

The hepatoprotective effect of Metadoxinee is due to the membrane stabilizing effect and is based on the ability to restore the ratio of saturated and unsaturated free fatty acids. As a result, hepatocyte resistance to the action of lipid peroxidation, which occurs when exposed to various toxic agents, increases. The detoxification effect of Metadoxinee is due to the activation of liver enzymes involved in the metabolism of ethanol - alcohol dehydrogenase and acetaldehyde dehydrogenase, which accelerates the process of excretion of ethanol and acetaldehyde from the body, and consequently, their toxic effects are reduced.
Metadoxine prevents the accumulation of triglycerides in hepatocytes, and also prevents the formation of fibronectin and collagen, which significantly slows down the process of formation of cirrhosis of the liver.
The drug reduces the mental and somatic manifestations of hangover, reduces the time of relief of withdrawal syndrome.
Metadoxine activates cholinergic and GABAergic neurotransmitter systems, improves the functions of thinking and short memory, prevents the emergence of motor arousal, which is caused by ethanol.
Metadoxine has a nonspecific antidepressant and anxiolytic effect, reduces craving for alcohol.
- Chronic alcoholism.
- Complex therapy of liver diseases, especially of alcoholic etiology.
1 tablet contains: pyridoxine L-2 pyrrolidone 5-carboxylate (Metadoxinee) 500 mg.
Excipients: microcrystalline cellulose, magnesium stearate.
Metadoxine is marketed under different brands and generic names, and comes in different dosage forms:
Brand name | Manufacturer | Country | Dosage form |
---|---|---|---|
Metadoxil® | Baldachi SPA Lab | Italy | pills |
Metadoxil® | Baldachi SPA Lab | Italy | ampoules |
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Combined therapy of liver diseases and chronic alcoholism: 1 tablet 2 times a day (1000 mg) for 15-30 minutes before meals, the dose can be increased to 3 pills (1500 mg) per day. The course of therapy must be at least 90 days.
Allergic reactions. In patients with bronchial asthma, the development of bronchospasm is possible when using the solution for injection.
- Hypersensitivity to the drug.
- Pregnancy.
- Lactation period (breastfeeding).
When applied simultaneously with levodopa, Metadoxinee reduces the effectiveness of the latter.
The use of the drug Metadoxil during pregnancy and lactation (breastfeeding) is not recommended.
With caution should be prescribed the drug in Parkinson's disease, if levodopa is used simultaneously, because Metadoxinee reduces the effectiveness of the latter.
Currently, cases of overdose Metadoxil were reported.
Studies and clinical trials of Metadoxine (Click to expand)