Magaldrate, Simethicone

Brand Sequel Pharmaceuticals Pvt.Ltd.

In stock 938 Items

Available since: 2019-09-19

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Clinical Pharmacology

Combined drug, the action of which is due to the properties of its constituent components. It has antacid, adsorbing, enveloping, carminative effect.

Magaldrat

Magaldrat (aluminum magnesium hydroxide sulfate) neutralizes free hydrochloric acid in the stomach without causing secondary hypersecretion of gastric juice. Due to the increase in pH when it is taken, the peptic activity of the gastric juice decreases. It has an adsorbing and enveloping effect, which reduces the impact of damaging factors on the gastric mucosa, binds bile acids.

Simethicone

Simethicone changes the surface tension of gas bubbles formed in the contents of the stomach and intestinal mucus, and causes their destruction. The gases released during this process can be absorbed by the cells of the intestinal walls, or excreted due to peristalsis. Simethicone removes the foam in a purely physical way, does not enter into chemical reactions, is pharmacologically inert.

Pharmacokinetics:

Magaldrat

The absorption of aluminum and magnesium ions in the blood is low. With normal kidney function, the concentration of aluminum and magnesium in the blood does not change. In patients with chronic renal insufficiency, the content of aluminum and magnesium in the blood may increase to toxic values as a result of impaired excretion.

Simethicone

Simethicone due to pharmacological and chemical inertness after oral administration is not absorbed into organs and tissues. After passing through the gastrointestinal tract (GIT) is excreted unchanged by the intestine.

Indications

Symptoms associated with increased acidity of gastric juice and reflux esophagitis: heartburn, belching "sour taste", pain in the stomach (occur irregularly), feeling of fullness or heaviness in the epigastric region, flatulence, dyspepsia (including those caused by an error in diet , medication, alcohol abuse, coffee, nicotine).

Composition

1 tablet chewable dosage of 800/40 mg contains:

Active substances: galgaldrate - 800 mg, simethicone (in terms of dimethylpolysiloxane) - 61.54 (40) mg.

Excipients: ethylcellulose - 36.00 mg, macrogol - 4000 - 140.0 mg, sorbitol - 513.18 mg, sucralose - 4.32 mg, aspartame - 5.0 mg, caramel flavoring - 12.96 mg, silicon dioxide colloid - 9.0 mg, glyceryl dibehenate - 18.0 mg.

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Dosage and Administration

For oral use. pills should be thoroughly chewed or kept in mouth until complete.

resorption.

Adults and teenagers over 12 years old: unless otherwise recommended by a doctor, 1 -2 pills

take a short time after meals. If necessary, you can repeat the reception

drug after 2 hours.

The maximum daily dose for pills 800/40 mg - 8 pills.

Adverse reactions

Allergic reactions, nausea, vomiting, a violation of taste, constipation, diarrhea. With long-term intake in high doses - hypophosphatemia, hypocalcemia, hypercalciuria, osteomalacia, osteoporosis, hypermagnemia, hyperaluminiemia, encephalopathy, nephrocalcinosis, impaired renal function. In patients with concomitant renal insufficiency - feeling of thirst, lowering blood pressure, hyporeflexia.

Contraindications

Hypersensitivity to the drug; severe renal failure; hypophosphatemia; fructose intolerance (due to the presence of sorbitol in the formulation); children's age up to 12 years.