Ibuprofen

Ibuprofen takes orally after eating.
For rheumatoid arthritis appoint 800 mg 3 times a day.
In osteoarthritis and ankylosing spondylitis Ibuprofen is used in 400-600 mg 3-4 times a day.
In juvenile rheumatoid arthritis the drug is used in a dose of 30-40 mg / kg of body weight per day.
In case of soft tissue injuries, sprains the drug is prescribed 600 mg 2-3 times a day.
When pain syndrome of moderate intensity the drug is prescribed 400 mg 3 times a day. The maximum daily dose of 2.4 g
Children over 12 years old the initial dose is 150-300 mg 3 times a day, the maximum dose is 1 g, then 100 mg 3 times a day; in juvenile rheumatoid arthritis - 30-40 mg / kg / day in divided doses.
To reduce body temperature 39.2 ° C and above - 10 mg / kg / day, below 39.2 ° С - 5 mg / kg / day.

Contraindications

Hypersensitivity, gastric ulcer or duodenal ulcer (in acute stage), ulcerative colitis, diseases of the optic nerve, scotoma, amblyopia, impaired color vision, liver cirrhosis with portal hypertension, "aspirinovaya" asthma (triggered by ASK or other NSAIDs) heart insufficiency, edema, arterial hypertension, hemophilia, hypocoagulation, leukopenia, hemorrhagic diathesis, hearing loss, vestibular pathology, deficiency of glucose-6-phosphate dehydrogenase; pregnancy (III trimester).
With care - hyperbilirubinemia, pregnancy, lactation; gastric ulcer and duodenal ulcer (in history), gastritis, enteritis, colitis; liver and / or renal failure, blood diseases of unknown etiology, children age (up to 12 years).

In animal studies, no adverse effect of Ibuprofen on the fetus was found. Due to the lack of a sufficient number of well-controlled observations in humans, the drug should be used in the first and second trimesters of pregnancy only in cases of urgent need. Ibuprofen inhibits uterine muscle contraction. The effect of Ibuprofen on the fetus can cause premature closure of the botanal duct, which can lead to the development of pulmonary hypertension in the newborn. Ibuprofen should not be used at the end (third trimester) of pregnancy. No ibuprofen excretion was detected with mother's milk. However, due to the limited scope of these studies and the possible adverse effect of inhibition of prostaglandin synthesis in the newborn, it is not recommended to use the drug during the breastfeeding period. With long-term use of Ibuprofen, periodic monitoring of the pattern of peripheral blood and the functional state of the liver and kidneys is recommended. At the onset of symptoms of gastropathy, careful monitoring is shown, including esophagogastroduodenoscopy, blood analysis with hemoglobin, hematocrit, fecal occult blood analysis. To prevent the development of NSAID-gastropathy, it is recommended to combine Ibuprofen with PG E (misoprostol) preparations.

With caution, the drug is prescribed to patients with impaired liver, kidney, cardiovascular diseases, with a history of gastric ulcer and / or duodenal ulcer, bleeding from the gastrointestinal tract.
Compared with other NSAIDs, Ibuprofen has the least ulcerogenic effect on the gastrointestinal mucosa.
With prolonged use of the drug, it is necessary to monitor the function of the liver and / or kidneys, the picture of peripheral blood.

In the case of overdose, which is manifested in increased signs of side effects, you should stop treatment and consult a doctor.