Levofloxacin

Orally, before a meal or in a break between meals, without chewing, drinking a sufficient amount of liquid.
Acute sinusitis: 500 mg 1 time per day for 10-14 days;
Community-acquired pneumonia: 500 mg 1-2 times a day, 7-14 days;
Exacerbation of chronic bronchitis: 250-500 mg 1 time per day for 7-10 days;
Uncomplicated urinary tract infections - 250 mg 1 time per day for 3 days;
Complicated urinary tract infections (including pyelonephritis): 250 mg 1 time per day (for severe disease, the dose should be increased) for 7-10 days;
Chronic bacterial prostatitis - 500 mg 1 time per day, the course of treatment - 28 days;
Infections of the skin and soft tissues: 250-500 mg 1-2 times a day for 7-14 days;
Intraabdominal infection - 500 mg 1 time per day, treatment 7-14 days (in combination with antibacterial drugs acting on anaerobic microflora);
Combined therapy of drug-resistant forms of tuberculosis: 500 mg 1-2 times a day, the course of treatment is up to 3 months;
The duration of treatment depends on the type and severity of the disease.
After stopping the symptoms of acute inflammation and normalizing the temperature, it is recommended to continue therapy with levofloxacin for 48-72 hours.

Dosing of the drug in patients with impaired renal function (creatinine clearance less than 50 ml / min):

• • 50-20 ml / min:
    Initial dose of 250 mg / 24 h: further 125 mg / 24 h;
    Initial dose of 500 mg / 24 h: further 250 mg / 24 h;
    Initial dose of 500 mg / 12 h: further 250 mg / 12 h;

• • 19-10 ml / min:
    Initial dose of 250 mg / 24 h: further 125 mg / 48 h;
    Initial dose of 500 mg / 24 h: further 125 mg / 24 h;
    Initial dose of 500 mg / 12 h: further 125 mg / 12 h;

• ? 10 * ml / min:
  Initial dose of 250 mg / 24 h: further 125 mg / 48 h;
  Initial dose of 500 mg / 24 h: further 125 mg / 24 h;
  Initial dose of 500 mg / 12 h: further 125 mg / 24 h;

* including with hemodialysis and continuous ambulatory peritoneal dialysis

After hemodialysis or permanent ambulatory peritoneal dialysis, no additional doses are required.
Dose adjustment is not required in patients with impaired liver function.

In the treatment of elderly patients should be borne in mind that they often suffer from impaired renal function.
Despite the fact that photosensitivity during treatment with levofloxacin is rarely observed, patients are not recommended to undergo strong solar or artificial ultraviolet radiation.
If pseudomembranous colitis is suspected, you should immediately cancel levofloxacin and begin appropriate treatment. In such cases, you can not use drugs that inhibit intestinal motility.
Patients with glucose-6-phosphate dehydrogenase deficiency (a hereditary metabolic disorder) can respond to fluoroquinolones by destroying red blood cells (hemolysis). In this regard, treatment with levofloxacin should be carried out with caution.
Side effects of levofloxacin, such as dizziness or drowsiness, as well as visual impairment (see the “Side Effects” section), can impair reactivity and hamper driving and maintaining machinery.

Symptoms of a drug overdose of levofloxacin appear at the level of the central nervous system (confusion, dizziness, impaired consciousness and convulsions). In addition, gastrointestinal disorders (eg, nausea, vomiting) and erosive lesions of the mucous membranes of the gastrointestinal tract may occur. In studies conducted with ultra-high doses of levofloxacin, prolongation of the QT interval has been shown.
Levofloxacin is not eliminated by hemodialysis or peritoneal dialysis. There is no specific antidote (opposing agent).
Treatment - gastric lavage and symptomatic therapy.