Ibuprofen is a non-steroidal anti-inflammatory drug that is used to relive pain, fever, and inflammation caused by various conditions. It is also often used in combination with the other drugs, such as paracetamol
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Ibuprofen is a non-steroidal anti-inflammatory drug, a derivative of phenylpropionic acid. It has anti-inflammatory, analgesic and antipyretic effects. The effect of the drug is due to inhibition of prostaglandin synthesis by blocking the enzyme cyclooxygenase.
Suppresses platelet aggregation. With prolonged use has a desensitizing effect.
Rheumatoid arthritis, osteoarthritis, articular syndrome with exacerbation of gout, psoriatic arthritis, ankylosing spondylitis (ankylosing spondyloarthritis), cervical spondylosis, Barre-Lieu syndrome (cervical migraine, vertebral artery syndrome); neuralgia, myalgia, tendonitis, bursitis, tendovaginitis, neuralgic amyotrophy, stretching of the ligament apparatus, hematoma, sciatica, traumatic inflammation of the soft tissues and the musculoskeletal system; feverish states of various genesis (including after immunization); symptomatic treatment of influenza and ARVI; postural hypotension while taking antihypertensive drugs; nephrotic syndrome (to reduce the severity of proteinuria). As an aid: infectious and inflammatory diseases of upper respiratory tract (tonsillitis, pharyngitis, laryngitis, sinusitis, rhinitis), bronchitis, pneumonia, inflammatory processes in the pelvis, adnexitis, primary dysmenorrhea, algomenorrhea, postoperative pain, headache and toothache, panniculitis.
1 tablet contains ibuprofen 200 mg
Ibuprofen is marketed under different brands and generic names, and comes in different dosage forms:
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|Nurofen for children||Reckitt Benckiser||UK||suspension|
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Dosage and Administration
Ibuprofen takes orally after eating.
For rheumatoid arthritis appoint 800 mg 3 times a day.
In osteoarthritis and ankylosing spondylitis Ibuprofen is used in 400-600 mg 3-4 times a day.
In juvenile rheumatoid arthritis the drug is used in a dose of 30-40 mg / kg of body weight per day.
In case of soft tissue injuries, sprains the drug is prescribed 600 mg 2-3 times a day.
When pain syndrome of moderate intensity the drug is prescribed 400 mg 3 times a day. The maximum daily dose of 2.4 g
Children over 12 years old the initial dose is 150-300 mg 3 times a day, the maximum dose is 1 g, then 100 mg 3 times a day; in juvenile rheumatoid arthritis - 30-40 mg / kg / day in divided doses.
To reduce body temperature 39.2 ° C and above - 10 mg / kg / day, below 39.2 ° С - 5 mg / kg / day.
Hypersensitivity, gastric ulcer or duodenal ulcer (in acute stage), ulcerative colitis, diseases of the optic nerve, scotoma, amblyopia, impaired color vision, liver cirrhosis with portal hypertension, "aspirinovaya" asthma (triggered by ASK or other NSAIDs) heart insufficiency, edema, arterial hypertension, hemophilia, hypocoagulation, leukopenia, hemorrhagic diathesis, hearing loss, vestibular pathology, deficiency of glucose-6-phosphate dehydrogenase; pregnancy (III trimester).
With care - hyperbilirubinemia, pregnancy, lactation; gastric ulcer and duodenal ulcer (in history), gastritis, enteritis, colitis; liver and / or renal failure, blood diseases of unknown etiology, children age (up to 12 years).
With the simultaneous appointment of ibuprofen may cause a decrease in the diuretic effect of furosemide.
When combined, Ibuprofen enhances the effect of difenin, coumarin anticoagulants, oral hypoglycemic drugs.
Pregnancy and Lactation
In animal studies, no adverse effect of Ibuprofen on the fetus was found. Due to the lack of a sufficient number of well-controlled observations in humans, the drug should be used in the first and second trimesters of pregnancy only in cases of urgent need. Ibuprofen inhibits uterine muscle contraction. The effect of Ibuprofen on the fetus can cause premature closure of the botanal duct, which can lead to the development of pulmonary hypertension in the newborn. Ibuprofen should not be used at the end (third trimester) of pregnancy. No ibuprofen excretion was detected with mother's milk. However, due to the limited scope of these studies and the possible adverse effect of inhibition of prostaglandin synthesis in the newborn, it is not recommended to use the drug during the breastfeeding period. With long-term use of Ibuprofen, periodic monitoring of the pattern of peripheral blood and the functional state of the liver and kidneys is recommended. At the onset of symptoms of gastropathy, careful monitoring is shown, including esophagogastroduodenoscopy, blood analysis with hemoglobin, hematocrit, fecal occult blood analysis. To prevent the development of NSAID-gastropathy, it is recommended to combine Ibuprofen with PG E (misoprostol) preparations.
With caution, the drug is prescribed to patients with impaired liver, kidney, cardiovascular diseases, with a history of gastric ulcer and / or duodenal ulcer, bleeding from the gastrointestinal tract.
Compared with other NSAIDs, Ibuprofen has the least ulcerogenic effect on the gastrointestinal mucosa.
With prolonged use of the drug, it is necessary to monitor the function of the liver and / or kidneys, the picture of peripheral blood.
In the case of overdose, which is manifested in increased signs of side effects, you should stop treatment and consult a doctor.
- Brand name: Ibuprofen
- Active ingredient: Ibuprofen
- Dosage form: Coated pills
- Manufacturer: Tatkhimpharmpreparaty
- Country of Origin: Russia
- Influence of water activity on the enantioselective esterification of (R,S)-ibuprofen by Candida antarctica lipase B in solventless media
- Polymeric drugs derived from Ibuprofen with improved antiinflammatory profile
- Preparation, characterization, and in vitro release of Ibuprofen from Al2O3/PLA/PMMA composites
- Catalytic conversions in water. Part 5: Carbonylation of 1-(4-isobutylphenyl)ethanol to ibuprofen catalysed by water-soluble palladium–phosphine complexes in a two-phase system
- Measurement of plasma ibuprofen by gas chromatography-mass spectrometry
- To the editor: Ibuprofen therapy in cystic fibrosis
- Resolution of enantiomers of ibuprofen by liquid chromatography: a review
- Separatory determination of diastereomeric ibuprofen glucuronides in human urine by liquid chromatography/electrospray ionization-mass spectrometry
- THE EFFECT OF FOOD ON THE BIOAVAILABILITY OF IBUPROFEN AND FLURBIPROFEN FROM SUSTAINED RELEASE FORMULATIONS
- Efficacy of Ibuprofen and Pentoxifylline in the Treatment of Phosgene-induced Acute Lung Injury
- Ibuprofen affects arylamine N-acetyltransferase activity in Helicobacter pylori from peptic ulcer patients
- Effects of ibuprofen on arylamine n -acetyltransferase activity in human colon tumor cells
- Synthesis of tritium-labelled metabolites of ibuprofen
- Baseline risk of gastrointestinal disorders among new users of meloxicam, ibuprofen, diclofenac, naproxen and indomethacin
- Spherical crystal agglomeration of ibuprofen by the solvent-change technique in presence of methacrylic polymers
- Synthesis, chromatographic resolution and chiroptical properties of carboxyibuprofen stereoisomers: Major metabolites of ibuprofen in man
- Preliminary pharmacokinetic study of ibuprofen enantiomers after administration of a new oral formulation (ibuprofen arginine) to healthy male volunteers
- Topical administration of racemic ibuprofen
- Stereoselective pharmacokinetics of ibuprofen in rats: effect of enantiomer-enantiomer interaction in plasma protein binding
- Stereoselectivity and enantiomer-enantiomer interactions in the binding of ibuprofen to human serum albumin
- Stereoselective allosteric binding interaction on human serum albumin between ibuprofen and lorazepam acetate
- Chiral discrimination in the transport of ketoprofen and ibuprofen esters through an aqueous phase mediated by various serum albumins
- Development of Sustained-Release Ibuprofen Microspheres Using Solvent Evaporation Technique
- Interaction of salicylate and ibuprofen with the carboxylic acid: CoA ligases from bovine liver mitochondria