Buy Sinaflan® ointment 0.025%, 15 g
  • Buy Sinaflan® ointment 0.025%, 15 g

Fluocinolone acetonide

Nizhpharm
908 Items
2019-09-19
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$33.75
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Clinical Pharmacology

Glucocorticosteroid for external use. It has anti-inflammatory, anti-allergic, anti-exudative and antipruritic action. Reduces manifestations and eliminates inflammatory skin reaction.

Suggested use

Topically. A small amount of the drug is applied 2-4 times a day and lightly rubbed onto the skin previously cleaned with a tampon moistened with an antiseptic liquid. If necessary, you can apply an occlusive dressing, leaving it on the affected surface for up to 3-4 days. It is not allowed to apply under the dressing more than 2 grams per day. The duration of treatment depends on the nature of the disease and is usually 5-10 days, with a long course of the disease up to 25 days. Ointment is preferable to use with dry forms of dermatosis.

Indications

Eczema, atopic dermatitis, simple chronic lichen (limited neurodermatitis), toksidermiya, simple allergic dermatitis, seborrheic dermatitis, pruritus, urticaria, scratching, diaper rash, erythema multiforme, psoriasis (exudative form); lichen planus, discoid lupus erythematosus, dyshidrosis of the hands, otitis externa, first degree burns, insect bites.

Composition

1 g of ointment contains: active ingredient: fluocinolone acetonide (sinaflan) - 0.25 mg, excipients: propylene glycol - 49.75 mg, ceresin - 50.00 mg, lanolin - 50.00 mg, petroleum jelly - up to 1.0 g .

Fluocinolone acetonide is marketed under different brands and generic names, and comes in different dosage forms:

Brand nameManufacturerCountryDosage form
Sinaflan® Nizhpharm Russia ointment
Flucinar® Elfa Pharmaceutical Plant Poland gel
Flucinar® Elfa Pharmaceutical Plant Poland ointment

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Fluocinolone acetonide

Dosage and Administration

Topically. A small amount of the drug is applied 2-4 times a day and lightly rubbed onto the skin previously cleaned with a tampon moistened with an antiseptic liquid. If necessary, you can apply an occlusive dressing, leaving it on the affected surface for up to 3-4 days. It is not allowed to apply under the dressing more than 2 grams per day. The duration of treatment depends on the nature of the disease and is usually 5-10 days, with a long course of the disease up to 25 days. Ointment is preferable to use with dry forms of dermatosis.

Adverse reactions

Perhaps the development of secondary infectious skin lesions and atrophic changes in it (burning, itching, dry skin, steroid acne, folliculitis). With prolonged use - hypertrichosis, alopecia, especially in women, secondary immunodeficiency (exacerbation of chronic infectious diseases, generalization of infectious process, the development of opportunistic infections); skin atrophy, local hirsutism, telangiectasia, purpura, pigmentation disorders. When applied to extensive surfaces, systemic manifestations are possible (gastritis, "steroid" gastric ulcer, adrenal insufficiency, Itsenko-Cushing's syndrome, "steroid" diabetes, slow reparative processes).

Contraindications

Hypersensitivity to the drug; bacterial, viral, fungal skin diseases - pyoderma, chicken pox, herpes, actinomycosis, blastomycosis, sporotrichosis; skin manifestations of syphilis, skin tuberculosis, diaper rash, acne rosacea, extensive psoriatic eruptions (plaques), anogenital itching; trophic ulcers of the leg associated with varicose veins, erosive and ulcerative lesions of the gastrointestinal tract, wounds in the areas of application; skin cancer, nevus, atheroma, melanoma, hemangioma, xanthoma, sarcoma; pregnancy and lactation, child age (up to 2 years). With caution used in girls during puberty.

Drug interactions

Compatible with antimicrobial agents. Reduces the activity of antihypertensives, diuretics, antiarrhythmic drugs, potassium preparations. Diuretic drugs (except potassium-sparing) increase the risk of hypokalemia.

Pregnancy and Lactation

Contraindicated in pregnancy and lactation.

Special instructions

Apply only short courses on small areas of the skin. The drug should not be applied to the face. Avoid contact with eyes. The duration of the appointment in children should not exceed 5 days. Wear free clothing during treatment. Patients with ordinary or pink acne with the treatment may have an exacerbation of the disease. To prevent local infectious complications, it is recommended to prescribe it in combination with antimicrobial agents. Without a prescription.

Overdosage

Symptoms: itching, burning of the skin at the site of application of the ointment, hyperglycemia, glycosuria, Itsenko-Cushing syndrome.
Treatment: symptomatic against the background of gradual withdrawal of the drug.

  • Brand name: Sinaflan®
  • Active ingredient: Fluocinolone acetonide
  • Dosage form: Ointment for external use.
  • Manufacturer: Nizhpharm
  • Country of Origin: Russia

Studies and clinical trials of Fluocinolone acetonide (Click to expand)

  1. Therapy of mycosis fungoides with topically applied fluocinolone acetonide under occlusive dressing
  2. Preparation of high specific activity tritium labeled 6α,9,-difluoro-11β,21-dihydroxy-16α,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-one, fluocinolone acetonide
  3. Effect of topical vehicle composition on the in vitro release of fluocinolone acetonide and its acetate ester
  4. An application of second-order UV-derivative spectrophotometry for study of solvolysis of a novel fluocinolone acetonide ester
  5. Base catalysed rearrangement of fluocinolone acetonide to a 17α-pregnane-21,16α-carbolactone
  6. Solid-state investigation of fluocinolone acetonide
  7. Clinical evaluation in treatment of oral lichen planus with topical fluocinolone acetonide: a 2-year follow-up
  8. Topical formulations of fluocinolone acetonide
  9. EFFECTS OF FLUOCINOLONE ACETONIDE CREAM ON THE SKIN WINDOW RECORD OF INFLAMMATORY EXUDATES.
  10. EFFECT OF FLUOCINOLONE ACETONIDE CREAM ON HUMAN SKIN BLOOD FLOW.
  11. FLUOCINOLONE ACETONIDE. A New Steroid Preparation for Topical Use.
  12. TREATMENT OF CHRONIC DISCOID LUPUS ERYTHEMATOSUS WITH FLUOCINOLONE ACETONIDE OINTMENT.
  13. THE EFFECT OF PAKTICLE SIZE AND VEHICLE ON THE PERCUTANEOUS ABSORPTION OF FLUOCINOLONE ACETONIDE.
  14. THE EFFECT OF FORMULATION ON THE CLINICAL RESPONSE TO TOPICAL FLUOCINOLONE ACETONIDE.
  15. PLASMA CORTISOL LEVELS AFTER TOPICAL USE OF FLUOCINOLONE ACETONIDE.
  16. A COMPARISON OF 0·1% BETAMETHASONE VALERATE AND 0·1% FLUOCINOLONE ACETONIDE IN THE TREATMENT OF PSORIASIS.
  17. FLUOCINOLONE ACETONIDE 0·2% CREAM—A CO-OPERATIVE CLINICAL TRIAL
  18. A dimethoxynaphthalene derivative (RS-43179 gel) compared with 0.025% fluocinolone acetonide gel in the treatment of psoriasis
  19. A randomized controlled trial of the efficacy and safety of a fixed triple combination (fluocinolone acetonide 0·01%, hydroquinone 4%, tretinoin 0·05%) compared with hydroquinone 4% cream in Asian patients with moderate to severe melasma
  20. TRAITEMENT OCCLUSIF DES DERMATITIS HERPÉTIFORMES, DES AFFECTIONS PEMPHIGÖIDES ET DU PEMPHIGUS VULGAIRE PAR L'ACETONIDE FLUOCINOLONE
  21. TOPICAL TREATMENT OF DERMATITIS HERPETIFORMIS WITH BETAMETHASONE-17-VALERATE AND FLUOCINOLONE ACETONIDE
  22. Fluocinolone Acetonide 0.01% in Peanut Oil: Safety and Efficacy Data in the Treatment of Childhood Atopic Dermatitis in Infants as Young as 3 Months of Age
  23. Contact sensitivity to betamethasone 17-valerate and fluocinolone acetonide
  24. Relative efficacy of fluocinolone acetonide compared with triamcinolone acetonide in treatment of oral lichen planus

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