Meropenem

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An antibiotic from the carbapenem group for parenteral use. Resistant to dehydropeptidase-1, acts bactericidal (inhibits the synthesis of the bacterial cell wall), easily penetrates the bacterial cell wall, is resistant to the action of most beta-lactamases, has a high affinity for penicillin binding proteins (PBPs).

Among the known beta-lactam antibiotics, it has the highest activity against most aerobic and anaerobic gram-positive and gram-negative microorganisms. Interacts with receptors - specific penicillin-binding proteins on the surface of the cytoplasmic membrane, inhibits the synthesis of the peptidoglycan layer of the cell wall (due to structural similarity), inhibits transpeptidase, promotes the release of autolytic enzymes of the cell wall, which ultimately causes its damage and the death of bacteria.

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