Methionine
Pharmstandard Ufavita
1808 Items
2019-09-19
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Clinical Pharmacology
METIONIN is an essential amino acid necessary to maintain the growth and nitrogen balance of the body. It contains a methyl group that is involved in the process of peremetilirovaniya and is necessary for the synthesis of choline. Due to this, it normalizes the synthesis of phospholipids from fats and reduces the deposition of neutral fat in the liver.
Participates in the exchange of sulfur-containing amino acids, in the synthesis of epinephrine, creatinine and other biologically active substances, activates the action of hormones, vitamins (B12, ascorbic, folic acid), enzymes, proteins, peremetilirovaniya, deamination, decarboxylation reactions. Required for detoxification of xenobiotics.
When atherosclerosis reduces the concentration of cholesterol and increases the concentration of blood phospholipids.
Indications
Liver diseases proceeding with fatty infiltration of hepatocytes: toxic hepatitis, hepatosis (including alcoholic), cirrhosis, liver dystrophy; intoxication.
Prevention of toxic liver damage with arsenic, chloroform, benzene, alcohol.
As part of combination therapy: protein deficiency of various origins, atherosclerosis, diabetes.
Composition
active substance: methionine 0.25 g
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Dosage and Administration
Adults - 500 mg-1.5 g 3-4 times / day.
Single doses for children under the age of 1 year - 100 mg, at the age of 1-2 years - 200 mg, at the age of 3-4 years - 250 mg, at the age of 5-6 years - 300 mg, at the age of over 7 years - 500 mg; the multiplicity of reception - 3-4 times / day.
Take 1 / 2-1 h before meals. The course of treatment is 10-30 days or 10 days with 10-day breaks.
Adverse reactions
Nausea, vomiting.
Contraindications
Hypersensitivity to methionine, severe liver failure, hepatic encephalopathy, viral hepatitis.
Drug interactions
With simultaneous use with levodopa its effectiveness decreases.
Special instructions
It is used with caution in case of renal failure (danger of increasing hyperazotemia).
When methionine was used in patients with atherosclerosis, a decrease in blood cholesterol levels and an increase in phospholipid levels was observed.
It should be prescribed in balance with other amino acids. Unbalanced use of methionine in large doses can have a damaging effect on the cells of the liver and other organs.
- Brand name: Methionine
- Active ingredient: Methionine
- Dosage form: Pills
- Manufacturer: Pharmstandard Ufavita
- Country of Origin: Russia
Studies and clinical trials of Methionine (Click to expand)
- Functional methionine synthase deficiency due to cblG disorder: A report of two patients and a review
- Genetic polymorphisms in methylenetetrahydrofolate reductase and methionine synthase, folate levels in red blood cells, and risk of neural tube defects
- Methionine enkephalin immunoreactivity in the brain of the budgerigar (Melopsittacus undulatus): Similarities and differences with respect to oscine songbirds
- Identification of a MS-MS Fragment Diagnostic for Methionine Sulfoxide
- Is dietary intake of methionine associated with a reduction in risk for neural tube defect-affected pregnancies?
- Effects of methionine supplement on methionine incorporation in rat embryos cultured in vitro
- Effects of supplemental methionine on antiserum-induced dysmorphology in rat embryos cultured in vitro
- Changes in available methionine and tryptophan contents during cereal flake production
- Disruption of six novelSaccharomyces cerevisiae genes reveals thatYGL129c is necessary for growth in non-fermentable carbon sources,YGL128c for growth at low or high temperatures andYGL125w is implicated in the biosynthesis of methionine
- Structural characterization of a methionine-rich, emulsifying protein from sunflower seed
- Inhibition of methionine uptake by CIS-diamminedichloroplatinum (II) in experimental brain tumors
- Response of the methionine synthase system to short-term culture with homocysteine and nitrous oxide and its relation to methionine dependence
- Identification of Oxidized Methionine in Peptides
- The b1 ion derived from methionine is a stable species
- The metastable decomposition of a peptide containing oxidized methionine(s) in matrix-assisted laser desorption/ionization time-of-flight mass spectrometry
- Synthesis, conformation, and biological activity of two fMLP-OMe analogues containing the new 2-[2′-(methylthio) ethyl] methionine residue
- Methionine ligation strategy in the biomimetic synthesis of parathyroid hormones
- Flow cytometric analysis of peroxidative activity in granulocytes from coronary and peripheral blood in acute myocardial ischemia and reperfusion in dogs: Protective effect of methionine
- Radical polymerization of acrylamide initiated by ceric ammonium nitrate-methionine redox initiator system
- Selective inhibition of endothelial cell proliferation by fumagillin is not due to differential expression of methionine aminopeptidases
- Methionine synthase D919G polymorphism is a significant but modest determinant of circulating homocysteine concentrations
- Heat capacity and phonon dispersion in poly(L-methionine)
- Determination of the deprotonation constants of seleno-DL-cystine and seleno-DL-methionine and implication to their separation by HPLC
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