Buy Hydrocortisone bottle 25mg + 5mg/ml bottle 5 ml 1 pc.
  • Buy Hydrocortisone bottle 25mg + 5mg/ml bottle 5 ml 1 pc.

Hydrocortisone, Lidocaine

Gedeon Richter
841 Items
2019-09-19
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$24.06
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Clinical Pharmacology

Hydrocortisone has anti-inflammatory, desensitizing (preventing or inhibiting allergic reactions) and antiallergic effect, has immunosuppressive (suppressive body defenses) activity.

GKS. Suppresses the function of leukocytes and tissue macrophages. Limits the migration of leukocytes to the area of ​​inflammation. Violates the ability of macrophages to phagocytosis, as well as the formation of interleukin-1. Promotes stabilization of lysosomal membranes, thereby reducing the concentration of proteolytic enzymes in the area of ​​inflammation. Reduces capillary permeability due to histamine release. Suppresses the activity of fibroblasts and the formation of collagen.

Inhibits the activity of phospholipase A2, which leads to the suppression of the synthesis of prostaglandins and leukotrienes. Suppresses the release of COX (mainly COX-2), which also helps to reduce the production of prostaglandins.

Reduces the number of circulating lymphocytes (T-and B-cells), monocytes, eosinophils and basophils due to their movement from the vascular bed to the lymphoid tissue; inhibits the formation of antibodies.

Hydrocortisone inhibits the release of ACTH and β-lipotropin by the pituitary gland, but does not reduce the level of circulating β-endorphin. Inhibits the secretion of TSH and FSH.

With the direct application of the vessels has a vasoconstrictor effect.

Hydrocortisone has a pronounced dose-dependent effect on the metabolism of carbohydrates, proteins and fats. Stimulates gluconeogenesis, promotes the uptake of amino acids by the liver and kidneys and increases the activity of gluconeogenesis enzymes. In the liver, hydrocortisone enhances the deposition of glycogen, stimulating the activity of glycogen synthetase and the synthesis of glucose from the products of protein metabolism. Increasing blood glucose activates insulin secretion.

Hydrocortisone inhibits glucose uptake by fat cells, which leads to activation of lipolysis. However, due to an increase in insulin secretion, lipogenesis is stimulated, which leads to fat accumulation.

It has a catabolic effect in the lymphoid and connective tissue, muscles, adipose tissue, skin, bone tissue. To a lesser extent than mineralocorticoids, it affects the processes of water-electrolyte metabolism: it promotes the excretion of potassium and calcium ions, and the delay in the body of sodium and water ions. Osteoporosis and Itsenko-Cushing syndrome are the main factors limiting long-term therapy of SCS. As a result of the catabolic effect, growth can be suppressed in children.

In high doses, hydrocortisone can increase the excitability of brain tissue and contributes to lowering the threshold of convulsive readiness. Stimulates excessive production of hydrochloric acid and pepsin in the stomach, which contributes to the development of peptic ulcers.

With systemic use, the therapeutic activity of hydrocortisone is due to the anti-inflammatory, anti-allergic, immunosuppressive and anti-proliferative effects.

When applied topically and locally, the therapeutic activity of hydrocortisone is due to the anti-inflammatory, antiallergic and anti-exudative (due to the vasoconstrictor effect) action.

In anti-inflammatory activity 4 times weaker than prednisone, in mineralocorticoid activity superior to other GCS.

Binding to plasma proteins - 40-90%. Metabolized mainly in the liver. T1/2 - 80-120 min. Excreted by the kidneys mainly in the form of metabolites.

Indications

Allergic skin diseases, inflammatory diseases of the joints, rheumatism, arthritis, bursitis, bronchial asthma, acute adrenal insufficiency, thyroiditis, thyrotoxic crisis.

Composition

1 ml of suspension contains:

Active substance: hydrocortisone acetate 25 mg;

Excipients: propylene glycol - 0.2 ml; sorbitol - 20 mg; Povidone - 10 mg; sodium chloride - 1.4 mg; benzyl alcohol - 0,015 ml; water for injection - up to 1 ml.

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Hydrocortisone, Lidocaine

Dosage and Administration

Intramuscularly (deeply) into the gluteus muscle in a dose of 50–300 mg to 1000–1500 mg / day. Before use, the contents of the vials should be shaken until a homogeneous suspension is formed.

In acute, life-threatening conditions, 100–150 mg is administered every 4 hours for 48 hours; then every 8–12 hours. For children, every 4 hours, 1–2 mg / kg, the optimal daily dose is 6–9 mg / kg.

In the cavity of the joints administered 5–25 mg (0.1–1 ml (depending on the size of the joint) 1 time per week. 3-5 injections per course. The effect of the drug begins 6–25 hours after the injection and lasts several days or weeks.

Adverse reactions

Virilization, obesity, hirsutism, menstrual disorders, osteoporosis, mental disorders, Itsenko-Cushing's symptom complex.

Contraindications

Severe diabetes mellitus, hypertension, circulatory failure III degree, Cushing's disease, psychoses, nephritis, osteoporosis, gastric ulcer and duodenal ulcer, syphilis, active tuberculosis.

Drug interactions

The effect is weakened by barbiturates, diuretics enhance hypokalemia. Reduces the effect of hypoglycemic agents.

Pregnancy and Lactation

Studies on the safety and efficacy of hydrocortisone in pregnant women and nursing were not conducted. There is no accurate data on glucocorticoid permeation into breast milk when applied topically. However, risk cannot be excluded completely. The use of hydrocortisone in pregnant women and nursing is allowed only by prescription by the attending physician, when the expected therapeutic effect for the mother outweighs the potential risk to the fetus and child.

Special instructions

With tuberculosis can only be used in conjunction with tuberculostatic agents.

In patients with diabetes mellitus, they are used only if there are absolute indications or to prevent probable insulin resistance. In infectious diseases can be applied with caution and only in conjunction with specific antibiotic therapy. With prolonged use, it is necessary to prescribe potassium preparations to prevent possible hypokalemia. During treatment, it is advisable to regularly measure blood pressure, urinalysis and fecal occult blood test. To complete the treatment should be gradually reducing the dose of the drug and deciding whether to use ACTH (skin test).

During treatment with hydrocortisone, it is advisable to re-determine the dose of oral antidiabetic agents and anticoagulants.

When used in combination with diuretics, it is necessary to control the electrolyte metabolism in the body. In the case of combined use with salicylates while reducing the dose of corticosteroids, it is necessary to simultaneously reduce the dose of salicylate. If a history of psychosis is indicated, the drug should be used with caution.

Before use, the contents of the bottle should be carefully shaken.

Overdosage

Excess doses or prolonged administration of the drug can lead to inhibition of glucocorticoid production, increased blood pressure, ulcerative bleeding of the gastrointestinal tract, exacerbation of chronic infections, the development of Itsenko-Cushing snide.

Treatment: symptomatic.

  • Active ingredient: Hydrocortisone, Lidocaine

Studies and clinical trials of Hydrocortisone, Lidocaine (Click to expand)

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