Buy Tyzine allergy spray 50 mcg/dose 10 ml

Levocabastine

Brand Janssen Pharmaceuticals N.V.

In stock 1307 Items

Available since: 2019-09-19

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Clinical Pharmacology

Antihistamine, selectively blocks H1-histamine receptors. Reduces the severity of histamine-mediated allergic reactions.
Quickly eliminates the symptoms of allergic rhinitis (sneezing, itching in the nasal cavity, rhinorrhea) and improves nasal breathing (by reducing the swelling of the nasal mucosa).
No carcinogenic and mutagenic effects, and no effect on fertility. In doses exceeding the recommended for humans in 2500 times, has teratogenic activity (increases the frequency of embryo resorption).

Indications

Allergic rhinitis, pollinosis.

Composition

1 ml:
Levocabastine hydrochloride 540 mcg, which corresponds. Levocabastine 500 mcg
Excipients: propylene glycol - 48.26 μl, sodium hydrogen phosphate - 8.66 mg, sodium hydrogen phosphate monohydrate - 5.38 mg, hypromellose (2910 5 mPa.s) - 2.5 mg, polysorbate 80 - 1 mg, benzalkonium chloride - 150 μg (as a 50% solution - 30 mcl), disodium edetate - 150 mcg, water for injection - up to 1 ml.

Levocabastine is marketed under different brands and generic names, and comes in different dosage forms:

Brand name	Manufacturer	Country	Dosage form
Tyzine allergy	Janssen Pharmaceuticals N.V	Belgium	spray
Visine allergy	Johnson and johnson	USA	eye drops

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Dosage and Administration

Intranasally administered to adults and children over 6 years old, 2 doses (100 μg) in each nasal passage 2 times / day. Use of the drug should be continued until symptoms are eliminated. With more pronounced symptoms of the drug Tyzine allergy can be used 3-4 times / day.
The patient should be warned about the need to clear the nasal cavity before using the spray and inhale through the nose during the injection.
Before first use, remove the protective cap and repeatedly press the spray nozzle until a cloud of "fog" appears. The bottle is ready for further use. Drug inhale through the nose.
Shake the bottle before each use.

Adverse reactions

Adverse events reported in ≥1% of patients during clinical trials
On the part of the digestive system: nausea.
From the nervous system: headache, drowsiness, dizziness.
On the part of the respiratory system: pain in the pharynx and larynx, nosebleeds, cough.
Other: fatigue, pain at the injection site.
Adverse reactions that were noted in the Co side of the respiratory system: short-term local irritation, pain at the injection site, dryness, burning sensation, discomfort in the nasal cavity.
Post-marketing data:
Determination of the frequency of adverse reactions: very often (> 1/10), often (> 1/100, <1/10), infrequently (> 1/1000, <1/100), rarely (> 1/10 000, <1 1000="" very="" rarely="" 1="" 10="" 000="" including="" individual="" cases="" br="">Since the cardiovascular system: rarely - tachycardia.
On the part of the immune system: rarely - allergic reactions.
On the part of the respiratory system: rarely - swelling of the nasal mucosa; infrequently - shortness of breath; frequency is unknown - bronchospasm.
Other: infrequently - malaise; frequency is unknown - swelling of the eyelids.

Contraindications

- children's age up to 6 years;
- Hypersensitivity to the components of the drug Tyzine allergy.
Precautions should be prescribed the drug to patients with impaired renal function and elderly patients.

Pregnancy and Lactation

Reliable data on the use of nasal spray Tizin® Alergi in pregnant women are not available. Therefore, the drug should not be used during pregnancy unless the intended benefit to the mother justifies the potential risk to the fetus.
Based on the determination of the concentration of levocabastin in the saliva and breast milk of lactating women who once received 0.5 mg of levocabastin by mouth, it is expected that approximately 0.6% of the total intranasal dose of levocabastin can be administered to the infant during breastfeeding. If necessary, the appointment of the drug during lactation should stop breastfeeding.

Special instructions

Influence on ability to drive motor transport and control mechanisms
The drug Tizin Alerji in the recommended dose usually does not have a clinically pronounced sedative effect and does not reduce the speed of the reaction compared with placebo. In the case of drowsiness in the use of the drug should not engage in potentially hazardous activities that require increased attention and speed of psychomotor reactions.
Disposal rules:
The patient should be informed that if the drug has become unusable or the expiration date has expired, then it should not be thrown into the wastewater or on the street. It is necessary to put the drug in the bag and put it in the trash. These measures will help protect the environment.

Overdosage

No reports of overdose of levocabastin have been reported.
Symptoms: in case of accidental ingestion, a decrease in blood pressure, tachycardia, a slight sedation is possible.
Treatment: if ingested, the patient should drink a large amount of fluid to speed up the release of levocabastine by the kidneys.