Flucoldex-N
Dump Pharma
1547 Items
2019-09-19
- done All payments are SSL encrypted
- done Full Refund if you haven't received your order
- done International shipping to the USA, UK and Europe
Clinical Pharmacology
Combined drug.
Caffeine has a moderate psychostimulant effect, temporarily reducing fatigue symptoms and drowsiness. Due to a combination of central and peripheral effects on the heart and blood vessels, the cardiovascular system is ambiguous: the coronary vessels, as a rule, dilate and the brain vessels tone up, the blood pressure rises somewhat (more often with initial hypotension).
Caffeine increases the basal metabolic rate, has a moderate myotropic antispasmodic effect (dilates the bronchi, biliary ducts), stimulates the secretion of the gastric glands, slightly increases diuresis.
The pharmacological properties of caffeine are due to its competitive antagonism with adenosine at the A1 level of adenosine receptors and the inhibition of PDE activity.
Paracetamol has an analgesic and antipyretic effect. These properties are due to inhibition in the central nervous system of the synthesis of prostaglandins - modulators of pain sensitivity and thermoregulation. Almost no anti-inflammatory effect.
Chlorphenamine - histamine H blocker1-receptors. In addition to the antiallergic effect, it has some local anesthetic, antispasmodic, anticholinergic, sedative and hypnotic effects. Effective with kinetozakh (motion sickness syndrome) and Meniere's disease.
Pharmacokinetics
Indications
- febrile syndrome (catarrhal and infectious diseases);
- pain syndrome of mild and moderate severity (arthralgia, myalgia, neuralgia, migraine, toothache and headache, algomenorrhea);
- pain with injuries, burns;
- sinusitis, rhinorrhea (acute rhinitis, allergic rhinitis).
Composition
1 tablet contains:
acting substances: paracetamol 500 mg, caffeine 30 mg, chlorphenamine maleate 2 mg.
No customer reviews for the moment.
Dosage and Administration
Pills take orally, 1 tablet 2-3 times a day at intervals of not less than 4 hours.
The maximum single dose for adults and children over 12 years old - 2 pills, daily - 8 pills.
Reception duration - no more than 5 days.
Increasing the daily dose of the drug or the duration of treatment is possible only under medical supervision.
Adverse reactions
Allergic reactions (skin rash, itching, urticaria, angioedema), nausea, epigastric pain.
Mydriasis, accommodation paresis, increased intraocular pressure, dryness of the mucous membrane of the mouth, nose, throat; urine retention.
With prolonged use in large doses - hepatotoxic effect, hemolytic or aplastic anemia, methemoglobinemia, thrombocytopenia, agranulocytosis, pancytopenia; nephrotoxicity (renal colic, glycosuria, interstitial nephritis, papillary necrosis).
Contraindications
With caution: congenital hyperbilirubinemia (Gilbert, Dubin-Johnson and Rotor syndromes), alcoholism, angle-closure glaucoma, prostatic hyperplasia, pregnancy, lactation; advanced age, child age (up to 12 years).
Drug interactions
NSAIDs and drugs that inhibit the central nervous system - may increase the side effects of the drug.
The risk of hepatotoxic action increases with the simultaneous appointment of barbiturates, phenytoin, carbamazepine, rifampicin, zidovudine and other inducers of liver microsomal enzymes, ethanol.
Reduces excretion and increases the toxicity of chloramphenicol.
Metoclopramide and domperidone increase the absorption rate of paracetamol, colestyramine - slows down.
Simultaneous administration with indirect anticoagulants should be carried out under constant medical supervision.
Pregnancy and Lactation
With caution: pregnancy, lactation.
Special instructions
Excessive consumption of tea, coffee and other products containing methylxanthines should be avoided.
In order to avoid the hepatotoxic effects of paracetamol, ethanol should not be consumed during the treatment period.
With prolonged (more than 1 week) use of the drug, it is necessary to control the picture of peripheral blood and the functional state of the liver.
Influence on ability to drive motor transport and control mechanisms
During the period of treatment, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and psychomotor speed.
Overdosage
Symptoms (caused by paracetamol): pale skin, loss of appetite, nausea, vomiting; hepatonecrosis (severity of necrosis due to intoxication directly depends on the degree of overdose). Toxic effects in adults are possible after administration of more than 10-15 g of paracetamol: an increase in the activity of hepatic transaminases, an increase in prothrombin time (12-48 hours after administration); A detailed clinical picture of liver damage occurs after 1-6 days. Rarely, liver failure develops with lightning speed and may be complicated by renal failure (tubular necrosis).
Treatment: the introduction of SH-group donators and precursors of the synthesis of glutathione - methionine - 8-9 hours after an overdose, and N-acetylcysteine - 12 hours later.
The need for additional therapeutic measures (the further introduction of methionine, IV the introduction of N-acetylcysteine) is determined depending on the concentration of paracetamol in the blood, as well as the time elapsed after taking it.
- Brand name: Flucoldex-N
- Active ingredient: Caffeine, Paracetamol, Chlorphenamine
- Dosage form: Flucoldex N. pills.
- Manufacturer: Dump Pharma
- Country of Origin: India
8 other products in the same category:
arrow_upward