Lydase®

For cicatricial lesions of the skin tissue (under the scar-modified tissue) or intramuscular (near the lesion site), 64 IU (1 ml) are administered daily or every other day (10-20 injections in total). In traumatic lesions of the nerve plexuses and peripheral nerves, SC is injected into the region of the affected nerve (64 UE in procaine solution) every other day; 12-15 injections per course. The course of treatment is repeated if necessary. When used in ophthalmic practice, a 0.1% solution is instilled simultaneously with the use of antibacterial drugs (sulfonamides, antibiotics). When retinopathy is also injected under the skin of the temple; with hemorrhages in the vitreous - under the conjunctiva and / or retrobulbar. Patients with pulmonary tuberculosis with a productive inflammation are prescribed in complex therapy to increase the concentration of antibacterial substances in the lesions in the form of injections and / or inhalations. Inhalation is carried out daily 1 time, using 5 ml of solution (320 UE). The course of treatment consists of 20-25 inhalations. If necessary, repeat courses are conducted at intervals of 1.5-2 months. Outwardly, in the form of dressings soaked in a solution of the drug. To prepare a solution, each 64 IU is dissolved in 10 ml of sterile 0.9% sodium chloride solution or boiled water at room temperature. This solution moistened with a sterile dressing, folded in 4-5 layers, put it on the affected area, covered with wax paper and fixed with a soft dressing. The dose depends on the area of ​​the lesion (20-60 IU / square cm), an average of 300 IU per dressing. The bandage is applied daily for 15-18 hours for 15-60 days. With prolonged use every 2 weeks make a break for 3-4 days. When using the method of electrophoresis, 300 IU is dissolved in 60 ml of distilled water, add 2-3 drops of 0.1% hydrochloric acid solution and injected from the anode to the affected area within 20-30 minutes. The course of treatment is 15-20 sessions. The application mode dosing can be alternated with electrophoresis. The prepared solution should be used within 24 hours.

The solution should not be administered through a catheter into which solutions containing cations were previously injected. Solutions for injections are prepared with a 0.9% solution of sodium choride or 0.5% solution of procaine, for inhalations with a 0.9% solution of sodium chloride, for electrophoresis with distilled water. Before starting treatment, it is advisable to conduct a test with intracutaneous administration of 20 μl of hyaluronidase. Do not enter into areas of infectious inflammation and tumors.

Symptoms: chills, nausea, vomiting, dizziness, tachycardia, lowering blood pressure, local edema, urticaria, erythema.

Treatment: the introduction of epinephrine, GCS; antihistamine drugs.