Gynofort® [Butoconazole]

Brand Gedeon Richter

In stock 1556 Items

Available since: 2019-09-19

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Clinical Pharmacology

Gynofort - antifungal.

Pharmacodynamics

Butoconazole, an imidazole derivative, has fungicidal activity against fungiCandida, Trichophyton, Microsporum, Epidermophyton and some gram-positive bacteria. Most effective for candida. By blocking the formation of ergosterol from lanosterol in the cell membrane, increases the permeability of the membrane, which leads to the lysis of the fungal cell.

Vaginal cream is a water-in-oil emulsion, therefore, the wearer of butoconazole has a bioadhesive property (bioadhesive gives an increase in bioavailability and duration of action of the drug). With intravaginal use, butoconazole is located on the vaginal mucosa for 4–5 days.

Pharmacokinetics

The cream has a high bioadhesive properties. With intravaginal administration, about 1.7% of the administered dose is absorbed. C_max in blood it is 2–18.6 ng / ml and is reached in 13 hours. Butoconazole is extensively metabolized and partially excreted through the intestines and kidneys.

Indications

Candida albicans vaginal candidiasis.

Composition

1 g of cream contains:

Active substance: butoconazole nitrate 20 mg;

Excipients: sorbitol - 399.78 mg; mineral oil - 80.32 mg; glyceryl monostearate - 27.13 mg; polyglyceryl-3-oleate - 27.13 mg; wax - 4.52 mg; colloidal silicon dioxide - 10.13 mg; disodium edetate - 0.5 mg; methyl parahydroxybenzoate - 1.8 mg; propyl parahydroxybenzoate - 0.5 mg; propylene glycol - 50 mg; water - 378.19 mg

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Dosage and Administration

Gynofort used intravaginally. The treatment consists of a single application of the contents of one applicator (about 5 g), inserted into the vagina at any time of the day. In the case of persisting symptoms of the disease, repeat the microbiological study.

Adverse reactions

Burning, itching, soreness and swelling of the vaginal wall, pain / cramps in the lower abdomen.

Contraindications

hypersensitivity to any of the components of the drug;
gestation period;
lactation;
children's age up to 18 years (efficiency and safety are not established).

Drug interactions

Cream Gynofort^® contains mineral oil, damaging products from latex or rubber (including condoms or intravaginal diaphragms), therefore within 72 hours after using Gynofort^® It is not recommended to use the above contraceptives. Other contraceptive methods should be used.

Special instructions

If the clinical signs of infection persist after completion of treatment, a microbiological examination should be repeated to identify the causative agent and confirm the diagnosis.