FerInject® [Iron carboxymaltose]

IV - jet or drip and by introducing into the venous area dialysis system.

Before opening, the bottles should be inspected for possible sediment and damage. You can use only a homogeneous solution without sediment.
Drip introduction

You can not assign a drip of 20 ml of Ferinject more than 1 time per week.

May be administered intravenously in a drip in the maximum single dose of up to 20 ml of Ferinject (1000 mg of iron), which should not exceed 0.3 ml of Ferinject (15 mg of iron) per 1 kg of body weight or the calculated cumulative dose.

Jet injection

Ferinject can be administered intravenously, in a maximum single dose of up to 4 ml (200 mg of iron) per day, but not more than 3 times a week.

Dose calculation

The cumulative dose of the drug in mg of elemental iron, necessary to restore the level of hemoglobin (Hb) and replenish iron stores, is calculated individually in accordance with the general iron deficiency in the body using the formula:

Cumulative iron deficiency [mg] = body weight [kg] × (target Hb * - actual Hb) [g / dL] ** × 2.4 *** + iron storage depot [mg] ****
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* Target Hb with a body weight less than 35 kg = 13 g / dl (respectively 8.1 mmol / l). Target Hb with a body weight of 35 kg and more = 15 g / dl (respectively 9.3 mmol / l).

** To convert Hb [mM] to Hb [g / dl]: multiply Hb [mM] by a factor of 1.61145.

*** Coefficient 2.4 = 0.0034 × 0.07 × 10000, where:
0.0034 - hemoglobin iron content is approximately equal to 0.34%;
0.07 - blood volume is approximately equal to 7% of body weight;
10,000 - conversion factor: 1 g / dl = 10,000 mg / l.

**** Iron deposited with a body weight less than 35 kg = 15 mg / kg body weight; iron deposited with a body weight of 35 kg and more = 500 mg.

For patients ≤66 kg: the calculated cumulative dose of iron should be rounded down to the nearest 100 mg.
For patients> 66 kg: the calculated cumulative dose of iron should be rounded up to the nearest 100 mg.


With the subsequent need to maintain the target level of Hb and other laboratory indicators of iron reserves within acceptable limits, it is possible to continue treatment with the Ferinject drug in the minimum maintenance dose.
Maximum tolerated single dose

Adequate cumulative dose of the drug should be calculated for each patient individually and should not exceed the calculated one.

Contraindications

Hypersensitivity to any of the components of the drug.
Anemia not related to iron deficiency.
Symptoms of iron overload or iron disruption.
Pregnancy, I trimester.
Lactation period.
Children under 14 years old.

Drug interactions

Any parenteral iron preparations should not be administered simultaneously with oral dosage forms of iron, since This reduces the absorption of iron from the gastrointestinal tract.