-7 days.
In acute intoxication with antipsychotics, the drug is administered intravenously at a dose of 50-300 mg per day for 7-14 days.
- "Metallic" taste in the mouth,
- sensations of "overflowing heat" in the whole body,
- unpleasant smell
- sore throat and chest discomfort,
- feeling of lack of air (usually associated with an excessively high rate of administration and are short-lived);
- with prolonged use - nausea, flatulence; sleep disturbances (drowsiness or sleep disturbance).
- Hypersensitivity to the drug Etoxidol or its components,
- lactation period
- age up to 18 years.
Enhances the action of benzodiazepine anxiolytics, anticonvulsants (carbamazepine), anti-parkinsonian drugs (levodopa). Reduces the toxic effects of ethyl alcohol.
Pregnancy and Lactation
Etoxydol is contraindicated during pregnancy and lactation, as there are no strictly controlled clinical studies on the safety of the drug during pregnancy and lactation.
During the period of treatment, care must be taken when driving and engaging in other potentially hazardous activities that require increased concentration and psychomotor speed.
Symptoms: sleep disturbances (insomnia, in some cases drowsiness); with intravenous administration - a slight and short-term (up to 1.5-2 h) increase in blood pressure.
LOCATION: as a rule, it is not required - the symptoms disappear on their own within a day. In severe cases of insomnia, nitrazepam 10 mg, oxazepam 10 mg or diazepam 5 mg. With an excessive increase in blood pressure - antihypertensive drugs under the control of blood pressure.