Buy Ipigrix ampoules 15mg/ml 1.0 ml ampoule 10pcs
  • Buy Ipigrix ampoules 15mg/ml 1.0 ml ampoule 10pcs

Ipidacrine

Grindex
10000 Items
2019-06-23
Dosage form
Brand & Manufacturer
Package Size
$37.01
Quantity
  • done All payments are SSL encrypted
  • done Full Refund if you haven't received your order
  • done International shipping to the USA, UK and Europe

Clinical Pharmacology

Pharmacotherapeutic group: Anticholinesterase agents.

ATC CODE: N07AA

Pharmacological properties

Pharmacodynamics

Ipidacrine is a reversible inhibitor of cholinesterase. It directly stimulates the conduction of impulses in the central nervous system (CNS) and neuromuscular synapses, blocking the potassium channels of the membranes. Enhances the effect on smooth muscles not only of the mediator acetylcholine, but also of adrenaline, serotonin, histamine and oxytocin.

Main pharmacological effects of ipidacrine:

- restoration and stimulation of neuromuscular conduction;

- restoration of impulse conduction in the peripheral nervous system after blockade caused by certain factors (for example, trauma, inflammation, local anesthetics, antibiotics, toxins and potassium chloride);

- increased contractility and tone of the smooth muscles of the internal organs;

- specific moderate stimulation of the CNS in combination with individual manifestations of sedative action;

- memory improvement.

In preclinical studies, ipidacrine had no teratogenic, embryotoxic, mutagenic, carcinogenic, or immunotoxic effects, and did not affect the endocrine system.

Sufficient data from clinical studies of the safety of ipidacrine in children are not available.

Pharmacokinetics

Absorption

After oral administration, ipidacrine is rapidly absorbed from the gastrointestinal tract. The maximum concentration in plasma after subcutaneous or intramuscular administration is achieved within 25-30 minutes. About 40-55% of the active substance is bound to plasma proteins. The therapeutic effect appears 15–20 minutes after parenteral administration. The duration of the drug is 3-5 hours.

Distribution

The drug penetrates the blood-brain barrier. Ipidacrine rapidly enters the tissue, only 2% of the drug is found in the plasma in an equilibrium state.

Metabolism and excretion

The drug is metabolized in the liver. Ipidacrine excretion is renal and extrarenal (through the gastrointestinal tract), excretion with urine prevails. The half-life of ipidacrine is 40 min. After parenteral administration, 34.8% of the applied dose of ipidacrine is excreted unchanged in the urine. This indicates a rapid metabolism of the drug in the body.

Indications

- Diseases of the central nervous system: bulbar paralysis and paresis.

- Diseases of the peripheral nervous system (neuritis, polyneuritis, polyneuropathy, polyradiculopathy, myasthenia gravis and myasthenic syndrome of various etiologies).

- The period of recovery after organic lesions of the central nervous system, accompanied by motor impairment.

Composition

1 ml of solution contains:

active ingredient: ipidacrine hydrochloride monohydrate - 5.4 mg or 16.2 mg (in terms of ipidacrine hydrochloride - 5.0 mg or 15.0 mg);

excipients: 1 M solution of hydrochloric acid to pH 2.8-4.0, water for injection to 1 ml.

Description

Transparent colorless liquid.

Ipidacrine is marketed under different brands and generic names, and comes in different dosage forms:

Brand nameManufacturerCountryDosage form
Ipigrix Grindex Latvia ampoules
Ipigrix Grindex Latvia pills
Axamon Ellara Russia solution
Axamon Ellara Russia pills
Neuromidin Olainfarm Latvia ampoules
Neuromidin Olainfarm Latvia pills

No customer reviews for the moment.

Write your review

Write your review

Ipidacrine

Dosage and Administration

pills jodantipirina taken after meals.
Prevention and treatment of tick-borne encephalitis.
Treatment:
- 0.3 g. (3 pills) - 3 times a day during the first 2 days;
- 0,2g. (2 pills) - 3 times a day for the next 2 days;
- 0.1 g. (1 tablet) - 3 times a day for the next 5 days.
Prevention:
a) after tick sucking:
- 0.3 g. (3 pills) - 3 times a day during the first 2 days;
- 0,2g. (2 pills) - 3 times a day for the next 2 days;
- 0.1 g. (1 tablet) - 3 times a day for the next 5 days.
b) during the stay in places associated with the possible suction of ticks:
- 0,2g. (2 pills) once a day for the entire period;
- 0,2g. (2 pills) 3 times a day for 2 days before visiting places associated with the possible suction of ticks.
Treatment of hemorrhagic fever with renal syndrome (HFRS).
The drug Yodantipirin should be prescribed for five days from the onset of the disease by 0.2 g (2 pills) 3 times a day for the first four days, then by 0.1 g. (1 tablet) 3 times a day for the next five days.

Adverse reactions

The drug is low toxic. It does not have mutagenic, embryotoxic, immunotoxic and allergenic effects. It is well tolerated, in some cases, possible dyspeptic phenomena, skin rash, itching, angioedema, and other allergic reactions. When you stop taking the drug, these reactions disappear.

Individual intolerance to jodantipirin and other iodine-containing drugs, hyperfunction of the thyroid gland.

Drug interactions

Antacids and H2 receptor antagonists reduce the absorbability of the drug and its action. When administered jointly with oral antidiabetic drugs, barbiturates, triceclic antidepressants, anticoagulants of indirect action, iodantipirin enhances their action, displacing them from their association with proteins.

Special instructions

In the treatment and prevention of tick-borne encephalitis is not recommended the combined use of yodantipirin and tick-borne immunoglobulin. In case of focal forms of tick-borne encephalitis, a specific immunoglobulin is first prescribed in the usual way, and after 2-3 days, jodantipyrine is administered in the indicated dosages.

  • Brand name: Yodantipirin
  • Active ingredient: Iodophenazone
  • Dosage form: Pills
  • Manufacturer: Pharmstandard
  • Country of Origin: Russia

Studies and clinical trials of Ipidacrine (Click to expand)

8 other products in the same category:

arrow_upward