Buy Metoclopramide pills 10 mg, 50 pcs
  • Buy Metoclopramide pills 10 mg, 50 pcs

Metoclopramide

Polpharma
587 Items
2019-09-19
Dosage form
Brand & Manufacturer
Package Size
$20.25
Quantity
  • done All payments are SSL encrypted
  • done Full Refund if you haven't received your order
  • done International shipping to the USA, UK and Europe

Clinical Pharmacology

Metoclopramide - an antiemetic, helps reduce nausea, hiccups; stimulates gastrointestinal peristalsis. An antiemetic effect due to blockade of dopamine D2 receptors and an increase in the threshold of chemoreceptors of the trigger zone, is a blocker of serotonin receptors. Metoclopramide is believed to inhibit the relaxation of gastric smooth muscle caused by dopamine, thus enhancing the cholinergic reactions of the gastrointestinal smooth muscle. It contributes to the acceleration of gastric emptying by preventing the relaxation of the body of the stomach and increasing the activity of the antrum of the stomach and upper sections of the small intestine. It reduces the reflux of the contents into the esophagus by increasing the pressure of the esophageal sphincter at rest and increases the clearance of acid from the esophagus due to an increase in the amplitude of its peristaltic contractions.

Metoclopramide stimulates the secretion of prolactin and causes a transient increase in the level of circulating aldosterone, which may be accompanied by short-term fluid retention.

Indications

  • vomiting, nausea, hiccups of various origins (in some cases, it can be effective with vomiting caused by radiation therapy or cytotoxic drugs);
  • atony and hypotonia of the stomach and intestines (in particular, postoperative);
  • biliary dyskinesia on hypomotor type;
  • reflux esophagitis;
  • flatulence;
  • functional pyloric stenosis; .
  • as part of the treatment of acute gastric and duodenal ulcers;
  • used to enhance peristalsis when conducting radiopaque studies of the gastrointestinal tract;
  • as a means of facilitating duodenal intubation (to accelerate gastric emptying and the movement of food through the small intestine).

Composition

1 tablet contains:

Active substance: metoclopramide hydrochloride 10 mg;

Excipients: lactose; corn starch; purified talc; magnesium stearate; sodium starch glycolate; colloidal anhydrous silicon.

Metoclopramide is marketed under different brands and generic names, and comes in different dosage forms:

Brand nameManufacturerCountryDosage form
Metoclopramide Polpharma Poland pills
Metoclopramide Sotex Russia solution
Metoclopramide PFK Obnovlenie Russia pills
Metoclopramide Novosibkhimpharm Russia ampoules
Cerucal® Teva Israel pills
Cerucal® Teva Israel solution

No customer reviews for the moment.

Write your review

Write your review

Metoclopramide

Dosage and Administration

pills are taken 30 minutes before a meal, washed down with a small amount of water.For adults- 5–10 mg 3-4 times a day. The maximum single dose - 20 mg daily - 60 mg.Children over 6 years old - 5 mg 1-3 times a day.

Adverse reactions

From the digestive system: at the beginning of treatment, constipation, diarrhea; rarely, dry mouth.

From the side of the central nervous system: At the beginning of the treatment, fatigue, drowsiness, dizziness, headache, depression, akathisia are possible. Extrapyramidal symptoms may occur in children and young people (even after a single use of metoclopramide): spasm of the facial muscles, hyperkinesis, spastic torticollis (as a rule, they disappear immediately after stopping metoclopramide). With prolonged use, more often in elderly patients, parkinsonism and dyskinesia are possible.

From the hemopoietic system: at the beginning of treatment, agranulocytosis is possible.

On the part of the endocrine system: rarely, with prolonged use in high doses - galactorrhea, gynecomastia, menstrual disorders.

Allergic reactions: rarely a skin rash.

Not prescribed after operations on the digestive tract (such as pyloroplasty or intestinal anastomosis), because vigorous muscle contractions prevent healing.

If you have hypersensitivity to metoclopramide or other components of the drug, be sure to consult your doctor before taking it.

Carefully:bronchial asthma, arterial hypertension, Parkinson's disease, renal and / or liver failure, old age (over 65), children's age (increased risk of developing dyskinetic syndrome).

Drug interactions

With simultaneous use with anticholinergic agents, mutual weakening of effects is possible.

With simultaneous use with neuroleptics (especially the phenothiazine series and butyrophenone derivatives), the risk of extrapyramidal reactions increases.

With simultaneous use increases the absorption of acetylsalicylic acid, paracetamol, ethanol.

Metoclopramide with a / in the introduction increases the rate of absorption of diazepam and increases its maximum concentration in the blood plasma.

With simultaneous use with a slowly dissolving digoxin dosage form, it is possible to reduce the serum digoxin concentration by 1/3. With simultaneous use with digoxin in a liquid dosage form or in the form of an instant dosage form, the interaction was not observed.

With simultaneous use with zopiclone, the absorption of picoplone is accelerated; with cabergoline - may decrease the effectiveness of cabergoline; with ketoprofen - decreases the bioavailability of ketoprofen.

Due to the antagonism of dopamine receptors, metoclopramide may reduce the anti-Parkinsonian effect of levodopa, and the bioavailability of levodopa may increase due to the acceleration of its evacuation from the stomach under the influence of metoclopramide. The results of the interaction are ambiguous.

At simultaneous use with meksiletinom absorption of meksiletin accelerates; with mefloquine - the rate of absorption of mefloquine and its concentration in the blood plasma increases, while its side effects can be reduced.

With simultaneous use with morphine, morphine absorption is accelerated when taken orally and its sedative effect increases.

With simultaneous use with nitrofurantoin, the absorption of nitrofurantoin decreases.

When using metoclopramide immediately before the administration of propofol or thiopental, it may be necessary to reduce their induction doses.

In patients receiving metoclopramide, the effects of suxametonium chloride are enhanced and prolonged.

With simultaneous use with tolterodine, the effectiveness of metoclopramide decreases; with fluvoxamine - described the case of the development of extrapyramidal disorders; with fluoxetine - there is a risk of extrapyramidal disorders; with cyclosporine - the absorption of cyclosporine increases and its concentration in blood plasma increases.

Pregnancy and Lactation

Contraindicated for use in pregnancy.

When used during lactation (breastfeeding), it should be borne in mind that metoclopramide penetrates into breast milk.

In experimental studies, the adverse effect of metoclopramide on the fetus has not been established.

Special instructions

It is used with caution in patients with bronchial asthma, arterial hypertension, impaired liver and / or kidney function, in Parkinson's disease.

With extreme caution should be used in children, especially young children, because they have a significantly higher risk of dyskinetic syndrome. Metoclopramide in some cases can be effective with vomiting caused by cytotoxic drugs.

When used in elderly patients, it must be borne in mind that with prolonged use of metoclopramide in high or medium doses, the most frequent side effects are extrapyramidal disorders, especially parkinsonism and tardive dyskinesia.

Against the background of the use of metoclopramide, data may be distorted by laboratory values ​​of liver function and determine the concentration of aldosterone and prolactin in the blood plasma.

Influence on ability to drive motor transport and control mechanisms

During treatment, you should avoid potentially hazardous activities that require increased attention, quick psychomotor reactions.

Overdosage

Hypersomnia, disorientation, and extrapyramidal disorders may occur. As a rule, the symptoms disappear after discontinuation of the drug in 24 hours. If necessary, treatment with anticholinergics and anti-Parkinsonian agents.

  • Brand name: Metoclopramide
  • Active ingredient: Metoclopramide
  • Dosage form: Pills
  • Manufacturer: Polpharma
  • Country of Origin: Poland

Studies and clinical trials of Metoclopramide (Click to expand)

  1. Comparison of the efficacy and safety of tropisetron, metoclopramide, and chlorpromazine in the treatment of emesis associated with far advanced cancer
  2. Improved control of cisplatin-induced emesis with high-dose metoclopramide and with combinations of metoclopramide, dexamethasone, and diphenhydramine. Results of consecutive trials in 255 patients
  3. The antiemetic efficacy of secobarbital and chlorpromazine compared to metoclopramide, diphenhydramine, and dexamethasone: A randomized trial
  4. Antiemetic control and prevention of side effects of anti-cancer therapy with lorazepam or diphenhydramine when used in combination with metoclopramide plus dexamethasone. A double-blind, randomized trial
  5. High-dose versus low-dose metoclopramide in the prevention of cisplatin-induced emesis. A randomized crossover study in patients with ovarian carcinoma
  6. A prospective, randomized double-blind trial comparing metoclopramide alone with metoclopramide plus dexamethasone in preventing emesis induced by high-dose cisplatin
  7. Metoclopramide versus metoclopramide and lorazepam. Superiority of combined therapy in the control of cisplatin-induced emesis
  8. A randomized, double-blind comparison of the antiemetic effect of metoclopramide and lorazepam with or without dexamethasone in patients receiving high-dose cisplatin
  9. Phase III double-blind comparison of intravenous ondansetron and metoclopramide as antiemetic therapy for patients receiving multiple-day cisplatin-based chemotherapy
  10. Comparison of intermittent ondansetron versus continuous infusion metoclopramide used with standard combination antiemetics in control of acute nausea induced by cisplatin chemotherapy
  11. A randomized, multicenter study comparing the efficacy and tolerability of tropisetron, a new 5-HT3 receptor antagonist, with a metoclopramide-containing antiemetic cocktail in the prevention of cisplatin-induced emesis
  12. The addition of ondansetron to the combination of metoclopramide, dexamethasone, and lorazepam did not improve vomiting prevention in patients receiving high-dose cisplatin
  13. Comparison of the efficacy, safety, and pharmacokinetics of controlled release and immediate release metoclopramide for the management of chronic nausea in patients with advanced cancer
  14. Oral granisetron with or without methylprednisolone versus metoclopramide plus methylprednisolone in the management of delayed nausea and vomiting induced by cisplatin-based chemotherapy. A prospective randomized trial
  15. Randomized, double-blind comparison of a prochlorperazine-based versus a metoclopramide-based antiemetic regimen in patients undergoing autologous bone marrow transplantation
  16. Successful treatment of Diamond-Blackfan anemia with metoclopramide
  17. Chronic dysarthria and metoclopramide
  18. New Findings in the Synthesis of Metoclopramide
  19. Availability of Metoclopramide in vitro and in vivo
  20. Preparation and In Vitro Pharmacology of 5-HT4 Receptor Ligands. Partial Agonism and Antagonism of Metoclopramide Analogous Benzoic Esters
  21. Stimulatory effect of metoclopramide on the esophagus and lower esophageal sphincter of patients with pss
  22. The effect of antacid, metoclopramide, and propantheline on the bioavailability of metoprolol and atenolol
  23. Bioavailability studies with ciglitazone in beagles II. Effect of propantheline bromide and metoclopramide HCL on bioavailability of a tablet

8 other products in the same category:

arrow_upward