Fluocinolone acetonide
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Clinical Pharmacology
Glucocorticosteroid for external use. It has anti-inflammatory, anti-allergic, anti-exudative and antipruritic action. Reduces manifestations and eliminates inflammatory skin reaction.
Suggested use
Topically. A small amount of the drug is applied 2-4 times a day and lightly rubbed onto the skin previously cleaned with a tampon moistened with an antiseptic liquid. If necessary, you can apply an occlusive dressing, leaving it on the affected surface for up to 3-4 days. It is not allowed to apply under the dressing more than 2 grams per day. The duration of treatment depends on the nature of the disease and is usually 5-10 days, with a long course of the disease up to 25 days. Ointment is preferable to use with dry forms of dermatosis.
Indications
Eczema, atopic dermatitis, simple chronic lichen (limited neurodermatitis), toksidermiya, simple allergic dermatitis, seborrheic dermatitis, pruritus, urticaria, scratching, diaper rash, erythema multiforme, psoriasis (exudative form); lichen planus, discoid lupus erythematosus, dyshidrosis of the hands, otitis externa, first degree burns, insect bites.
Composition
1 g of ointment contains: active ingredient: fluocinolone acetonide (sinaflan) - 0.25 mg, excipients: propylene glycol - 49.75 mg, ceresin - 50.00 mg, lanolin - 50.00 mg, petroleum jelly - up to 1.0 g .
Fluocinolone acetonide is marketed under different brands and generic names, and comes in different dosage forms:
Brand name | Manufacturer | Country | Dosage form |
---|---|---|---|
Sinaflan® | Nizhpharm | Russia | ointment |
Flucinar® | Elfa Pharmaceutical Plant | Poland | gel |
Flucinar® | Elfa Pharmaceutical Plant | Poland | ointment |
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Dosage and Administration
Topically. A small amount of the drug is applied 2-4 times a day and lightly rubbed onto the skin previously cleaned with a tampon moistened with an antiseptic liquid. If necessary, you can apply an occlusive dressing, leaving it on the affected surface for up to 3-4 days. It is not allowed to apply under the dressing more than 2 grams per day. The duration of treatment depends on the nature of the disease and is usually 5-10 days, with a long course of the disease up to 25 days. Ointment is preferable to use with dry forms of dermatosis.
Adverse reactions
Perhaps the development of secondary infectious skin lesions and atrophic changes in it (burning, itching, dry skin, steroid acne, folliculitis). With prolonged use - hypertrichosis, alopecia, especially in women, secondary immunodeficiency (exacerbation of chronic infectious diseases, generalization of infectious process, the development of opportunistic infections); skin atrophy, local hirsutism, telangiectasia, purpura, pigmentation disorders. When applied to extensive surfaces, systemic manifestations are possible (gastritis, "steroid" gastric ulcer, adrenal insufficiency, Itsenko-Cushing's syndrome, "steroid" diabetes, slow reparative processes).
Contraindications
Hypersensitivity to the drug; bacterial, viral, fungal skin diseases - pyoderma, chicken pox, herpes, actinomycosis, blastomycosis, sporotrichosis; skin manifestations of syphilis, skin tuberculosis, diaper rash, acne rosacea, extensive psoriatic eruptions (plaques), anogenital itching; trophic ulcers of the leg associated with varicose veins, erosive and ulcerative lesions of the gastrointestinal tract, wounds in the areas of application; skin cancer, nevus, atheroma, melanoma, hemangioma, xanthoma, sarcoma; pregnancy and lactation, child age (up to 2 years). With caution used in girls during puberty.
Drug interactions
Compatible with antimicrobial agents. Reduces the activity of antihypertensives, diuretics, antiarrhythmic drugs, potassium preparations. Diuretic drugs (except potassium-sparing) increase the risk of hypokalemia.
Pregnancy and Lactation
Contraindicated in pregnancy and lactation.
Special instructions
Apply only short courses on small areas of the skin. The drug should not be applied to the face. Avoid contact with eyes. The duration of the appointment in children should not exceed 5 days. Wear free clothing during treatment. Patients with ordinary or pink acne with the treatment may have an exacerbation of the disease. To prevent local infectious complications, it is recommended to prescribe it in combination with antimicrobial agents. Without a prescription.
Overdosage
Symptoms: itching, burning of the skin at the site of application of the ointment, hyperglycemia, glycosuria, Itsenko-Cushing syndrome.
Treatment: symptomatic against the background of gradual withdrawal of the drug.
- Brand name: Sinaflan®
- Active ingredient: Fluocinolone acetonide
- Dosage form: Ointment for external use.
- Manufacturer: Nizhpharm
- Country of Origin: Russia
Studies and clinical trials of Fluocinolone acetonide (Click to expand)
- Therapy of mycosis fungoides with topically applied fluocinolone acetonide under occlusive dressing
- Preparation of high specific activity tritium labeled 6α,9,-difluoro-11β,21-dihydroxy-16α,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-one, fluocinolone acetonide
- Effect of topical vehicle composition on the in vitro release of fluocinolone acetonide and its acetate ester
- An application of second-order UV-derivative spectrophotometry for study of solvolysis of a novel fluocinolone acetonide ester
- Base catalysed rearrangement of fluocinolone acetonide to a 17α-pregnane-21,16α-carbolactone
- Solid-state investigation of fluocinolone acetonide
- Clinical evaluation in treatment of oral lichen planus with topical fluocinolone acetonide: a 2-year follow-up
- Topical formulations of fluocinolone acetonide
- EFFECTS OF FLUOCINOLONE ACETONIDE CREAM ON THE SKIN WINDOW RECORD OF INFLAMMATORY EXUDATES.
- EFFECT OF FLUOCINOLONE ACETONIDE CREAM ON HUMAN SKIN BLOOD FLOW.
- FLUOCINOLONE ACETONIDE. A New Steroid Preparation for Topical Use.
- TREATMENT OF CHRONIC DISCOID LUPUS ERYTHEMATOSUS WITH FLUOCINOLONE ACETONIDE OINTMENT.
- THE EFFECT OF PAKTICLE SIZE AND VEHICLE ON THE PERCUTANEOUS ABSORPTION OF FLUOCINOLONE ACETONIDE.
- THE EFFECT OF FORMULATION ON THE CLINICAL RESPONSE TO TOPICAL FLUOCINOLONE ACETONIDE.
- PLASMA CORTISOL LEVELS AFTER TOPICAL USE OF FLUOCINOLONE ACETONIDE.
- A COMPARISON OF 0·1% BETAMETHASONE VALERATE AND 0·1% FLUOCINOLONE ACETONIDE IN THE TREATMENT OF PSORIASIS.
- FLUOCINOLONE ACETONIDE 0·2% CREAM—A CO-OPERATIVE CLINICAL TRIAL
- A dimethoxynaphthalene derivative (RS-43179 gel) compared with 0.025% fluocinolone acetonide gel in the treatment of psoriasis
- A randomized controlled trial of the efficacy and safety of a fixed triple combination (fluocinolone acetonide 0·01%, hydroquinone 4%, tretinoin 0·05%) compared with hydroquinone 4% cream in Asian patients with moderate to severe melasma
- TRAITEMENT OCCLUSIF DES DERMATITIS HERPÉTIFORMES, DES AFFECTIONS PEMPHIGÖIDES ET DU PEMPHIGUS VULGAIRE PAR L'ACETONIDE FLUOCINOLONE
- TOPICAL TREATMENT OF DERMATITIS HERPETIFORMIS WITH BETAMETHASONE-17-VALERATE AND FLUOCINOLONE ACETONIDE
- Fluocinolone Acetonide 0.01% in Peanut Oil: Safety and Efficacy Data in the Treatment of Childhood Atopic Dermatitis in Infants as Young as 3 Months of Age
- Contact sensitivity to betamethasone 17-valerate and fluocinolone acetonide
- Relative efficacy of fluocinolone acetonide compared with triamcinolone acetonide in treatment of oral lichen planus