Lactobacillus acidophilic
Microgen NGO
1930 Items
2019-09-19
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Clinical Pharmacology
Lactobacterin has a broad spectrum antibacterial effect.
Pharmacodynamics
Living lactobacilli that are included in the drug have antagonistic activity against a wide range of pathogenic and conditionally pathogenic bacteria (including staphylococci, Proteus, enteropathogenic E. coli), normalize the digestive activity of the gastrointestinal tract, improve metabolic processes, help restore natural immunity.
Metabolize the glycogen of the vaginal epithelium to lactic acid, which maintains the pH of the vagina at 3.8–4.2.
Lactic acid in high concentration creates unfavorable conditions for the life of acid-sensitive pathogenic and conditionally pathogenic bacteria.
Indications
Indications In diseases of the gastrointestinal tract:
Composition
Active ingredient: lactobacillus acidophilic not less than 4 billion CFU
Excipients: components of the protective drying environment (gelatin, sucrose (sugar), milk).
Lactobacillus acidophilic is marketed under different brands and generic names, and comes in different dosage forms:
| Brand name | Manufacturer | Country | Dosage form |
|---|---|---|---|
| Lactobacterin dry | Microgen NGO | Russia | vials |
| Lactonorm (Lecco | Lecco | Russia | vaginal capsules |
| Ecofemin | Pharma Vinci | Denmark | vaginal capsules |
| Acylact | Lanafarm | Russia | suppositories |
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Dosage and Administration
Lactobacterin in case of intestinal diseases, they are used inside, and in obstetric-gynecological practice - intravaginally.
Dissolve the drug with boiled water at room temperature at the rate of 5 ml (a teaspoon) of water per 1 dose of the preparation.
In case of intestinal diseases, the drug should be taken 40-60 minutes before a meal and preferably drink milk. Treatment is recommended to accompany the use of vitamins.
In intestinal diseases, lactobacterin is used in the following daily doses:
| Age | Dose |
| Up to 6 months | 3 doses 2 times a day |
| From 6 months to 1 year | 3 doses 3 times a day |
| From 1 to 3 years | 5 doses 2 times a day |
| Older than 3 years and adults | 5 doses 2-3 times a day |
The course of treatment with lactobacterin for various diseases is:
- with prolonged and chronic course of dysentery, post-dysenteric colitis, follow-up treatment of convalescents after acute intestinal infections, as well as long-term intestinal dysfunction of unknown etiology, treatment - at least 4-6 weeks;
- in non-specific ulcerative colitis, as well as chronic colitis and enterocolitis - up to 2 months;
- with dysbacteriosis of various etiologies - 3-4 weeks.
In the absence of the effect of the use of the drug for 2 weeks, it is necessary to re-examine the microflora of the gastrointestinal tract and correct it with other drugs, depending on the result.
To consolidate the obtained clinical effect, or in the absence of a complete normalization of the microflora after the end of the course of treatment, for diseases with relapses, repeated courses of treatment are advisable. In these cases, before the appointment of the drug must be re-study of microflora. Maintenance doses of the drug (half the daily dose) are prescribed in 2-3 weeks for 1-1.5 months.
In case of inflammatory diseases of the genitalia, lactobacterin is prescribed in 5 doses, 2 times a day, intravaginally for 10-12 days, starting from 10-12 days of the menstrual cycle. For prenatal preparation of pregnant women at risk, Lactobacterin is prescribed in 5 doses 1 time per day for 5-8 days.
For intravaginal application, dissolve the contents of the vial in 5-10 ml of boiled water at room temperature, soak the sterile tampon with the dissolved preparation, insert the tampon into the vagina and leave for 2-3 hours.
The treatment is carried out under the control of restoring the purity of the vaginal secretions to grades I-II, the appearance of lactoflora and the disappearance of the clinical symptoms of the disease.
Adverse reactions
Allergic reactions.
Contraindications
Vulvovaginal candidiasis
Drug interactions
Due to the high antibiotic resistance of lactobacilli, it is allowed to use dry lactobacterin in antibiotic therapy.
Pregnancy and Lactation
Allowed
Special instructions
The dissolved drug is not subject to storage. A drug whose integrity in the packaging is broken (cracked vials), a drug without labeling, a drug with altered physical properties (discoloration, shrinking biomass), in the presence of inclusions, is unsuitable for use.
Influence on ability to drive motor transport and control mechanisms
None.
Overdosage
Not registered.
- Brand name: Lactobacterin dry
- Active ingredient: Lactobacillus acidophilic
- Dosage form: Powder for solution for oral administration and topical use
- Manufacturer: Microgen NGO
- Country of Origin: Russia
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