Iodophenazone

Brand Pharmstandard

In stock 1596 Items

Available since: 2019-09-19

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Clinical Pharmacology

Pharmacological group: Antiviral agent.
Pharmaceutical action: Yodantipirin has anti-inflammatory, immunostimulating and interferonogenic properties. Stabilizes biological membranes and inhibits virus entry into the cell. It is an active inducer of alpha and beta interferon, stimulates cellular and humoral immunity. Active against tick-borne encephalitis virus, hemorrhagic fever with renal syndrome, vesicular stomatitis, influenza and parainfluenza.
Pharmacokinetics: Rapidly absorbed from the gastrointestinal tract, bioavailability is 80%. Up to 95% is metabolized in the liver. Excretion with urine through the kidneys through active transport to the renal tubules: 3-5% in unchanged form, 80-90% - inactive metabolites. It has a high affinity for tissue proteins at a therapeutic dose quickly passes from plasma albumin with a maximum concentration in the tissues in 10-12 hours. Binding to blood proteins is 25%. The half-life is about 6 hours.

Indications

Yodantipirin is used for the treatment and prevention of tick-borne encephalitis in adults, for the complex treatment of hemorrhagic fever with renal syndrome.

Composition

1 tab .:
- 1-phenyl-2,3-dimethyl-4-iodopyrazolone 100 mg
Excipients: potato starch, crystalline hydrated glucose, magnesium stearate, low molecular weight polyvinylpyrrolidone.

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Dosage and Administration

pills iodantipine taken after meals.
Prevention and treatment of tick-borne encephalitis.
Treatment:
- 0.3 g. (3 pills) - 3 times a day during the first 2 days;
- 0,2g. (2 pills) - 3 times a day for the next 2 days;
- 0.1 g. (1 tablet) - 3 times a day for the next 5 days.
Prevention:
a) after tick sucking:
- 0.3 g. (3 pills) - 3 times a day during the first 2 days;
- 0,2g. (2 pills) - 3 times a day for the next 2 days;
- 0.1 g. (1 tablet) - 3 times a day for the next 5 days.
b) during the stay in places associated with the possible suction of ticks:
- 0,2g. (2 pills) once a day for the entire period;
- 0,2g. (2 pills) 3 times a day for 2 days before visiting places associated with the possible suction of ticks.
Treatment of hemorrhagic fever with renal syndrome (HFRS).
The drug Yodantipirin should be prescribed for five days from the onset of the disease by 0.2 g (2 pills) 3 times a day for the first four days, then by 0.1 g. (1 tablet) 3 times a day for the next five days.

Adverse reactions

The drug is low toxic. It does not have mutagenic, embryotoxic, immunotoxic and allergenic effects. It is well tolerated, in some cases, possible dyspeptic phenomena, skin rash, itching, angioedema, and other allergic reactions. When you stop taking the drug, these reactions disappear.

Contraindications

Individual intolerance to jodantipirin and other iodine-containing drugs, hyperfunction of the thyroid gland.

Drug interactions

Antacids and H2 receptor antagonists reduce the absorbability of the drug and its action. When administered jointly with oral antidiabetic drugs, barbiturates, triceclic antidepressants, anticoagulants of indirect action, iodantipirin enhances their action, displacing them from their association with proteins.

Special instructions

In the treatment and prevention of tick-borne encephalitis is not recommended the combined use of yodantipirin and tick-borne immunoglobulin. In case of focal forms of tick-borne encephalitis, a specific immunoglobulin is first prescribed in the usual way, and after 2-3 days, jodantipyrine is administered in the indicated dosages.