Glutargin Alkoclean
Health
1443 Items
2019-09-19
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Clinical Pharmacology
Glutargin is a salt of arginine and glutamic acid. When alcohol intoxication stimulates the utilization of alcohol in the monooxygenase system of the liver, prevents the inhibition of the key enzyme ethanol utilization - alcohol dehydrogenase; accelerates inactivation and elimination of toxic products of ethanol metabolism as a result of an increase in the formation and oxidation of succinic acid; reduces the depressant effect of alcohol on the central nervous system due to the neurotransmitter properties of excitatory glutamic acid. Due to these properties, Glutargin exhibits antitoxic and sobering effects.
Glutargin also has hypoammonium and hepatoprotective properties due to the activation of the process of neutralization of ammonia in the body, antioxidant, antihypoxic and membrane stabilizing effects, positively affects the processes of energy supply in hepatocytes.
Glutargin does not have embryotoxic, gonadotoxic, mutagenic and teratogenic effects, does not cause allergic and immunotoxic reactions.
Indications
Prevention of intoxication and the hepatoxic effect of alcohol. Treatment of acute alcohol intoxication and moderate severity, as well as in the complex treatment of post intoxication disorders after acute severe alcohol poisoning.
Composition
Active ingredient: arginine glutamate (in terms of 100% substance) 1.0 g.
Auxiliary substance: microcrystalline cellulose (MCC 101) 0, 110 g, crospovidone 0.020 g, calcium stearate 0.010 g.
Glutargin Alkoclean is marketed under different brands and generic names, and comes in different dosage forms:
| Brand name | Manufacturer | Country | Dosage form |
|---|---|---|---|
| Glutargin Alkoclean | Zdorovye | Russia | pills |
| Glutargin Alkoclean | Zdorovye | Russia | tea bags |
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Dosage and Administration
The drug is prescribed for adults inside, regardless of the meal. For the prevention of intoxication and the hepatotoxic effect of alcohol, 2 pills (2g arginine glutamate) are prescribed 1-2 hours before taking alcohol or 1 tablet (1g arginine glutamate) 1 hour before taking alcohol and 1 tablet (1 g arginine glutamate) for 0 , 5 hours after taking alcohol.
Adverse reactions
Rarely, there may be feelings of mild discomfort in the epigastric region and nausea immediately after the use of the drug, which pass away on their own.
Contraindications
- hypersensitivity to the drug components
- children's age up to 18 years
- the period of pregnancy and breastfeeding
Carefully
- feverish condition
- increased excitability
- severe violations of filtration (nitric) kidney function (creatinine clearance 30 ml / min).
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