Ketorolac

Brand S.K.Terapiya S.A.

In stock 1415 Items

Available since: 2019-09-19

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Clinical Pharmacology

Ketanov - nonsteroidal anti-inflammatory agent (NSAID).

It has anti-inflammatory and pronounced analgesic effect.

The mechanism of action is due to inhibition of the enzyme cyclooxygenase and inhibition of the synthesis of prostaglandins.

Ketanov has no sedative effect, does not affect opioid receptors.

Ketanov does not cause depression of the respiratory center and does not affect psychomotor functions.

Indications

Short-term relief of pain of various origins, including:

postoperative pain (including after abdominal, gynecological, orthopedic operations);
pain in sprains, fractures and injuries of soft tissues;
toothache (including after dental surgery);
postpartum pain;
pain syndrome in cancer;
pain syndrome in osteoarthritis;
sciatica.

Ketanov not indicated for use in chronic pain syndrome.

Composition

1 tablet contains Ketorolaka tromethamine 10 mg.

Ketorolac is marketed under different brands and generic names, and comes in different dosage forms:

Brand name	Manufacturer	Country	Dosage form
Ketanov	S.K.Terapiya S.A	Romania	pills
Ketanov	S.K.Terapiya S.A	Romania	solution
			solution
Ketorol	Dr. Reddy`s	India	pills
Ketorol	Dr. Reddy`s	India	solution
Dolac®	Cadilla	India	ampoules
Dolac®	Cadilla	India	pills
Ketocam®	Simppex Pharma	India	pills
Acuar LS®	Allergan	USA	eye drops
Ketorol	Dr. Reddy`s	India	gel
Ketorolac	K.O.Romparm Company S.R.L	Romania	solution

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Dosage and Administration

For adults inside appoint 10 mg every 4-6 hours.

With severe pain, the dose can be increased to 20 mg 3-4 times a day.

The maximum daily dose of the drug (for any dosage form) is 90 mg.

Adverse reactions

From the digestive system: stomatitis, nausea, constipation, dyspepsia, gastritis, erosive and ulcerative lesions of the gastrointestinal tract, dry mouth.

From the side of the central nervous system and peripheral nervous system: drowsiness, dizziness, nervousness, paresthesias.

From the urinary system: frequent urination, acute renal failure, nephrotic syndrome, interstitial nephritis.

Metabolism: increased levels of creatinine and / or urea in the blood plasma.

From the water and electrolyte balance: hypokalemia, hyponatremia.

Since the cardiovascular system: bradycardia, changes in blood pressure.

From the blood coagulation system: thrombocytopenia, purpura, hematoma formation, epistaxis, lengthening of clotting time.

On the part of the respiratory system: dyspnea.

Allergic reactions: hives.

Other: thirst.

Contraindications

peptic ulcer and duodenal ulcer in the acute phase;
gastrointestinal bleeding;
bronchial asthma;
severe cerebrovascular disorders;
moderate and severe renal dysfunction, the risk of developing renal failure with hypovolemia and dehydration;
history of blood coagulation disorders;
hemorrhagic diathesis;
simultaneous reception with other NSAIDs;
children and adolescents up to 16 years;
Hypersensitivity to ketorolac and other NSAIDs.

Drug interactions

With the simultaneous use of Ketanov with other NSAIDs increases the risk of side effects.

In vitro ketorolac reduces the binding of warfarin to plasma proteins.

Pregnancy and Lactation

Contraindicated in pregnancy and lactation.

Special instructions

It should be used with caution in patients with impaired liver and / or kidney function.

It should be borne in mind that with prolonged use of the drug increases the risk of side effects from the digestive system.

Ketanov does not cause the formation of drug dependence.

Overdosage

Clinical data on acute overdose of the drug is not.

ATexperimental studies After a single injection of 100 mg / kg of body weight, the animals showed symptoms such as decreased activity, diarrhea, difficulty breathing, and vomiting.