Magnesium, Pyridoxine

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Available since: 2019-09-19

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Clinical Pharmacology

Pharmacodynamics
Magnesium is a vital element that is necessary for the normal functioning of cells and is involved in most metabolic reactions. In particular, it is involved in regulating the transmission of nerve impulses and in muscle contraction. 1/3 of the amount of magnesium contained in the body accumulates in the bone tissue. The body gets magnesium with food. Lack of magnesium in the body can be observed in violation of the diet (diet), with an increase in the need for magnesium or imbalance of admission, metabolism and excretion of magnesium (for example, with increased physical and mental stress, stress, during pregnancy, when using diuretics).
Pyridoxine (vitamin B6) is involved in many metabolic processes, improves the absorption of magnesium from the gastrointestinal tract and its penetration into cells.
Serum magnesium levels:
Between 12 and 17 mg / l (1 - 1.4 mEq / l or 0.5 - 0.7 mmol / l): indicate a moderate magnesium deficiency;
Below 12 mg / l (1 mEq / l or 0.5 mmol / l): indicate severe magnesium deficiency.
Pharmacokinetics
Gastrointestinal absorption of magnesium salts occurs partly by a passive mechanism in which the solubility of the salt plays a decisive role. The extent of this absorption does not exceed 50%. Excretion occurs mainly by the kidneys.

Indications

Established magnesium deficiency, isolated or associated with other deficient conditions, accompanied by symptoms such as:

irritability,
minor sleep disturbances
gastrointestinal cramps,
cardiopalmus,
increased fatigue
muscle aches and cramps
tingling sensation in muscles.

If after a month of treatment there is no reduction of these symptoms, the continuation of treatment is inappropriate.

Composition

1 tablet contains

Tablet core:

active ingredients:
- magnesium citrate - 618.43 mg, which corresponds to 100 mg of magnesium (mg ++),
- pyridoxine hydrochloride - 10.00 mg;
Excipients:
- lactose - 50,57 mg,
- macrogol-6000 - 120.00 mg,
- magnesium stearate - 1.00 mg.

Tablet shell:

hypromellose 6 mPa.s - 14.08 mg,
macrogol-6000 - 1.17 mg,
titanium dioxide (E 171) - 4.75 mg,
talc - traces.

Magnesium, Pyridoxine is marketed under different brands and generic names, and comes in different dosage forms:

Brand name	Manufacturer	Country	Dosage form
Magne B6	Sanofi-aventis	France	pills
Magne B6	Sanofi-Aventis	France, France, Hungary	pills
Magnelis B6 Forte	Pharmstandard-Tomsk	Russia	pills
Magnistad	Stada	Germany	pills
Magnelis B6	Pharmstandard Ufavita	Russia	pills
Magnerot	Verwag Pharma	Germany	pills
Magne B6	Sanofi-aventis	France	solution

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Dosage and Administration

pills should be taken whole with a glass of water.
Adults: 3-4 pills per day, divided into 2-3 doses, with meals.
Children over 6 years old (weighing about 20 kg):
10-30 mg / kg / day (0.4–1.2 mmol / kg / day), that is, children over 6 years old (weighing about 20 kg) 2-4 pills per day, divided into 2-3 doses, during food Time.
Usually the duration of treatment is one month.

Adverse reactions

Immune system disorders:
Very rare (<0.01%): allergic reactions, including skin reactions;
Disorders of the gastrointestinal tract:
Unknown frequency (according to the available data it is not possible to estimate the frequency of occurrence): diarrhea, abdominal pain, nausea, vomiting, flatulence.

Contraindications

Carefully

Moderate renal failure (risk of developing hypermagnesia).

Drug interactions

Contraindications

With levodopa: Levodopa activity is inhibited by pyridoxine (if the intake of this drug is not combined with the intake of peripheral decarboxylase inhibitors of aromatic L-amino acids). Reception of any amount of pyridoxine should be avoided if levodopa is not taken in combination with the peripheral decarboxylase inhibitors of aromatic L-amino acids.

Combinations not recommended

The simultaneous use of drugs containing phosphates or calcium salts, may worsen the absorption of magnesium in the intestine.

Combinations to be taken into account

When prescribing inside tetracyclines, it is necessary to observe an interval of at least three hours between ingestion of tetracycline and Magne B6, since magnesium preparations reduce the absorption of tetracyclines.

Special instructions

pills are intended only for adults and children over 6 years.
In moderate renal insufficiency, the drug should be taken with caution because of the risk of hypermagneemia.
If calcium and magnesium are deficient at the same time, magnesium deficiency should be replenished before starting calcium supplements or calcium-containing dietary supplements.
When using pyridoxine in high doses (more than 200 mg per day) for a long time (for several months or in some cases - years), sensory axonal neuropathy may develop, which is accompanied by symptoms such as numbness and impaired proprioceptive sensitivity, distal tremor limbs and gradually developing sensory ataxia (impaired coordination of movements). These disorders are usually reversible and disappear after discontinuation of vitamin B6.
Impact on the ability to drive and engage in other potentially hazardous activities
Does not affect. There are no special recommendations.

Overdosage

Symptoms
With normal kidney function, an overdose of magnesium when taken orally does not usually result in toxic reactions. However, in the case of kidney failure, magnesium poisoning may develop.
Symptoms of overdose, the severity of which depends on the concentration of magnesium in the blood: lower blood pressure; nausea, vomiting; depression of the central nervous system, reduced reflexes; changes on the electrocardiogram; respiratory depression, coma, cardiac arrest and respiratory paralysis; anuric syndrome.
Treatment
Rehydration, forced diuresis. In renal insufficiency, hemodialysis or peritoneal dialysis is necessary.

Studies and clinical trials of Magnesium, Pyridoxine (Click to expand)