Metadoxil® [Metadoxine]
Baldachi SPA Lab
852 Items
2019-09-19
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Clinical Pharmacology
The hepatoprotective effect of Metadoxinee is due to the membrane stabilizing effect and is based on the ability to restore the ratio of saturated and unsaturated free fatty acids. As a result, hepatocyte resistance to the action of lipid peroxidation, which occurs when exposed to various toxic agents, increases. The detoxification effect of Metadoxinee is due to the activation of liver enzymes involved in the metabolism of ethanol - alcohol dehydrogenase and acetaldehyde dehydrogenase, which accelerates the process of excretion of ethanol and acetaldehyde from the body, and consequently, their toxic effects are reduced.
Metadoxine prevents the accumulation of triglycerides in hepatocytes, and also prevents the formation of fibronectin and collagen, which significantly slows down the process of formation of cirrhosis of the liver.
The drug reduces the mental and somatic manifestations of hangover, reduces the time of relief of withdrawal syndrome.
Metadoxine activates cholinergic and GABAergic neurotransmitter systems, improves the functions of thinking and short memory, prevents the emergence of motor arousal, which is caused by ethanol.
Metadoxine has a nonspecific antidepressant and anxiolytic effect, reduces craving for alcohol.
Indications
- Chronic alcoholism.
- Complex therapy of liver diseases, especially of alcoholic etiology.
Composition
1 tablet contains: pyridoxine L-2 pyrrolidone 5-carboxylate (Metadoxinee) 500 mg.
Excipients: microcrystalline cellulose, magnesium stearate.
Metadoxine is marketed under different brands and generic names, and comes in different dosage forms:
| Brand name | Manufacturer | Country | Dosage form |
|---|---|---|---|
| Metadoxil® | Baldachi SPA Lab | Italy | pills |
| Metadoxil® | Baldachi SPA Lab | Italy | ampoules |
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Dosage and Administration
Combined therapy of liver diseases and chronic alcoholism: 1 tablet 2 times a day (1000 mg) for 15-30 minutes before meals, the dose can be increased to 3 pills (1500 mg) per day. The course of therapy must be at least 90 days.
Adverse reactions
Allergic reactions. In patients with bronchial asthma, the development of bronchospasm is possible when using the solution for injection.
Contraindications
- Hypersensitivity to the drug.
- Pregnancy.
- Lactation period (breastfeeding).
Drug interactions
When applied simultaneously with levodopa, Metadoxinee reduces the effectiveness of the latter.
Pregnancy and Lactation
The use of the drug Metadoxil during pregnancy and lactation (breastfeeding) is not recommended.
Special instructions
With caution should be prescribed the drug in Parkinson's disease, if levodopa is used simultaneously, because Metadoxinee reduces the effectiveness of the latter.
Overdosage
Currently, cases of overdose Metadoxil were reported.
- Brand name: Metadoxil
- Active ingredient: Metadoxine
Studies and clinical trials of Metadoxine (Click to expand)
- Preliminary findings on the use of metadoxine for the treatment of alcohol dependence and alcoholic liver disease
- A follow up study on the efficacy of metadoxine in the treatment of alcohol dependence
- Negligible effect of oral garlic oil on the oral absorption of pyridoxine in metadoxine in rats
- Metadoxine in Acute Alcohol Intoxication: A Double-Blind, Randomized, Placebo-Controlled Study
- Stability-Indicating HPLC Method for the Determination of Metadoxine as Bulk Drug and in Pharmaceutical Dosage Form
- The beneficial effect of metadoxine (pyridoxine-pyrrolidone-carboxylate) in the treatment of fatty liver diseases
- Combined metadoxine and garlic oil treatment efficaciously abrogates alcoholic steatosis and CYP2E1 induction in rat liver with restoration of AMPK activity
- Application of stability-indicating HPTLC method for quantitative determination of metadoxine in pharmaceutical dosage form
- Metadoxine, an ion-pair of pyridoxine and l-2-pyrrolidone-5-carboxylate, blocks adipocyte differentiation in association with inhibition of the PKA-CREB pathway
- Metadoxine partially prevents fibrosis and completely preserves glycogen stores in prolonged biliary obstruction in the rat: A comparison with colchicine
- Metadoxine accelerates fatty liver recovery in alcoholic patients: results of a randomized double-blind, placebo-control trial
- Treatment of alcoholic fatty liver: is the metabolic effect of metadoxine the only reason for improved liver function?
- P.1.c.055 Metadoxine:a novel 5HT-2B receptor antagonist with a possible therapeutic role in treating ADHD
- S.26.03 Metadoxine: a novel non-stimulant extended-release drug for treating ADHD
- Metadoxine prevents damage produced by ethanol and acetaldehyde in hepatocyte and hepatic stellate cells in culture
- Metadoxine Versus Placebo for the Treatment of Non-alcoholic Steatohepatitis: A Randomized Controlled Trial
- P302 METADOXINE SIGNIFICANTLY IMPROVES SURVIVAL IN ABIC CLASS B PATIENTS WITH SEVERE ALCOHOLIC HEPATITIS WHEN ADDED TO PENTOXIFYLLINE OR PREDNISONE
- Efficacy of Metadoxine in the Management of Acute Alcohol Intoxication
- Efficacy of Metadoxine Extended Release in Patients With Predominantly Inattentive Subtype Attention-Deficit/Hyperactivity Disorder
- Attention Benefits after a Single Dose of Metadoxine Extended Release in Adults with Predominantly Inattentive ADHD
- A Randomized, Double-Blind, Placebo-Controlled, Multicenter Study Evaluating the Efficacy, Safety, and Tolerability of Extended-Release Metadoxine in Adults With Attention-Deficit/Hyperactivity Disorder
- METADOXINE (PYRROLIDONE CARBOXYLATE OF PYRIDOXINE) ANTAGONIZES THE LOCOMOTOR-STIMULATORY EFFECT OF ETHANOL IN MICE
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