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Lactobacillus casei is a type of gram-positive rod-shaped anaerobic nonspore-forming bacteria.
Lactobacillus casei is a normal obligate flora of the oral cavity, intestines, vulva and vagina of a person.
Pharmacotherapeutic group: eubiotic
ATX code: G01AX14
Lactobacillus casei, along with other types of lactobacilli (L. acidophilus, L. fermentum, L. cellobiosum, etc.), are represented in the normal flora of the vulva and vagina of a woman. Colonization of the vagina with living chopsticks L. casei rhamnosus Doderleini creates a similar physiological environment in the vagina. The L. casei rhamnosus Doderleini strain in the Lactoginal® preparation has antagonistic activity against a wide range of pathogenic and conditionally pathogenic bacteria (including Staphylococcus spp., Proteus spp., Enteropathogenic Escherichia coli), improves local metabolic processes and contributes to the restoration of natural local immunity.
With the introduction of the capsule of the drug Lactofinal® into the vagina, the gelatin capsule shell dissolves with the release of a lyophilized culture of living lactobacilli. In vitro, it was shown that L. casei rhamnosus Doderleini lowered the pH over several hours. The specified property of L. casei rhamnosus Doderleini with the introduction of the drug into the vagina helps to restore its natural microflora.
Lactobacillus deficiency is one of the important factors in the development of candidal vulvovaginitis. Lactobacilli are physiological antagonists of yeast-like fungi of the genus Candida due to the secretion of antifungal substances and competition for receptors on the epithelial cells of the vagina (they suppress the attachment of Candida to the epithelial cells of the vagina, inhibit their growth and reproduction).
The results of a clinical study showed the effectiveness of the drug Lactofinal® in restoring the normal microflora of the vagina and preventing recurrent vulvovaginal candidiasis when it is used after the completion of antifungal therapy.
Restoration of normal microflora of the vagina after antibacterial therapy of bacterial vaginosis; in preparation for the planned gynecological operations; with prenatal preparation for pregnant women at risk of bacterial vaginosis.
The composition of one capsule
Lyophilized culture of lactobacilli L. casei rhamnosus Doderleini
at least 1x108 cfu of viable bacteria.
Excipients: potato starch ~ 139.810 mg, lactose monohydrate ~ 74.676 mg, sodium glutamate ~ 15.345 mg, sodium thiosulfate ~ 91.388 mg, magnesium stearate 3.410 mg;
Transparent gelatin capsules of size "0", filled with a light yellow powder with a brownish tint.
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Dosage and Administration
Dosing - intravaginally.
Insert the capsule deep into the vagina, wetting it in a small amount of water to accelerate the dissolution of the drug.
Restoration of normal microflora of the vagina after antibacterial therapy of bacterial vaginosis: one capsule in the morning and evening for 7 days or one capsule daily for 14 days.
In preparation for planned gynecological operations, prenatal preparation of pregnant women at risk for bacterial vaginosis: one capsule in the morning and evening for 7 days or one capsule daily for 14 days - as part of complex therapy.
The dosage regimen should be adjusted depending on the severity of the clinical effect.
Prevention of recurrence of vulvovaginal candidiasis (including exacerbations of recurrent vulvovaginal candidiasis) after local and / or systemic treatment with antifungal drugs: 1 capsule at night. The duration of drug therapy is determined by the doctor. The course of treatment should not exceed more than 21 days. The question of re-courses is decided individually.
Allergic reactions (including itching, burning, redness in the genital area; increased mucous discharge from the vagina).
- Hypersensitivity to the drug components
- Vulvovaginal candidiasis ("thrush")
- Children's age up to 18 years (efficiency and safety are not established).
It is not recommended to use the drug with spermicidal agents.
Simultaneous use with antibacterial, antiviral and immunomodulating drugs is possible.
No clinically significant interaction reported.
Pregnancy and Lactation
The drug Lactoginal® can be used during pregnancy and during breastfeeding.
After the introduction of the capsule dissolves, leaving no stains on the laundry or smell.
No cases of overdose have been reported.
- Brand name: Lactoginal®
- Active ingredient: Lyophilized culture of lactobacilli Lactobacillus casei rhamnosus Doderleini
- Dosage form: Vaginal Capsules
- Manufacturer: Bios Industry
- Country of Origin: France