Lomexin® [Fenticonazole]
Record Chemical and Pharmaceutical Industry
710 Items
2019-09-19
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Clinical Pharmacology
Lomexin is an antifungal local.
It has fungistatic and fungicidal action. It also has antibacterial and anti-inflammatory effects.
Pharmacodynamics
The mechanism of action is to inhibit the biosynthesis of ergosterol, which is part of the cell membrane of the fungus, which leads to changes in its structure and properties. Active against yeast-like fungi (includingCandida albicans) and gram-positive bacteria.
Pharmacokinetics
Practically not subjected to systemic absorption, with prolonged external use, its concentration in the blood is not determined. The degree of absorption of mucous membranes is extremely small.
Indications
Vulvovaginal candidiasis; vaginal trichomoniasis.
Composition
1 g of cream contains:
Active substance: fenticonazole nitrate 2 g;
Excipients: propylene glycol - 5 g; hydrogenated lanolin - 1 g; almond oil - 10 g; cetyl alcohol - 3 g; glycerol monostearate - 3 g; sodium edetate - 0.5 g; polyglycolic ester of fatty acids - 15 g; purified water - 60 g
Fenticonazole is marketed under different brands and generic names, and comes in different dosage forms:
| Brand name | Manufacturer | Country | Dosage form |
|---|---|---|---|
| Lomexin | Record Chemical and Pharmaceutical Industry | Italy | cream |
| Lomexin | Record Chemical and Pharmaceutical Industry | Italy | vaginal capsules |
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Dosage and Administration
A topical cream of about 5 g is injected deep into the vagina 1 time per day, in the evening or, if necessary, 2 times per day (morning and evening). The treatment is carried out until complete clinical recovery.
Adverse reactions
Allergic reactions: rarely - urticaria, rash, erythema.
Local reactions: burning, itching, local irritation.
Contraindications
I trimester of pregnancy; hypersensitivity to the drug.
Special instructions
With prolonged use of the drug may develop sensitization. In this case, it is necessary to discontinue treatment, and the patient should contact your doctor.
In the absence of effect within 3 weeks of therapy, treatment should be discontinued and the diagnosis clarified.
The drug should not be prescribed during menstruation. The course of treatment is advisable to start after menstruation.
In order to avoid reinfection, it is recommended to simultaneously treat the partner with cream, which is applied to the glans penis and the foreskin.
- Brand name: Lomexin
- Active ingredient: Fenticonazole
- Dosage form: Vaginal cream
- Manufacturer: Record Chemical and Pharmaceutical Industry
- Country of Origin: Italy
Studies and clinical trials of Fenticonazole (Click to expand)
- Determination of fenticonazole and its impurities by capillary electrophoresis and high performance liquid chromatography
- The development and validation of a high performance liquid chromatography (HPLC)/tandem mass spectrometry assay for fenticonazole in human plasma and comparison with an HPLC-UV method
- In vitroactivity of cloconazole, sulconazole, butoconazole, isoconazole, fenticonazole, and five other antifungal agents against clinical isolates ofCandida albicansandCandidaspp.
- Study of the Morphofunctional Alterations Produced by Fenticonazole on Strains of Candida albicans, using the Scanning Electron Microscope (S. E. M.) : Untersuchung der durch Fenticonazole bei Candida albicans bewirkten morphologisch-funktionellen Veränderungen mit dem Rasterelektronenmikroskop
- Fenticonazole: A New Antifungal Imidazole Derivative In Vitro and In Vivo Antimycotic Activity : Fenticonazol: ein neuer Imidazol-Abkömmling. In vitro und in vivo antimykotischer Wirkung.
- Fenticonazole: A Clinical Trial: Fenticonazol: Ein klinischer Versuch
- Evaluation of the Antifungal Activity of Fenticonazole on Strains of Candida albicans on Cellular Lines: Untersuchung der antimyzetischen Aktivität von Fenticonazol bei Candida albicans in Zellkulturen
- A Double Blind Evaluation of Fenticonazole Cream 2% and Clotrimazole Cream 1% in Dermatomycoses/Doppelblindstudie mit Fenticonazol-Creme 2%ig und Clotrimazol-Creme 1%ig bei Dermatomykosen
- Treatment of Dermatomycoses with Topical Fenticonazole and Econazole/Lokalbehandlung von Dermatomykosen mit Fenticonazol und Econazol
- New Therapeutic Approach in Skin Mycoses: A Comparative Trial Once Versus Twice Daily Applications of Fenticonazole in Comparison to Miconazole/Neuer Therapieansatz bei Hautmykosen: Studie über die tägliche Einmal- und Zweimal-anwendung von Fenticonazol im Vergleich mit Miconazol
- Recurrent tinea pedis: a double blind study on the prophylactic use of fenticonazole powder : Rezidivierende Tinea pedis: Eine Doppelblindstudie zur prophylaktischen Anwendung von Fenticonazol-Puder
- Evaluation of the irritation and contact-sensitizing potential of fenticonazole
- Evaluation of the efficacy and tolerability of two different dosages of fenticonazole vaginal ovules (600 mg and 1000 mg) in patients with vaginal trichomoniasis: A controlled, double-blind, randomized clinical trial versus placebo
- Comparative Clinical Trial of Fenticonazole Ovule (600 mg) Versus Clotrimazole Vaginal Tablet (500 mg) in the Treatment of Symptomatic Vaginal Candidiasis
- Topical Fenticonazole in Dermatology and Gynaecology
- A double-blind clinical trial of fenticonazole (2%) spray versus naftifine (1%) spray in patients with cutaneous mycoses
- Fenticonazole: world first launch of Recordati's antifungal in Italy
- Fenticonazole or Clotrimazole for Vaginal Candidiasis?
- Fenticonazole: cream works rapidly to heal dermatomycoses
- Fenticonazole: provides rapid relief from symptoms of vulvovaginal candidiasis and is as effective as miconazole
- Fenticonazole and cyclopyroxolamine are equally effective in cutaneous mycoses
- Single Dose Therapy of Vaginal Candidiasis: A Comparative Trial of Fenticonazole Vaginal Ovules Versus Clotrimazole Vaginal Tablets
- Clinical evaluation of fenticonazole cream in cutaneous fungal infections: a comparison with miconazole cream
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