Glycerol
Nizhpharm
952 Items
2019-09-19
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Clinical Pharmacology
A laxative, softens and lubricates hardened fecal masses, facilitates their passage through the colon, irritates the intestinal mucosa, and reflexively stimulates intestinal motility.
Indications
Constipation (including during pregnancy and lactation). Prevention of constipation in patients who can not strain during defecation: painful thrombosed hemorrhoids, anal fissures or perianal abscess, anorectal stenosis, after myocardial infarction.
Composition
1 suppository contains: Active substances: glycerol (distilled glycerin) - 1.24 or 2.11 g in terms of 100% glycerol content (which corresponds to 1.32 g or 2.25 g to 94% glycerol with a density of 1.2481 g / cm3); Auxiliary substances: macrogol 400 (polyethylene oxide 400) - 0.12 g or 0.21 g, stearic acid - 0.12 g or 0.205 g, sodium carbonate decahydrate (10-water sodium carbonate) - 0.060 g or 0.103 g.
Glycerol is marketed under different brands and generic names, and comes in different dosage forms:
| Brand name | Manufacturer | Country | Dosage form |
|---|---|---|---|
| Glycerol | Nizhpharm | Russia | rectal suppositories |
| rectal suppositories | |||
| Glycerin Suppositories | rectal suppositories | ||
| Dexeril | cream | ||
| Glycerol | Samaramedprom | Russia | liquid |
| Glycelax | Moscow Pharmaceutical Factory | Russia | suppositories |
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Dosage and Administration
Rectal, 15-20 minutes after a meal. Suppositories 2.11 g: adults and children over 7 years old - 1 suppository 1 time per day. Suppositories 1.24 g: allowed to use from the first days of life. Children up to 3 years old - ½ suppository, children from 3 to 7 years old - 1 suppository 1 time per day. If necessary, increase the dose to 2 suppositories per day.
Adverse reactions
Allergic reactions, local reactions (itching and burning of the skin). With prolonged use - the weakening of the physiological process of defecation.
Contraindications
Hypersensitivity, hemorrhoids (acute phase), proctitis, paraproctitis, rectal tumors. Carefully Renal failure.
Pregnancy and Lactation
Perhaps the use of glycerin during pregnancy and lactation (breastfeeding) according to indications.
Special instructions
Systematic reception is not recommended. Treatment is stopped after the restoration of normal intestinal motility. Do not lubricate the suppositories with liquid or solid oils.
- Brand name: Glycerol
- Active ingredient: Glycerol
- Manufacturer: Nizhpharm
- Country of Origin: Russia
Studies and clinical trials of Glycerol (Click to expand)
- Efficacy and kinetics of glycerol inactivation of HIV-1 in split skin grafts
- Reduced pyruvate decarboxylase and increased glycerol-3-phosphate dehydrogenase [NAD+] levels enhance glycerol production in Saccharomyces cerevisiae
- Modulation of Glycerol and Ethanol Yields During Alcoholic Fermentation inSaccharomyces cerevisiae Strains Overexpressed or Disrupted forGPD1 Encoding Glycerol 3-Phosphate Dehydrogenase
- The importance of the glycerol 3-phosphate shuttle during aerobic growth ofSaccharomyces cerevisiae
- Anaerobic and aerobic batch cultivations ofSaccharomyces cerevisiae mutants impaired in glycerol synthesis
- Crystal structure of Escherichia coli uracil DNA glycosylase and its complexes with uracil and glycerol: Structure and glycosylase mechanism revisited
- Interactions of Glycerol with Water in the Gaseous State under Field Ionization Conditions
- K4[Fe(CN)6]/Glycerol—A New Liquid Matrix System for Matrix-assisted Laser Desorption/Ionization Mass Spectrometry of Hydrophobic Compounds
- Fast-atom Bombardment Mass Spectrometry of Mono- and Difluorophosphonate Analogues of Glycerol-3-phosphate
- A Study of Formation and Fragmentation of Ionic Complexes of α-Amino Acids and Peptides with Al(III)–Glycerol by Fast Atom Bombardment Mass Spectrometry
- Kinetic, dynamic, and pathway studies of glycerol metabolism by Klebsiella pneumoniae in anaerobic continuous culture: I. The phenomena and characterization of oscillation and hysteresis
- Kinetic, dynamic, and pathway studies of glycerol metabolism by Klebsiella pneumoniae in anaerobic continuous culture: II. Analysis of metabolic rates and pathways under oscillation and steady-state conditions
- An indirect optimization method for biochemical systems: Description of method and application to the maximization of the rate of ethanol, glycerol, and carbohydrate production in Saccharomyces cerevisiae
- Effects of glucose and glycerol on γ-poly(glutamic acid) formation by Bacillus licheniformis ATCC 9945a
- Thermobarostability of α-chymotrypsin in reversed micelles of aerosol OT in octane solvated by water-glycerol mixtures
- Uncoupled glycerol distribution as the origin of the accumulation of 3-hydroxypropionaldehyde during the fermentation of glycerol by Enterobacter agglomerans CNCM 1210
- Kinetic, dynamic, and pathway studies of glycerol metabolism by Klebsiella pneumoniae in anaerobic continuous culture: III. Enzymes and fluxes of glycerol dissimilation and 1,3-propanediol formation
- Kinetic, dynamic, and pathway studies of glycerol metabolism by Klebsiella pneumoniae in anaerobic continuous culture: IV. Enzymes and fluxes of pyruvate metabolism
- Continuous enzymatic esterification of glycerol with (poly)unsaturated fatty acids in a packed-bed reactor
- Glial- and fat-specific expression of the rat glycerol phosphate dehydrogenase-luciferase fusion gene in transgenic mice
- Oligodendrocytes as glucocorticoids target cells: functional analysis of the glycerol phosphate dehydrogenase gene
- ESR parameters and dynamic behavior of β-phosphorylated nitroxide radicals in glycerol solution
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