Hydrocortisone
Nizhpharm
1350 Items
2019-09-19
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Clinical Pharmacology
The combined drug, inhibits the development of inflammatory skin reactions, especially of allergic origin, complicated by bacterial infection, as a result of the total action of the components that make up the drug. Oxytetracycline is an antibiotic from the tetracycline group, has a bacteriostatic effect. Active against Gram-positive and Gram-negative bacteria, Rickettsia spp., Treponema spp., Chlamydia spp., Mycoplasma spp. Hydrocortisone - glucocorticosteroid, has anti-inflammatory, anti-allergic, anti-exudative and antipruritic effects. Inhibits phagocytosis; reduces the synthesis of prostaglandins and leukotrienes by inhibiting the activity of phospholipase A2 and reducing the release of arachidonic acid from the phospholipids of cell membranes. Inhibits the release of interleukins and other cytokines that cause the inflammatory process; inhibits the release of histamine and the occurrence of local allergic reactions. Reduces the synthesis of proteins and the deposition of collagen in the skin, prevents the development of connective tissue, weakens proliferative processes.
Indications
Newborn dermatitis (cystic and exfoliative), infected diaper rash, folliculitis, furunculosis, carbuncle, impetigo, erysipelas; infected eczema and wounds, erosion; urticaria of the newborn; simple and allergic dermatitis, seborrhea; "Sunny" erythematous rashes; erythema multiforme exudative; insect bites; allergic and suppurative diseases of the external auditory canal; varicose ulcers of the leg, burns, frostbite.
Composition
Composition per 1 g:
Active ingredient: hydrocortisone acetate - 10.0 mg; excipients: petrolatum, lanolin, pentaerythritol dioleate (pentol), stearic acid 95, methyl parahydroxybenzoate, propyl parahydroxybenzoate, purified water.
Hydrocortisone is marketed under different brands and generic names, and comes in different dosage forms:
| Brand name | Manufacturer | Country | Dosage form |
|---|---|---|---|
| Hydrocortisone | Nizhpharm | Russia | ointment |
| Pimafucort | Astellas | Netherlands | ointment |
| Locoid Crelo | Astellas | Netherlands | emulsion |
| Locoid | Astellas | Netherlands | ointment |
| Locoid | Astellas | Netherlands | cream |
| Hydrocortisone | Synthesis | Russia | ointment |
| Posterisan forte | Dr kade | Germany | rectal suppositories |
| Posterisan forte | Dr kade | Germany | ointment |
| Posterized | Dr kade | Germany | rectal suppositories |
| Hydrocortisone | Tatkhimpharmpreparaty | Russia | ointment |
| Lokoid Lipokrem | Astellas | Netherlands | cream |
| Laticort | Elfa Pharmaceutical Plant | Poland | ointment |
| Cortef | Pfizer | USA | pills |
| Hydrocortisone pos | Ursapharm Artsnaymittel | Germany | ointment |
| Solu Cortef | Pfizer | USA | lyophilisate |
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Dosage and Administration
Locally, externally.
Ointment in the amount of 0.5-1 g is applied with a thin layer to the affected skin 1-3 times a day or under a sterile gauze bandage.
The duration of treatment is individual.
Adverse reactions
Rarely possible - allergic reactions, skin irritation, itching, rash. With prolonged use and / or application to large surfaces - systemic side effects of glucocorticosteroids. When applied to the skin of the face - possible telangiectasia, atrophy of the subcutaneous tissue in the mouth.
Contraindications
Hypersensitivity, skin tuberculosis, skin tumors, precancerous conditions, mycosis, viral skin diseases (herpes, chicken pox); pregnancy, lactation (when applied to extensive lesions).
Drug interactions
Cases of interaction or incompatibility with other drugs are not described.
Special instructions
During treatment with glucocorticosteroids (GCS), smallpox vaccination should not be given and other types of immunization should be planned (due to the immunosuppressive effect of GCS).
Overdosage
Cases of overdosing Hyoxizone ointment have been reported.
- Active ingredient: Hydrocortisone
Studies and clinical trials of Hydrocortisone (Click to expand)
- Flutamide withdrawal plus hydrocortisone resulted in clinical complete response in a patient with prostate carcinoma
- Selective effects of hydrocortisone on intestinal lipoprotein and apolipoprotein synthesis in the human fetus
- Retinoic acid inhibits hydrocortisone-stimulated expression of phenol sulfotransferase in bovine bronchial epithelial cells
- Separation of hydrocortisone and epi-hydrocortisone by solvent extraction
- Bioconversion of hydrocortisone to prednisolone by immobilized bacterial cells in a two-liquid-phase system
- Antitumor activity of suramin in hormone-refractory prostate cancer controlling for hydrocortisone treatment and flutamide withdrawal as potentially confounding variables
- Fixed higher dose schedule of suramin plus hydrocortisone in patients with hormone refractory prostate carcinoma : A multicenter Phase II study
- Effects of hydrocortisone on the formation of gap junctions and the abnormal growth of cilia within the rat anterior pituitary gland: Possible role of gap junctions on the regulation of cell development
- Alterations in shock-induced fighting and locomotor activity following intracerebroventricular injection of hydrocortisone in the rat
- Disposition of intra-articularly injected cortisone and hydrocortisone
- Hypophysis-adrenal system in the fetal rat. Effects of hydrocortisone, cortisone, DCA, adrenalectomy and maternal hypophysectomy upon the hypophysis
- The effect of hydrocortisone on extracellular connective tissue fibrils in the early chick embryo
- Light and electron microscopic observations on hydrocortisone-induced cleft palate in hamsters
- Qualitative and quantitative morphologic study of peyer's patches of the mouse after neonatal thymectomy and hydrocortisone injection
- Morphological development of the epithelium of the embryonic chick intestine in culture: Influence of thyroxine and hydrocortisone
- Mechanisms of increased brain glucose and glycogen after hydrocortisone: Possible clinical significance
- Effect of blending methyl β-cyclodextrin on the release of hydrophobic hydrocortisone into water from polyurethane
- Some effects of exogenous hydrocortisone on pregnancy in the rat
- Similarity of congenital malformations produced by hydrocortisone to those produced by adrenalectomy in guinea pigs
- The differential effect of hydrocortisone on the short-lived small lymphocyte
- Role of chondrocytes and hydrocortisone in resorption of proximal fragment of Meckel's cartilage: An in vitro and in vivo study
- Resistance to therapy in mature palmerston north mice treated with cyclophosphamide or hydrocortisone sodium succinate
- Effect of cyclophosphamide, hydrocortisone, and levamisole on collagen-induced arthritis in rats
- The effects of in vivo hydrocortisone on lymphocyte-mediated cytotoxicity
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