GeloMyrtol® [Myrtol]
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Clinical Pharmacology
Gelomyrtol - mucolytic, antibacterial, anti-inflammatory.
Pharmacodynamics
It has a mucolytic, anti-inflammatory, antibacterial effect.
Pharmacokinetics
After ingestion is well absorbed in the small intestine. Cmax in blood plasma is achieved 1-3 hours after taking the drug. Approximately 60% of the drug and its metabolites are excreted in the urine, 5% - with feces, about 2% - lungs. It can cross the placental barrier; in the milk of lactating women.
Indications
Combined therapy of inflammatory diseases of the respiratory tract (acute and chronic bronchitis, sinusitis).
Composition
1 capsule contains:
Active substance: myrtol standardized 300 mg;
Excipients: medium chain triglycerides; gelatin; glycerol; sorbitol; hydrochloric acid 13%
Enteric coating: hypromellose acetate succinate; triethyl acetate; sodium lauryl sulfate; talc; dextrin; ammonium glycyrrhizinate.
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Dosage and Administration
Adults and children over 10 years
Adults: in acute inflammation, 1 capsule 3-4 times a day; in chronic inflammation - 1 capsule 2 times a day; to facilitate sputum discharge in the morning - an additional 1 capsule at bedtime.
Children from 10 to 18 years: in acute inflammation - 1 capsule 2 times a day; with chronic inflammation - 1 capsule per day.
The duration of treatment depends on the severity of the symptoms of the disease and is determined by the attending physician.
Adverse reactions
Allergic reactions (itching, skin rash, swelling of the face, bronchospasm), shortness of breath, tachycardia, dry mouth, stomach pain, flatulence, diarrhea, nausea, vomiting, increased mobility of kidney stones and gall bladder are possible.
With the development after taking the drug any other side effects, you should immediately consult a doctor.
Contraindications
- hypersensitivity to the drug;
- cholelithiasis;
- urolithiasis disease;
- bronchial asthma;
- I trimester of pregnancy;
- lactation period;
- children's age up to 10 years.
Pregnancy and Lactation
Due to the lack of special studies during pregnancy (II – III trimester), it should be used with caution as prescribed by a doctor, provided that the intended benefits to the mother outweigh the potential risk to the fetus.
Special instructions
Before you start using Gelomyrtol Forte, you should consult with your doctor.
Overdosage
Symptoms: in case of accidental overdose, nausea, vomiting, convulsions are possible, in severe cases - coma or respiratory failure. In rare cases, after severe intoxication, violations of the CAS are possible.
Treatment: the appointment of vaseline oil in a dose of 3 ml / kg; gastric lavage with 5% sodium bicarbonate solution (baking soda); oxygen ventilation.
- Brand name: GeloMyrtol®
- Active ingredient: Myrtol
- Dosage form: Capsules
- Manufacturer: Pohl Boskamp
- Country of Origin: Germany
Studies and clinical trials of Myrtol (Click to expand)
- Effect of Myrtol Standardized and Other Substances on the Respiratory Tract: Ciliary Beat Frequency and Mucociliary Clearance as Parameters
- Efficacy and Tolerability of Myrtol Standardized in Acute Bronchitis
- Efficacy and Tolerability of Myrtol Standardized in Long-term Treatment of Chronic Bronchitis
- Wirkung von Myrtol standardisiert* bei der Therapie der akuten Sinusitis - Ergebnisse einer doppelblinden, randomisierten Multicenterstudie gegen Plazebo
- The effect of myrtol standardized on human nasal ciliary beat frequency and mucociliary transport time
- Standardized myrtol attenuates lipopolysaccharide induced acute lung injury in mice
- Anti-inflammatory effects of myrtol standardized and other essential oils on alveolar macrophages from patients with chronic obstructive pulmonary disease
- Myrtol standardized affects mucociliary clearance
- Protective Effects of Myrtol Standardized Against Radiation-Induced Lung Injury
- MYRTOL AS A DISINFECTANT
- Myrtol improves post‑traumatic knee osteoarthritis by regulation of reactive oxygen species, transforming growth factor β1 and apoptosis in a mouse model
- Myrtol setzt Sekretolyse in Gang
- Frôhe Intervention mit Myrtol
- Is it appropriate regarding patient preference to take Myrtol standardized enteric-coated soft capsules after a meal rather than at fasted state? A food–drug pharmacokinetic interaction study in healthy Chinese volunteers