Magnesium orotate

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Available since: 2019-09-19

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Clinical Pharmacology

Magnesium is an essential trace element, is involved in the implementation of more than 300 enzymatic reactions, regulation of cellular permeability and neuromuscular excitability. Necessary to ensure many energy processes, is involved in the metabolism of proteins, fats, carbohydrates and nucleic acids. Magnesium has a curare-like effect on the terminations of cholinergic neurons, with a decrease in acetylcholine release. Magnesium and calcium interact in the body partially synergistically: however, with competitive inhibition of calcium, magnesium can also affect binding sites as a physiological calcium antagonist.

Indications

Established magnesium deficiency, isolated or associated with other deficient conditions, accompanied by symptoms such as: - increased fatigue; - irritability; - tingling sensation in the muscles. - minor sleep disorders; - gastrointestinal spasms; - pain and muscle spasms; If after a month of treatment there is no reduction of these symptoms, the continuation of treatment is inappropriate.

Composition

1 tablet contains:
active ingredient: magnesium orotate dihydrate 500 mg;
excipients: lactose monohydrate, corn starch, microcrystalline cellulose, povidone K-30, croscarmellozan sodium, colloidal silicon dioxide (aerosil), sodium cyclamate, talc, magnesium stearate.

Magnesium orotate is marketed under different brands and generic names, and comes in different dosage forms:

Brand name	Manufacturer	Country	Dosage form
			pills
Magnerot	Verwag Pharma	Germany	pills

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Dosage and Administration

Orally, before meals, with a small amount of liquid. take 2 pills 3 times / day for 7 days, then 1 tablet 2-3 times daily. Duration of treatment is 4 weeks.

Adverse reactions

On the part of the gastrointestinal tract: unstable stools and diarrhea, which usually pass on their own at lower doses of the drug. On the part of the immune system: allergic reactions.

Contraindications

- hypersensitivity to the drug; - urolithiasis disease; - renal dysfunction; - predisposition to the formation of calcium-magnesium-ammonium phosphate stones; - cirrhosis of the liver with ascites; - children's age up to 18 years. The drug contains lactose, so you should not use it in patients with lactose intolerance, lactase deficiency or glucose-galactose malabsorption.

Drug interactions

At the same time taking magnesium-containing preparations with preparations of iron, sodium fluoride and tetracyclines may decrease the absorption of the latter. In addition, aminoquinolines, quinidine, penicillamine should not be administered simultaneously with magnesium preparations. Therefore, you should take these drugs with an interval of 2-3 hours. Oral contraceptives, diuretics, muscle relaxants, GCS, insulin, reduce the effect of the drug. Magnesium should be used with caution when using magnesium-containing drugs, such as antacids or laxatives, or potassium-saving diuretics or drugs containing calcium. With simultaneous use with preparations containing aluminum, the absorption of aluminum in the body can be increased. Magnesium should be used with caution when used in combination with digitalis preparations, since simultaneous use may interfere with the absorption of digitalis preparations. Some antibiotics (aminoglycosides), cisplatin and cyclosporin A can lead to increased excretion of magnesium. Some diuretics (thiazides and furosemide), cetuximab and erlotinib, proton pump inhibitors (omeprazole and Pantoprazole), foscarnet, pentamidine, rapamycin and amphotericin B can cause magnesium deficiency, and thus reduce the effect of the drug.

Special instructions

The drug contains lactose monohydrate, so its use is not recommended for patients with hereditary galactosemia, malabsorption of glucose and galactose and lactase deficiency. Influence on ability to drive vehicles and mechanisms The drug does not affect the ability to drive vehicles, mechanisms and engage in other activities that require high concentration of attention and speed of psychomotor reactions.

Overdosage

With normal kidney function, ingestion of magnesium does not cause toxic reactions. Magnesium poisoning can develop in renal failure. Toxic effects mainly depend on serum magnesium concentration. Symptoms: decreased blood pressure, nausea, vomiting, depression, slow reflexes, respiratory depression, coma, cardiac arrest, anuric syndrome. Treatment: rehydration, forced diuresis. In renal insufficiency, hemodialysis or peritoneal dialysis is necessary.