Isofra® [Framycetin]
Bouchard Laboratory
938 Items
2019-09-19
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Clinical Pharmacology
Aminoglycoside antibiotic for topical use in otorhinolaryngology. Bactericidal effect.
Active against gram-positive and gram-negative bacteria that cause the development of infectious processes in the upper respiratory tract.
Indications
As part of combination therapy in infectious and inflammatory diseases of the upper respiratory tract, including:
- Rhinitis.
- Rhinopharyngitis.
- Sinusitis (with no damage to the septum).
Prevention and treatment of inflammatory processes after surgery.
Composition
1 ml of nasal spray solution contains:
Active substance: framycetin sulfate - 12.5 mg (8 thousand IU);
Excipients: methyl parahydroxybenzoate, sodium chloride, citric acid, distilled water.
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Dosage and Administration
Adults: one spray in each nostril 4-6 times a day.
Children: one spray into each nostril 3 times a day.
The average duration of therapy is 7 days. When using the bottle should be kept upright.
Adverse reactions
Allergic reactions: in isolated cases - skin manifestations.
Contraindications
Hypersensitivity to framycetin and other aminoglycoside antibiotics.
Drug interactions
No clinically significant drug interactions with other drugs have been identified.
Pregnancy and Lactation
Adequate and strictly controlled clinical studies of the safety of the drug Isofra during pregnancy and lactation (breastfeeding) was not conducted.
Special instructions
If within 7 days of treatment the therapeutic effect is absent or weakly expressed, the drug should be withdrawn.
Overdosage
Due to the low degree of absorption into the systemic circulation, overdose is unlikely.
- Brand name: Isofra
- Active ingredient: Framycetin
- Dosage form: Nasal spray
- Manufacturer: Bouchard Laboratory
- Country of Origin: France
Studies and clinical trials of Framycetin (Click to expand)
- Analysis of neomycin sulfate and framycetin sulfate by high-performance liquid chromatography using evaporative light scattering detection
- Incidence of neomycin and framycetin sensitivity
- Anaphylactic reaction to framycetin (neomycin B) and lignocaine
- Allergic contact dermatitis following subconjunctival injection of framycetin
- Zur colorimetrischen Bestimmung von Framycetin
- Noncontrolled clinical trial of framycetin sulphate (Sofrakay) bacterial diarrhoea and cholera in children
- Staphylococcal nasal carriers treated with framycetin-gramicidin nasal spray
- Framycetin Sulphate in Small Animal Practice
- Fucithalmic® in acute conjunctivitis : Open, Randomized Comparison of Fusidic Acid, Chloramphenicol and Framycetin Eye Drops
- A prospective double-blinded comparative analysis of framycetin and silver sulphadiazine as topical agents for burns: A pilot study
- Influence of an Intramammary Infusion at Drying-Off of Combined Penethamate Hydriodide, Benethamine Penicillin, and Framycetin Sulfate on Intramammary Infections and Somatic Cell Counts in Dairy Sheep
- Severe anaphylactic reaction to topical administration of framycetin
- IN-VITRO ACTIVITY OF RISTOCETIN AND FRAMYCETIN TWO NEW ANTIBIOTICS
- CONTACT DERMATITIS FROM NEOMYCIN AND FRAMYCETIN
- CONTACT DERMATITIS FROM NEOMYCIN AND FRAMYCETIN
- TREATMENT OF THE NASAL CARRIER OF STAPHYLOCOCCUS AUREUS WITH FRAMYCETIN AND OTHER ANTIBACTERIALS
- Intraocular framycetin sulphate ointment after sutureless clear corneal section phacoemulsification
- In vitro susceptibility of bovine mastitis pathogens to a combination of penicillin and framycetin: Development of interpretive criteria for testing by broth microdilution and disk diffusion
- Chemistry of the Neomycins. V. Differentiation of the Neomycin Complex. Identity of Framycetin and Neomycin B. Compounds Obtained from Methyl Neobiosaminide B
- Neomycin/framycetin/gentamicin
- Framycetin
- Framycetin
- Corticosteroids/framycetin/gramicidin
- METHOD FOR THE PRESERVATION AND STERILIZATION OF FRESH DONOR MATERIAL FOR FULL-THICKNESS KERATOPLASTY BY FRAMYCETIN
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