Loratadine

Brand Sandoz

In stock 736 Items

Available since: 2019-09-19

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Clinical Pharmacology

Lomilan is a histamine H1 receptor blocker for systemic use. It has antiallergic, antipruritic and antiexudative action.
Reduces capillary permeability, prevents the development of tissue edema, relieves spasms of smooth muscles.
Does not affect the central nervous system and is not addictive. The effect of the drug begins 30 minutes after administration, reaches a maximum after 8-12 hours and lasts for 24 hours.

Indications

Prevention and treatment of the following diseases and conditions:
- seasonal and perennial allergic rhinitis;
- allergic conjunctivitis;
- treatment of skin diseases of allergic genesis (including chronic idiopathic urticaria);
- pseudo-allergic reactions;
- allergic reactions to insect bites.

Composition

1 tablet contains Loratadine - 10 mg;
Excipients: lactose, corn starch, gelatinized starch, magnesium stearate.

Loratadine is marketed under different brands and generic names, and comes in different dosage forms:

Brand name	Manufacturer	Country	Dosage form
Lomilan	Sandoz	Switzerland	pills
Loratadin-Teva	Teva	Israel	pills
Clarosens	Pharmstandard	Russia	pills
Loratadine	Vertex	Russia	pills
Loratadine	Nizhpharm/Hemofarm	Serbia	pills
LoraHexal®	Sandoz	Switzerland	pills
Clarosens syrup	Pharmstandard	Russia	syrup
Claritin	Bayer Pharma AG	Germany	pills
Claritin	Bayer Pharma AG	Germany	syrup

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Dosage and Administration

Adults and children over 12 years old, as well as younger children weighing more than 30 kg, are prescribed 1 tablet 1 time per day.

For patients with impaired liver function or renal failure, the initial dose of the drug is 10 mg every other day.

pills are taken orally (possibly simultaneously with a meal), drinking water or milk. If necessary, the tablet can be chewed.

Children under 12 years old are recommended to use the suspension.

Adverse reactions

In adults: dry mouth, nausea, gastritis, headache, fatigue, drowsiness; rarely, liver dysfunction, allergic reactions (rash), anaphylactic reactions, alopecia.
In children: rarely - headache, nervousness, sedation.

The frequency of these side effects with Lomilan was at the same level as with placebo.

Contraindications

Hypersensitivity to all components of the drug (pills or suspensions).

WITH caution prescribe the drug for liver failure. There is no data on the safety and efficacy of Lomilan in children under 2 years of age.

Drug interactions

With simultaneous use with ketoconazole and cimetidine concentration of loratadine in the blood increases.
The simultaneous intake of microsomal oxidation inducers (phenytoin, ethanol, barbiturates, rifampicin, tricyclic antidepressants) reduces the effectiveness of loratadine.

Pregnancy and Lactation

Use of Lomilan during pregnancy is possible only when the intended benefit to the mother outweighs the potential risk to the fetus.
Loratadine is excreted in breast milk, so if necessary, the appointment of the drug during lactation should decide on the termination of breastfeeding.

Special instructions

The drug should be discontinued at least 2 days before skin allergy tests, because Lomilan can influence their results.

Influence on ability to drive motor transport and control mechanisms
There are no data on the negative effect of Lomilan in recommended doses on the ability to drive a car or work with mechanisms. However, when using Lomilan in doses higher than recommended, or when nonstandard effects appear after taking the drug, care should be taken when practicing potentially hazardous activities that require high concentration of attention and speed of psychomotor reactions.

Overdosage

Symptoms: headache, drowsiness, palpitations that can last a long time.
Treatment: when taking an excessive amount of Lomilan, remove the drug from the gastrointestinal tract as soon as possible and, if possible, reduce its absorption (gastric lavage, taking activated charcoal). There is no specific antidote.