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Magnesium, Pyridoxine

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Clinical Pharmacology

Magnesium is a vital element that is necessary for the normal functioning of cells and is involved in most metabolic reactions. In particular, it is involved in regulating the transmission of nerve impulses and in muscle contraction. 1/3 of the amount of magnesium contained in the body accumulates in the bone tissue. The body gets magnesium with food. Lack of magnesium in the body can be observed in violation of the diet (diet), with an increase in the need for magnesium or imbalance of admission, metabolism and excretion of magnesium (for example, with increased physical and mental stress, stress, during pregnancy, when using diuretics).
Pyridoxine (vitamin B6) is involved in many metabolic processes, improves the absorption of magnesium from the gastrointestinal tract and its penetration into cells.
Serum magnesium levels:
Between 12 and 17 mg / l (1 - 1.4 mEq / l or 0.5 - 0.7 mmol / l): indicate a moderate magnesium deficiency;
Below 12 mg / l (1 mEq / l or 0.5 mmol / l): indicate severe magnesium deficiency.
Gastrointestinal absorption of magnesium salts occurs partly by a passive mechanism in which the solubility of the salt plays a decisive role. The extent of this absorption does not exceed 50%. Excretion occurs mainly by the kidneys.


Established magnesium deficiency, isolated or associated with other deficient conditions, accompanied by symptoms such as:

  • irritability,
  • minor sleep disturbances
  • gastrointestinal cramps,
  • cardiopalmus,
  • increased fatigue
  • muscle aches and cramps
  • tingling sensation in muscles.

If after a month of treatment there is no reduction of these symptoms, the continuation of treatment is inappropriate.


1 tablet contains

Tablet core:

  • active ingredients:
    • magnesium citrate - 618.43 mg, which corresponds to 100 mg of magnesium (mg ++),
    • pyridoxine hydrochloride - 10.00 mg;
  • Excipients:
    • lactose - 50,57 mg,
    • macrogol-6000 - 120.00 mg,
    • magnesium stearate - 1.00 mg.

Tablet shell:

  • hypromellose 6 mPa.s - 14.08 mg,
  • macrogol-6000 - 1.17 mg,
  • titanium dioxide (E 171) - 4.75 mg,
  • talc - traces.

Magnesium, Pyridoxine is marketed under different brands and generic names, and comes in different dosage forms:

Brand nameManufacturerCountryDosage form
Magne B6 Sanofi-aventis France pills
Magne B6 Sanofi-Aventis France, France, Hungary pills
Magnelis B6 Forte Pharmstandard-Tomsk Russia pills
Magnistad Stada Germany pills
Magnelis B6 Pharmstandard Ufavita Russia pills
Magnerot Verwag Pharma Germany pills
Magne B6 Sanofi-aventis France solution

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Magnesium, Pyridoxine

Dosage and Administration

pills should be taken whole with a glass of water.
Adults: 3-4 pills per day, divided into 2-3 doses, with meals.
Children over 6 years old (weighing about 20 kg):
10-30 mg / kg / day (0.4–1.2 mmol / kg / day), that is, children over 6 years old (weighing about 20 kg) 2-4 pills per day, divided into 2-3 doses, during food Time.
Usually the duration of treatment is one month.

Adverse reactions

Immune system disorders:
Very rare (<0.01%): allergic reactions, including skin reactions;
Disorders of the gastrointestinal tract:
Unknown frequency (according to the available data it is not possible to estimate the frequency of occurrence): diarrhea, abdominal pain, nausea, vomiting, flatulence.



  • Moderate renal failure (risk of developing hypermagnesia).

Drug interactions


  • With levodopa: Levodopa activity is inhibited by pyridoxine (if the intake of this drug is not combined with the intake of peripheral decarboxylase inhibitors of aromatic L-amino acids). Reception of any amount of pyridoxine should be avoided if levodopa is not taken in combination with the peripheral decarboxylase inhibitors of aromatic L-amino acids.

Combinations not recommended

  • The simultaneous use of drugs containing phosphates or calcium salts, may worsen the absorption of magnesium in the intestine.

Combinations to be taken into account

  • When prescribing inside tetracyclines, it is necessary to observe an interval of at least three hours between ingestion of tetracycline and Magne B6, since magnesium preparations reduce the absorption of tetracyclines.

Special instructions

pills are intended only for adults and children over 6 years.
In moderate renal insufficiency, the drug should be taken with caution because of the risk of hypermagneemia.
If calcium and magnesium are deficient at the same time, magnesium deficiency should be replenished before starting calcium supplements or calcium-containing dietary supplements.
When using pyridoxine in high doses (more than 200 mg per day) for a long time (for several months or in some cases - years), sensory axonal neuropathy may develop, which is accompanied by symptoms such as numbness and impaired proprioceptive sensitivity, distal tremor limbs and gradually developing sensory ataxia (impaired coordination of movements). These disorders are usually reversible and disappear after discontinuation of vitamin B6.
Impact on the ability to drive and engage in other potentially hazardous activities
Does not affect. There are no special recommendations.


With normal kidney function, an overdose of magnesium when taken orally does not usually result in toxic reactions. However, in the case of kidney failure, magnesium poisoning may develop.
Symptoms of overdose, the severity of which depends on the concentration of magnesium in the blood: lower blood pressure; nausea, vomiting; depression of the central nervous system, reduced reflexes; changes on the electrocardiogram; respiratory depression, coma, cardiac arrest and respiratory paralysis; anuric syndrome.
Rehydration, forced diuresis. In renal insufficiency, hemodialysis or peritoneal dialysis is necessary.

Studies and clinical trials of Magnesium, Pyridoxine (Click to expand)

  1. Speciation studies in relation to magnesium bioavailability. Formation of Mg(II) complexes with glutamate, aspartate, glycinate, lactate, pyroglutamate, pyridoxine and citrate, and appraisal of their potential significance towards magnesium gastrointestinal absorption
  2. Brief report: Lack of response in an autistic population to a low dose clinical trial of pyridoxine plus magnesium
  3. Effects of pyridoxine and magnesium on autistic symptoms—Initial observations
  4. High-Dose Pyridoxine and Magnesium Administration in Children with Autistic Disorder: An Absence of Salutary Effects in a Double-Blind, Placebo-Controlled Study
  8. Complex supplementation containing mineral bishofit (MgCl2·6H2O) solution and pyridoxine hydrochloride normalises ethanol-induced magnesium depletion and corrects some behavioural disturbances of animals during chronic alcoholisation
  9. Pyridoxine and magnesium status of women with premenstrual syndrome
  10. Auto-immune complications of D-penicillamine—a possible result of zinc and magnesium depletion and of pyridoxine inactivation.
  11. Growth and development in rats and deficiency of magnesium and pyridoxine.
  12. Effects of Magnesium and High Dietary Intakes of Pyridoxine on the Chick
  13. Mineral Metabolism in Chicks on High Dietary Pyridoxine and Magnesium
  15. Effects of Pyridoxine and Desoxypyridoxine on Magnesium Metabolism in the Rabbit.
  16. ChemInform Abstract: Speciation Studies in Relation to Magnesium Bioavailability. Formation of Mg(II) Complexes with Glutamate, Aspartate, Glycinate, Lactate, Pyroglutamate, Pyridoxine and Citrate, and Appraisal of Their Potential Significance Toward Magn
  17. Treatment of Childhood Asthma with Parenteral Vitamin B12, Gastric Re-acidification, and Attention to Food Allergy, Magnesium and Pyridoxine: Three Case Reports with Background and an Integrated Hypothesis
  18. Studies on the nutritional basis of abnormal behavior in albino rats. V. The effect of pyridoxine deficiency upon sound-induced magnesium tetany.
  19. Effect of Pyridoxine and Magnesium on Stress-Induced Gastric Ulcers in Mice Selected for Low or High Blood Magnesium Levels
  20. Magnesium Oxide-pyridoxine Therapy for Recurrent Calcium Oxalate Calculi
  21. The Influence of Dietary Pyridoxine on Mortality Rate of the Magnesium Deficient Rat

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