Genferon

Brand Biocad

In stock 838 Items

Available since: 2019-09-19

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Clinical Pharmacology

Genferon is a combined drug whose effect is due to its constituent components. It has a local and systemic effect.

Interferon alfa-2 has antiviral, antibacterial and immunomodulatory effects. Under the influence of interferon alpha-2 in the body, the activity of natural killer cells, T-helper cells, phagocytes, as well as the intensity of B-lymphocyte differentiation, increases. The activation of leukocytes contained in all layers of the mucous membrane ensures their active participation in the elimination of primary pathological foci and ensures the restoration of production of secretory immunoglobulin A.

Interferon alfa-2 also directly inhibits the replication and transcription of chlamydia viruses.

Taurine, which is part of the drug, has regenerating, reparative, membrane-and hepatoprotective, antioxidant, anti-inflammatory properties.

Benzocaine is a local anesthetic. Reduces the permeability of cell membranes for sodium ions, displaces calcium ions from receptors located on the inner surface of the membrane, blocks the conduction of nerve impulses. It prevents the appearance of pain impulses in the endings of the sensory nerves and their passage through the nerve fibers.

Indications

Genferon is used as part of the complex treatment of infectious and inflammatory diseases of the urogenital tract in children and women, including pregnant women: genital herpes, chlamydia, ureaplasmosis, mycoplasmosis, recurrent vaginal candidiasis, glandnerellez, trichomoniasis, papillomavirus infection, systolic infection, eye surgery, eye pattern, eye pattern, eye pattern, eye pattern, eye treatment, eye treatment, eye treatment, eye treatment, eye treatment, eye surgery, inflammatory disease of the urogenital tract , vulvovaginitis, Bartholinitis, adnexitis, prostatitis, urethritis, balanitis, balanoposthitis.

Composition

1 suppository contains: human recombinant alpha-2a interferon - 500,000 IU, taurine 0.01 g, and benzocaine 0.055 g;
Excipients: dextran 60,000, macrogol 1500, polysorbate 80, T2 emulsifier, sodium hydrocitrate, citric acid, purified water, solid fat.

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Dosage and Administration

Genferon candles can be used both vaginally and rectally. The route of administration, dosage and duration of the course depend on the age, specific clinical situation and are determined by the attending physician.

In adults and children over 7 years old, Genferon Light is used at a dosage of 250,000 IU of interferon alfa-2b per suppository. In children under 7 years old, it is safe to use the drug at a dosage of 125,000 IU of interferon alfa-2b per suppository.

In infectious and inflammatory diseases of the urogenital tract in women.
On 1 suppository (250000 IU or 500000 IU, depending on the severity of the disease) vaginally 2 times a day every day for 10 days. With prolonged forms 3 times a week every other day, 1 suppository for 1-3 months.

In case of a pronounced infectious-inflammatory process in the vagina, it is possible to use 1 candle 500,000 IU intravaginally in the morning and 1 candle 1,000,000 IU rectally overnight simultaneously with the introduction into the vagina of a candle containing antibacterial / fungicidal agents.

To normalize the indices of local immunity in the treatment of infectious and inflammatory diseases of the urogenital tract in women with a gestational age of 13–40 weeks, 1 suppository of 250,000 IU vaginally, 2 times daily for 10 days, is used.

In infectious and inflammatory diseases in men.
Rectal 1 suppository (500,000 IU or 1,000,000 IU, depending on the severity of the disease), 2 times a day for 10 days.

Adverse reactions

Allergic reactions: skin rash, itching. These phenomena are reversible and disappear after 72 hours after reducing the dose or discontinuing the drug.

With the introduction of the drug in a dose of 10 million IU / day increases the risk of the following side effects:
From the side of the central nervous system: headache.

From the hemopoietic system: leukopenia, thrombocytopenia.

Other: fever, excessive sweating, fatigue, myalgia, loss of appetite, arthralgia.

Contraindications

Hypersensitivity to the drug.

Drug interactions

When used together with antibiotics and other antimicrobial drugs used to treat urogenital infections, the effectiveness of Genferon increases.

When applied simultaneously with vitamins E and C, the effect of interferon is enhanced.

When combined with NSAIDs and anticholinesterase drugs potentiates the action of benzocaine.

When used together, the antibacterial activity of sulfonamides decreases (due to the action of benzocaine).

Pregnancy and Lactation

If necessary, the use of the drug in the II and III trimesters of pregnancy should relate the expected benefits to the mother and the potential risk to the fetus.