Glucosamine

Brand Medrick Limited

In stock 1324 Items

Available since: 2019-09-19

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Clinical Pharmacology

Clinico-pharmacological group: A drug that affects the metabolism in cartilage tissue. Stimulator of biosynthesis of proteoglycans

Pharmaco-therapeutic group: tissue regeneration stimulator

pharmachologic effect

Glucosamine helps to prevent the destruction of cartilage, stimulates the restoration of cartilage, has anti-inflammatory and analgesic effect, normalizes the production of intra-articular fluid. Improves mobility of joints, reduces the need for NSAIDs.

Pharmacokinetics

Suction and distribution

After ingestion quickly and completely absorbed in the digestive tract; prolonged form provides continuous release of the active substance and its uniform absorption; bioavailability of glucosamine after ingestion is 25-26% (exposed to the effect of "first passage" through the liver). After distribution in tissues, the highest concentrations are observed in the liver, kidneys and cartilage tissue.

Metabolism and excretion

Metabolized to water, carbon dioxide and urea. Excreted mainly by the kidneys.

Indications

- Osteoarthritis of the peripheral joints and spine.

Composition

1 tab.

Glucosamine hydrochloride 1500 mg

Excipients: calcium hydrophosphate - 62 mg, hypromellose (K200M) - 40 mg, povidone K90 - 40 mg, microcrystalline cellulose - 83 mg, hypromellose (K100M) - 80 mg, colloidal silicon dioxide - 5 mg, stearic acid - 40 mg

The composition of the shell: hypromellose E-5 - 20 mg, macrogol-6000 - 6 mg, opadry white (titanium dioxide, macrogol, hypromellose) - 11 mg.

Glucosamine is marketed under different brands and generic names, and comes in different dosage forms:

Brand name	Manufacturer	Country	Dosage form
Glucosamine	Medrick Limited	India	pills
Sustagard	Sotex	Russia	solution
Dona	Rottapharm	Italy	pills
Elbona	Ellara	Russia	ampoules
Dona	Rottapharm	Italy	ampoules
Dona	Rottapharm	Italy	sachet

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Dosage and Administration

The drug is taken orally. pills are swallowed whole with water.

The recommended dose is 1 tab. 1 time / day, for 6-12 weeks. On the recommendation of the doctor, the treatment is repeated at intervals of 2 months. A sustained therapeutic effect is achieved when taking the drug for 6 months.

Adverse reactions

The tolerability of the drug is good, in some cases possible: dysfunction of the gastrointestinal tract (epigastric pain, flatulence, constipation or diarrhea, nausea; allergic skin reactions (urticaria, pruritus).

Contraindications

- Severe renal dysfunction;

- pregnancy;

- lactation period;

- age up to 18 years (efficacy and safety have not been established);

- hypersensitivity to glucosamine and other components of the drug.

Precautions should be prescribed the drug for bronchial asthma, diabetes, intolerance to seafood (shrimp, clams).

Drug interactions

Increases the absorption of tetracyclines, reduces the effect of semi-synthetic penicillins, chloramphenicol.

The drug is compatible with paracetamol, NSAIDs and corticosteroids. When combined with NSAIDs, it enhances the anti-inflammatory and analgesic effects of the latter.

Pregnancy and Lactation

The drug is contraindicated in pregnancy and lactation.

Special instructions

The risk of allergic reactions increases with intolerance to seafood.

Influence on ability to drive motor transport and control mechanisms

There are no restrictions regarding the management of autotr

Overdosage

Cases of overdose are unknown.

Treatment: gastric lavage, symptomatic therapy.

Brand name: Glucosamine
Active ingredient: Glucosamine
Dosage form: pills of the modified release, film coated white or almost white color, oval.
Manufacturer: Medrick Limited
Country of Origin: India