Fluomizin® [Dequalinium chloride]
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ATX Code: G01AC05
Fluomizin® contains the active substance dequalinium chloride, which is a quaternary ammonium compound with a broad spectrum of antimicrobial activity. Dequalinium chloride is active against most Gram-positive bacteria Streptococcus spp., Including (beta-hemolytic streptococci of groups A and B), Staphylococcus aureus, Listeria spp .; anaerobes Peptostreptococcus (group D), fungi of the genus Candida (Candida tropicalis, Candida albicans, Candida glabrata), Gram-negative bacteria Gardnerella vaginalis, Escherichia coli, Serratia spp., Klebsiella spp., Pseudomonas spp., Proteus spp., Pseudomonas spp., Proteus spp., Klebsiella spp., Pseudomonas spp., Proteus spp., Pseudomonas spp., Proteus spp., Klebsiella spp., Pseudomonas spp., Proteus spp., Pseudomonas spp., Serratia spp. ).
Pharmacokinetics. With intravaginal administration, an extremely small amount of dequalinium chloride is absorbed through the mucous membrane of the vagina into the systemic circulation, is metabolized to the derivative of 2,2-dicarboxylic acid and excreted in an unconjugated form through the intestines.
• bacterial vaginosis
• candidal vaginitis
• trichomonas vaginitis
• reorganization of the vagina before gynecological operations and childbirth.
The composition of 1 tablet:
Active ingredient: dekaliniya chloride 10 mg
Excipients: lactose monohydrate, microcrystalline cellulose, magnesium stearate.
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Dosage and Administration
The recommended dosing regimen is 1 vaginal tab. / Day. A vaginal tablet is inserted deep into the vagina in the evening before bedtime, lying on its back, with its legs slightly bent. During menstruation, treatment should be stopped and continue the previous course after its completion. It is necessary to conduct a full course of treatment (6 days) in order to avoid relapse.
Extremely rarely, local irritation (erosion) reactions, itching, burning or redness at the injection site can be observed. However, these adverse reactions may also be associated with symptoms of a vaginal infection.
Extremely rare fever, allergic reactions.
Hypersensitivity to the drug. Ulcerative lesions of the epithelium of the vagina and cervix.
The use of dequinium chloride before sexual activity is not recommended.
Fluomizin® is incompatible with soap and other anionic surfactants.
Pregnancy and Lactation
The drug is approved for use throughout the period of pregnancy and lactation.
Fluomizin® contains excipients that sometimes do not completely dissolve in the vagina. Therefore, residues of the vaginal pills can be found in underwear. This does not affect the effectiveness of Fluomizin®.
In rare cases, with excessive vaginal dryness, it is likely that the pill will remain undissolved. To prevent this, before you enter the vaginal tablet, it must be moistened with water (for 1 second under a stream of water).
During the period of treatment it is recommended to change the pads and underwear more often. If the clinical signs of infection persist after completion of treatment, a microbiological examination should be repeated to identify the causative agent and confirm the diagnosis.
During the period of drug treatment is recommended to refrain from sex. To prevent urogenital reinfection, simultaneous treatment of sexual partners is necessary.
Data overdose available. When intravaginal use of overdose is unlikely.
- Brand name: Fluomizin
- Active ingredient: Dequalinium chloride
- Dosage form: Vaginal pills.
- Manufacturer: Medinova
- Country of Origin: Switzerland
- Toxicity of the mitochondrial poison dequalinium chloride in a murine model system
- Flow injection spectrofluorimetric study of the supramolecular interaction between β-cyclodextrin and dequalinium chloride and its analytical application
- Microvascular response to local application of dequalinium chloride : A VITAL MICROSCOPICAL STUDY OF HAMSTER'S CHEEK POUCH AND A MICROANGIOGRAPHIC STUDY OF RABBIT'S EAR
- Susceptibility testing ofAtopobium vaginaefor dequalinium chloride
- Failure to Enhance the in Vivo Killing of Human Ovarian Carcinoma by Sequential Treatment with Dequalinium Chloride and Tumor Necrosis Factor
- Determination for micro amounts of nucleic acids by a resonance light scattering technique with dequalinium chloride
- Dequalinium chloride: An active agent in ovarian cancer
- Enhanced in vivo killing of ovarian carcinoma by sequential treatment with dequalinium chloride and tumor necrosis factor
- Spectrophotometric determination of dequalinium chloride in pharmaceutical preparations
- Spectrophotometric Determination of Dequalinium Chloride
- A Comparison of Dequalinium Chloride Vaginal Tablets (Fluomizin®) and Clindamycin Vaginal Cream in the Treatment of Bacterial Vaginosis: A Single-Blind, Randomized Clinical Trial of Efficacy and Safety
- Inhibition of Rat Colon Tumor Isograft Growth With Dequalinium Chloride
- Local Treatment of Vaginal Infections of Varying Etiology with Dequalinium Chloride or Povidone Iodine
- Antimicrobial Activity of Dequalinium Chloride against Leading Germs of Vaginal Infections
- EFFECT OF RECOMBINANT HUMAN TUMOR-NECROSIS-FACTOR-ALPHA AND DEQUALINIUM CHLORIDE ON HUMAN OVARIAN-CANCER CELL-LINES IN-VITRO
- Use of locally delivered dequalinium chloride in the treatment of vaginal infections: a review
- Determination of Dequalinium Chloride and Related Impurities in Cosmetics And Pharmaceuticals by Reversed-Phase HPLC
- Development of Strength in Dequalinium Chloride-Treated Skin Incisions in Rat
- The Foretell Method of the Observation of Crystal Growth of Dequalinium Chloride in Short Time in Oil in Water Type Ointments
- Studies on Antifungal Substances. VII. : Studies on the Solubility of Various Dequalinium Salts. (1). Solubility of Dequalinium Salicylate, Chloride in Water-Propylene Glycol-Ethanol Systems
- Interaction of dequalinium chloride with phosphatidylcholine bilayers: a biophysical study with consequences on the development of lipid-based mitochondrial nanomedicines
- Effect of Dequalinium chloride troche in oral region