Lidocaine, Prilocaine

Externally, on the skin or mucous membrane.

Surface anesthesia of trophic ulcers of the lower extremities

During surgical treatment (mechanical cleaning) of trophic ulcers of the lower extremities: a single dose of about 1-2 g / 10 cm2; apply a thick layer of cream on the ulcer surface, not more than 10 g of cream per procedure. Apply an occlusive dressing. Application time: at least 30 minutes.

The opened cream tube is intended for single use, the tube with cream residues should be discarded after use in one patient.

In the case of the treatment of ulcers, in the tissues of which the penetration of the preparation is difficult, the duration of application can be increased to 60 minutes. Mechanical cleaning should be started no later than 10 minutes after removing the cream.

When manipulating the ulcers of the lower extremities, the drug was used up to 15 times over a period of 1-2 months without reducing the effectiveness and increasing the frequency of local reactions.

Genital anesthesia

Skin genitals:

Pain relief before injections of local anesthetics:

Males: 1 g / 10 cm2. Apply the cream with a thick layer on the skin. Application time: 15 min.

Females: 1-2 g / 10 cm2. Apply the cream with a thick layer on the skin. Application time: 60 min.

Surface anesthesia of the mucous membrane of the genital organs:

When removing condylomas and for anesthesia before injections of local anesthetics: approximately 5-10 g of cream, depending on the area of ​​the treated surface. Cream should be applied to the entire surface of the mucous membrane, including the folds of the mucous membrane. Occlusive dressings are required. Application time: 5-10 min. Perform the procedure immediately after removal of the cream.

Children

Anesthesia with the introduction of the needle (including with vaccination), with curettage of molluscum contagiosum and other small surface surgical procedures.

Apply the cream with a thick layer on the skin and cover with an occlusive dressing. The dose should correspond to the treated surface and should not exceed 1 g of cream per 10 cm2.

The strip of the drug Acriol Pro 3.5 cm long approximately corresponds to a dose of 1 g. An increase in the time of application reduces anesthesia.

In children with atopic dermatitis, the application time should be reduced to 30 minutes. Apply the cream with a thick layer on the skin and cover with an occlusive dressing.

Recommendations for applying the drug

Pierce the protective membrane of the aluminum tube using a screw cap, squeeze a sufficient amount of cream from the tube and apply it to the place of the proposed procedure.

With anesthesia of the skin may use occlusive stickers. For anesthesia of trophic ulcers of the lower extremities, use an occlusive PVC dressing. Cover the applied cream with a bandage so that the layer of cream under it is thick and does not squeeze out from under the bandage. Smooth the edges of the dressing gently to avoid cream leaks.

After the recommended time, remove the dressing and cream residue from the surface.

Pregnancy

Not enough data on the use of the drug in pregnant women. In the course of animal studies, no direct or indirect adverse effects of the drug on pregnancy, fetal development, on the process of childbirth or postnatal development were revealed. Lidocaine and prilocaine penetrate the placental barrier and can be absorbed in the tissues of the fetus. No specific disturbances of the reproductive process, such as an increase in the frequency of malformations or other direct or indirect adverse effects on the fetus, were reported.

Breastfeeding period

Lidocaine and prilocaine are excreted in breast milk in amounts that do not represent a risk to the child, when using the drug in therapeutic doses.

Patients with glucose-6-phosphate dehydrogenase deficiency or hereditary or idiopathic methemoglobinemia are more susceptible to drug-dependent methemoglobinemia.

The efficacy of using the drug in newborns during the procedure of taking blood samples from the heel has not been established.

Care should be taken when applying the drug Acriol Pro around the eyes, because the drug causes eye irritation. Removing protective reflexes can cause irritation or corneal damage. In case of contact with eyes, immediately flush eyes with water or 0.9% sodium chloride solution, and protect eyes until protective reflexes are restored.

Care must be taken when applying the drug to the skin with atopic dermatitis; the application time should be reduced (15-30 minutes).

In children under the age of 3 months, the safety and efficacy of the drug was determined after the application of a single dose. In these children, after application of the drug, a temporary increase in blood levels of methemoglobin up to 13 hours was often observed. However, the observed increase in blood levels of methemoglobin probably has no clinical significance.

Patients taking class III antiarrhythmic drugs (eg, amiodarone) should be monitored and monitored ECG, since may affect the heart activity.

The drug should not be applied to the damaged eardrum or in other cases of possible penetration of the drug into the middle ear.

Do not apply the drug Acriol Pro on open wounds.

Due to the lack of data on the absorption of the drug is not recommended to apply the drug on the mucous membrane of the genital organs in children.

Lidocaine and prilocaine in concentrations above 0.5-2% have bactericidal and antiviral properties. In this regard, it is recommended to take special care when using the drug before the subcutaneous administration of a live vaccine (for example, BCG).

Due to the lack of data, the combined use of the drug Acriol Pro and drugs that cause methemoglobinemia in children aged 0 to 12 months is not recommended.

If the recommended dosage regimen is observed, the development of signs of systemic toxicity is unlikely.

The symptoms of intoxication are probably the same as with other local anesthetics, for example, central nervous system (CNS) arousal, and in severe cases, CNS depression and heart activity.

In rare cases, the development of clinically significant methemoglobinemia was noted. Prilocaine in high doses may cause an increase in methemoglobin. Surface application of 125 mg of prilocaine for 5 hours caused the development of moderate methemoglobinemia in a 3-month-old baby. Superficial application of lidocaine at a dose of 8.6-17.2 mg / kg caused severe intoxication in the newborn.

Treatment: Severe neurological symptoms (convulsions, depression of the central nervous system) require symptomatic treatment, including prescription.

anticonvulsant drugs and, if necessary, mechanical ventilation. In the case of the development of methemoglobinemia, the antidote is methylthioninium chloride (methylene blue).

Because of the slow systemic absorption of the drug, patients should be monitored for several hours after the start of treatment of intoxication.