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Etoksidol is an inhibitor of free radical processes, has a membrane-protective, antihypoxic, nootropic, anticonvulsant, anxiolytic effect, increases the body's resistance to stress. Etoxydol has anti-ischemic properties, improves blood flow in the ischemic zone, limits the zone of ischemic damage, detects a lipid-lowering effect, reduces the content of total cholesterol and low-density lipoproteins.
The drug increases the body's resistance to the effects of various damaging factors, to oxygen-dependent pathological conditions (shock, hypoxia, ischemia, cerebral circulation disorders, alcohol intoxication and antipsychotics (neuroleptics)). Etoxydol is able to modulate the functional-metabolic state of red blood cells, adjust the functional status of the liver and kidneys.
Restoring the activity of the synthesis of a macroergic metabolite of 2,3-diphosphoglycerate, the drug increases the dissociation of oxyhemoglobin and restores oxygen tension.
The effectiveness of this drug for encephalopathy is due to an increase in oxygen in arterial blood; penetration of Etoxydol through the blood-brain barrier.
The drug improves brain metabolism and blood supply to the brain, improves microcirculation and rheological properties of blood, reduces platelet aggregation. Stabilizes the membrane structure of blood cells (erythrocytes and platelets) during hemolysis.
The mechanism of action of the drug due to its antioxidant, antihypoxic and membrane-protective action. It inhibits lipid peroxidation, increases the activity of superoxide dismutase, reduces the content of total organic peroxides, helps accelerate the metabolism of aldosterone (by normalizing the activity of the CYP3A4 isoenzyme), increases the ratio of lipid proteins, reduces the viscosity of the membrane, increases its fluidity. By suppressing peroxides and oxidant activity, it blocks the oxidation of β-lipoproteins (low density lipoproteins), which are the main substrate for the formation of atherosclerotic plaques in blood vessels. Modulates the activity of membrane-bound enzymes (calcium-independent phosphodiesterase, adenylate cyclase, acetylcholinesterase), receptor complexes (benzodiazepine, GABA, acetylcholine), which enhances their ability to bind to ligands, helps to preserve the structural and functional organization of biomembrane, and the use of the use of in-route flow patterns.
With intramuscular administration of ethylmethylhydroxypyridine malate is determined in the blood plasma for 4 hours after administration. The time to reach the maximum concentration is 0.25 hours. The maximum concentration at a dose of 100 mg is 0.3-1.06 mcg / ml. Ethyl methyl hydroxypyridine malate is rapidly transferred from the bloodstream to organs and tissues and is rapidly eliminated from the body. The retention time of ethyl methyl hydroxypyridine malate (MRT) is 1.84-2.38 hours. The elimination half-life is 1.15-1.75 h. Ethyl methyl hydroxypyridine malate is excreted by the kidneys, mainly in glucuron conjugated form and in small quantities in unchanged form.
- acute disorders of cerebral circulation;
- vegetative dystonia syndrome;
- mild cognitive impairment of atherosclerotic genesis;
- anxiety disorders in neurotic and neurosis-like conditions;
- relief of withdrawal syndrome in alcoholism with a predominance of neurosis-like and vegetative-vascular disorders;
- acute intoxication with antipsychotics
Active ingredient: ethylmethylhydroxypyridine malate (ethoxydol) - 50 mg.
Excipients: N-acetyl-L-glutamic acid - 34 mg, deaiol (2- (dimethylamino) ethanol) - 16 mg, glycine - 0.1 mg, disodium edetate (disodium ethylenediamine-N, N, N salt) '-tetraacetic acid 2-water [Trilon B]) - 0.5 mg, water for injection - up to 1.0 ml.
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