Buy Fluomizin pills 10 mg 6 pcs
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Fluomizin® [Dequalinium chloride]

Medinova
1899 Items
2019-09-19
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$30.45
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Clinical Pharmacology

Pharmacotherapeutic group

Antiseptic.

ATX Code: G01AC05

Pharmacological properties

Pharmacodynamics.

Fluomizin® contains the active substance dequalinium chloride, which is a quaternary ammonium compound with a broad spectrum of antimicrobial activity. Dequalinium chloride is active against most Gram-positive bacteria Streptococcus spp., Including (beta-hemolytic streptococci of groups A and B), Staphylococcus aureus, Listeria spp .; anaerobes Peptostreptococcus (group D), fungi of the genus Candida (Candida tropicalis, Candida albicans, Candida glabrata), Gram-negative bacteria Gardnerella vaginalis, Escherichia coli, Serratia spp., Klebsiella spp., Pseudomonas spp., Proteus spp., Pseudomonas spp., Proteus spp., Klebsiella spp., Pseudomonas spp., Proteus spp., Pseudomonas spp., Proteus spp., Klebsiella spp., Pseudomonas spp., Proteus spp., Pseudomonas spp., Serratia spp. ).

Pharmacokinetics. With intravaginal administration, an extremely small amount of dequalinium chloride is absorbed through the mucous membrane of the vagina into the systemic circulation, is metabolized to the derivative of 2,2-dicarboxylic acid and excreted in an unconjugated form through the intestines.

Indications

• bacterial vaginosis

• candidal vaginitis

• trichomonas vaginitis

• reorganization of the vagina before gynecological operations and childbirth.

Composition

The composition of 1 tablet:

Active ingredient: dekaliniya chloride 10 mg

Excipients: lactose monohydrate, microcrystalline cellulose, magnesium stearate.

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Fluomizin® [Dequalinium chloride]

Dosage and Administration

The recommended dosing regimen is 1 vaginal tab. / Day. A vaginal tablet is inserted deep into the vagina in the evening before bedtime, lying on its back, with its legs slightly bent. During menstruation, treatment should be stopped and continue the previous course after its completion. It is necessary to conduct a full course of treatment (6 days) in order to avoid relapse.

Adverse reactions

Extremely rarely, local irritation (erosion) reactions, itching, burning or redness at the injection site can be observed. However, these adverse reactions may also be associated with symptoms of a vaginal infection.

Extremely rare fever, allergic reactions.

Contraindications

Hypersensitivity to the drug. Ulcerative lesions of the epithelium of the vagina and cervix.

The use of dequinium chloride before sexual activity is not recommended.

Drug interactions

Fluomizin® is incompatible with soap and other anionic surfactants.

Pregnancy and Lactation

The drug is approved for use throughout the period of pregnancy and lactation.

Special instructions

Fluomizin® contains excipients that sometimes do not completely dissolve in the vagina. Therefore, residues of the vaginal pills can be found in underwear. This does not affect the effectiveness of Fluomizin®.

In rare cases, with excessive vaginal dryness, it is likely that the pill will remain undissolved. To prevent this, before you enter the vaginal tablet, it must be moistened with water (for 1 second under a stream of water).

During the period of treatment it is recommended to change the pads and underwear more often. If the clinical signs of infection persist after completion of treatment, a microbiological examination should be repeated to identify the causative agent and confirm the diagnosis.

During the period of drug treatment is recommended to refrain from sex. To prevent urogenital reinfection, simultaneous treatment of sexual partners is necessary.

Overdosage

Data overdose available. When intravaginal use of overdose is unlikely.

  • Brand name: Fluomizin
  • Active ingredient: Dequalinium chloride
  • Dosage form: Vaginal pills.
  • Manufacturer: Medinova
  • Country of Origin: Switzerland

Studies and clinical trials of Dequalinium chloride (Click to expand)

  1. Toxicity of the mitochondrial poison dequalinium chloride in a murine model system
  2. Flow injection spectrofluorimetric study of the supramolecular interaction between β-cyclodextrin and dequalinium chloride and its analytical application
  3. Microvascular response to local application of dequalinium chloride : A VITAL MICROSCOPICAL STUDY OF HAMSTER'S CHEEK POUCH AND A MICROANGIOGRAPHIC STUDY OF RABBIT'S EAR
  4. Susceptibility testing ofAtopobium vaginaefor dequalinium chloride
  5. Failure to Enhance the in Vivo Killing of Human Ovarian Carcinoma by Sequential Treatment with Dequalinium Chloride and Tumor Necrosis Factor
  6. Determination for micro amounts of nucleic acids by a resonance light scattering technique with dequalinium chloride
  7. Dequalinium chloride: An active agent in ovarian cancer
  8. Enhanced in vivo killing of ovarian carcinoma by sequential treatment with dequalinium chloride and tumor necrosis factor
  9. Spectrophotometric determination of dequalinium chloride in pharmaceutical preparations
  10. Spectrophotometric Determination of Dequalinium Chloride
  11. A Comparison of Dequalinium Chloride Vaginal Tablets (Fluomizin®) and Clindamycin Vaginal Cream in the Treatment of Bacterial Vaginosis: A Single-Blind, Randomized Clinical Trial of Efficacy and Safety
  12. Inhibition of Rat Colon Tumor Isograft Growth With Dequalinium Chloride
  13. Local Treatment of Vaginal Infections of Varying Etiology with Dequalinium Chloride or Povidone Iodine
  14. Antimicrobial Activity of Dequalinium Chloride against Leading Germs of Vaginal Infections
  15. EFFECT OF RECOMBINANT HUMAN TUMOR-NECROSIS-FACTOR-ALPHA AND DEQUALINIUM CHLORIDE ON HUMAN OVARIAN-CANCER CELL-LINES IN-VITRO
  16. Use of locally delivered dequalinium chloride in the treatment of vaginal infections: a review
  17. Determination of Dequalinium Chloride and Related Impurities in Cosmetics And Pharmaceuticals by Reversed-Phase HPLC
  18. Development of Strength in Dequalinium Chloride-Treated Skin Incisions in Rat
  19. The Foretell Method of the Observation of Crystal Growth of Dequalinium Chloride in Short Time in Oil in Water Type Ointments
  20. Studies on Antifungal Substances. VII. : Studies on the Solubility of Various Dequalinium Salts. (1). Solubility of Dequalinium Salicylate, Chloride in Water-Propylene Glycol-Ethanol Systems
  21. Interaction of dequalinium chloride with phosphatidylcholine bilayers: a biophysical study with consequences on the development of lipid-based mitochondrial nanomedicines
  22. Effect of Dequalinium chloride troche in oral region

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