Buy Gynalgin pills 10 pcs
  • Buy Gynalgin pills 10 pcs

Gynalgin® [Metronidazole, chlorquinaldol]

AiCn Polfa Rzeszow
1666 Items
2019-09-19
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Clinical Pharmacology

Trichomonacid, antiprotozoal, antifungal, bactericidal, antibacterial.

Combined preparation for intravaginal use.

Metronidazole refers to nitro-5-imidazoles. The mechanism of action of metronidazole is the biochemical reduction of the 5-nitro group of metronidazole by intracellular transport proteins of anaerobic microorganisms and protozoa. The recovered 5-nitro group of metronidazole interacts with the microbial cell DNA, inhibiting the synthesis of their nucleic acids, which leads to the death of microorganisms.

Metronidazole is an effective antimicrobial and antiprotozoal agent of a wide spectrum of action. The drug exhibits high activity against Trichomonas vaginalis, Giardia intestinalis, Entamoeba histolytica, Lamblia intestinalis, as well as against obligate anaerobes (spore-and non-sporiferous) - Bacteroides spp. (B. fragilis, B. ovatus, B. distasonis, B. thetaiotaomicron, B. vulgatus), Fusobacterium spp., Clostridium spp., Peptostreptococcus spp., Sensitive Eubacterium strains.

Aerobic microorganisms and facultative anaerobes are not sensitive to metronidazole.

Chlorquinaldol acts on the following strains of pathogenic bacteria: Corynebacterium diphtheriae, Streptococcus pyogenes, Staphylococcus aureus, Pseudomonas aeruginosa, Proteus vulgaris, Salmonella, Shigella, Escherichia coli.

It also exhibits activity with respect to the simplest: Entamoeba histolytica, Lamblia intestinalis, Trichomonas vaginalis and some fungi.

Citric acid lowers the pH of the vagina, promotes the growth and reproduction of Doderlein sticks.

Pharmacokinetics

With intravaginal use, metronidazole undergoes systemic absorption. Cmax in blood after intravaginal administration is approximately 50% of Cmaxwhich is achieved after a single dose of an equivalent dose of metronidazole inside.

Metronidazole is almost completely metabolized in the liver to form inactive derivatives.

T1/2 - 8 h. Metronidazole is excreted mainly with urine.

With intravaginal application, chlorquinaldol is slightly absorbed. Trihomonacid, antiprotozoal, antifungal, bactericidal, antibacterial.

Combined preparation for intravaginal use.

Metronidazole refers to nitro-5-imidazoles. The mechanism of action of metronidazole is the biochemical reduction of the 5-nitro group of metronidazole by intracellular transport proteins of anaerobic microorganisms and protozoa. The recovered 5-nitro group of metronidazole interacts with the microbial cell DNA, inhibiting the synthesis of their nucleic acids, which leads to the death of microorganisms.

Metronidazole is an effective antimicrobial and antiprotozoal agent of a wide spectrum of action. The drug exhibits high activity against Trichomonas vaginalis, Giardia intestinalis, Entamoeba histolytica, Lamblia intestinalis, as well as against obligate anaerobes (spore-and non-sporiferous) - Bacteroides spp. (B. fragilis, B. ovatus, B. distasonis, B. thetaiotaomicron, B. vulgatus), Fusobacterium spp., Clostridium spp., Peptostreptococcus spp., Sensitive Eubacterium strains.

Aerobic microorganisms and facultative anaerobes are not sensitive to metronidazole.

Chlorquinaldol acts on the following strains of pathogenic bacteria: Corynebacterium diphtheriae, Streptococcus pyogenes, Staphylococcus aureus, Pseudomonas aeruginosa, Proteus vulgaris, Salmonella, Shigella, Escherichia coli.

It also exhibits activity with respect to the simplest: Entamoeba histolytica, Lamblia intestinalis, Trichomonas vaginalis and some fungi.

Citric acid lowers the pH of the vagina, promotes the growth and reproduction of Doderlein sticks.

Pharmacokinetics

With intravaginal use, metronidazole undergoes systemic absorption. Cmax in blood after intravaginal administration is approximately 50% of Cmaxwhich is achieved after a single dose of an equivalent dose of metronidazole inside.

Metronidazole is almost completely metabolized in the liver to form inactive derivatives.

T1/2 - 8 h. Metronidazole is excreted mainly with urine.

With intravaginal use, chlorquinaldol is slightly absorbed.

Indications

Infectious and inflammatory diseases of the vagina caused by pathogens that are sensitive to the drug.

Composition

Vaginal pills 1 tab.
metronidazole 250 mg
chlorochinaldol 100 mg
excipients: anhydrous citric acid, lactose monohydrate; rice starch; sodium starch glycolate (ultraamylopectin); polyethylene glycol 6000 (carbowax 6000); magnesium stearate  

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Gynalgin® [Metronidazole, chlorquinaldol]

Dosage and Administration

Gynacoheel is recommended to appoint three times a day, 10 drops. Drops must be dissolved in 100 ml of water. The duration of treatment is 14-21 days.
In the acute course of the disease or exacerbations of chronic processes, you can take the drug every 15 minutes, 10 drops for two hours.

The drug Gynacoheel is contraindicated for persons who have an increased sensitivity to substances that are part of the drug (including a history).
The use of Gynacoheel®ya patients with diseases of the thyroid gland is possible only after consulting a doctor.

Special instructions

When using the homeopathic drug Gynacoheel, in some cases a primary worsening can be observed - a temporary worsening of the existing symptoms. It is necessary in this case, immediately consult a doctor.

Overdosage

Overdose cases have not yet been reported.

  • Brand name: Gynacoheel®
  • Active ingredient: Homeopathic composition
  • Dosage form: Drops for oral administration homeopathic in the form of a clear liquid from slightly pale yellow to light yellow in color, with the smell of ethanol.
  • Manufacturer: Heel
  • Country of Origin: Germany

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