Fibrovein® [Sodium tetradecyl sulfate]
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Clinical Pharmacology
Fibrovein has a venosklerosiruyuschee effect. When in contact with the endothelium causes a rapid coagulation of its proteins.
Indications
Various forms of lower limb varicose veins, including intradermal varicose veins and telangiectasias.
Composition
1 ml of an aqueous solution contains sodium tetradecyl sulfate 3 mg.
Sodium tetradecyl sulfate is marketed under different brands and generic names, and comes in different dosage forms:
Brand name | Manufacturer | Country | Dosage form |
---|---|---|---|
Fibrovein | STD Pharmaceutical | UK | ampoules |
Fibrovein | STD Pharmaceutical | UK | vials |
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Dosage and Administration
Fibrovein administered IV, into the lumen of the isolated segment of the empty superficial vein with its immediate long-term compression (the imposition of a compression band). The dosage is determined depending on the size of the vein subjected to hardening; usual dose - 1 ml (not more) in one place. For Fibro-Wein 0.2% - the maximum single dose up to 10 ml. If necessary, additional injections are performed after a 2-week break.
Adverse reactions
Local reactions: possible hyperemia of the skin, slight pain or a burning sensation at the injection site.
Allergic reactions: rarely occur.
Contraindications
Hypersensitivity to Fibrovein components, acute thrombophlebitis, acute thrombosis, arterial insufficiency of the lower extremities, hemorrhagic diathesis, local and general infection.
Drug interactions
Pharmaceutical incompatible with heparin. It is not recommended to combine with oral contraceptives (especially anti-ovulatory).
Special instructions
1. Fibrovein should be used by doctors who are familiar with the sclerotherapy technique. It is necessary to properly evaluate valvular insufficiency and deep vein condition.
2. Vein sclerosis is carried out with caution with absolute confidence in the patency of the deep and communicative veins of the lower extremities.
3. Before starting treatment, it is necessary to know the patient's allergic history. You can enter the patient 0,25-0,5 ml of Fibrovein for 24 hours before the start of treatment to identify a possible allergic reaction.
4. Care must be taken when treating patients with peripheral atherosclerosis, Buerger's disease.
5. Especially carefully you need to enter the drug in the area above and behind the medial ankle, because there is a posterior tibial artery.
6. Do not allow extravasal (paravenous) and intraarterial administration.
7. Do not use the drug in case of precipitation or discoloration of the solution.
8. When the temperature in the solution decreases, a precipitate may form that dissolves when heated.
9. To prevent relapse after treatment, patients are recommended to wear elastic stockings.
- Brand name: Fibrovein
- Active ingredient: Sodium tetradecyl sulfate
- Dosage form: Aqueous solution for injection.
- Manufacturer: STD Pharmaceutical
- Country of Origin: Great Britain
Studies and clinical trials of Sodium tetradecyl sulfate (Click to expand)
- The effect of sodium tetradecyl sulfate on mobility and antigen detectability of microtubule proteins in sodium dodecyl sulfate-polyacrylamide gel electrophoresis
- Enhanced growth of methane–propane clathrate hydrate crystals with sodium dodecyl sulfate, sodium tetradecyl sulfate, and sodium hexadecyl sulfate surfactants
- Comparative Trial Between Sodium Tetradecyl Sulfate and Glycerin in the Treatment of Telangiectatic Leg Veins
- Effect of intravenous and intraperivenous injections of sclerosants (sodium tetradecyl sulfate and hydroxy polyethoxy dodecan) on the rat femoral vein
- Transcatheter Foam Sclerotherapy of Symptomatic Female Varicocele with Sodium-Tetradecyl-Sulfate Foam
- Sclerosing therapy for orbital lymphangioma using sodium tetradecyl sulfate
- Sodium Tetradecyl Sulfate for Sclerotherapy Treatment of Veins: Is Compounding Pharmacy Solution Safe?
- Stability of Foam in Sclerotherapy: Differences between Sodium Tetradecyl Sulfate and Polidocanol and the Type of Connector Used in the Double-Syringe System Technique
- Double-Blind Prospective Comparative Trial between Foamed and Liquid Polidocanol and Sodium Tetradecyl Sulfate in the Treatment of Varicose and Telangiectatic Leg Veins
- FDA-Approved Sodium Tetradecyl Sulfate (STS) versus Compounded STS for Venous Sclerotherapy
- Subungual Pyogenic Granuloma Treated by Sodium Tetradecyl Sulfate Sclerotherapy
- Inadvertent Injection of Sodium Tetradecyl Sulfate During Placement of Mental Nerve Block: Discussion of Management and Outcome
- Angiokeratoma of Fordyce Treated with 0.5% Ethanolamine Oleate or 0.25% Sodium Tetradecyl Sulfate
- Interactions between sodium tetradecyl sulfate and a series of homogeneous polyoxyethyleneglycol- n- dodecyl ethers
- Comparative Analysis of Intralesional Sclerotherapy with Sodium Tetradecyl Sulfate Versus Bleomycin in the Management of Low Flow Craniofacial Soft Tissue Vascular Lesions
- Histological and biomechanical effects of palatal sclerotherapy in the horse using sodium tetradecyl sulfate
- Intralesional vinblastine vs. 3% sodium tetradecyl sulfate for the treatment of oral Kaposi’s sarcoma. A double blind, randomized clinical trial
- Cirsoid aneurysm treatment by percutaneous injection of sodium tetradecyl sulfate
- Treatment of Oral Hemangioma with 3% Sodium Tetradecyl Sulfate: Study of 20 Cases
- Re: postmarking adverse events related to sotradecol (sodium tetradecyl sulfate-sclerosing agent)
- Evaluation of the Role of Sodium Tetradecyl Sulfate as a Sclerosant in the Treatment of Primary Hydrocele
- Percutaneous Sodium Tetradecyl Sulfate Sclerotherapy for Peripheral Venous Vascular Malformations: A Single-Center Experience
- Sodium tetradecyl sulfate
- Portal vein embolization prior to right hepatectomy using sodium tetradecyl sulfate foam: technique and initial results