Micozone® [Miconazole]
Agio Pharmaceuticals Ltd
1244 Items
2019-09-19
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Clinical Pharmacology
Mykozon - has antifungal effects. It inhibits the synthesis of ergosterol, changes the lipid composition and permeability of the cell wall. Active against dermatophytes yeast and other fungi. Shows antimicrobial activity against gram-positive microorganisms.
Pharmacokinetics
With local applications in the blood is found only a small number of metabolites. It is rapidly destroyed in the liver, excreted through the kidneys, 14-22% of the dose in the form of inactive derivatives.
Indications
Fungal (trichophytosis and athlete's hands, feet and torso, cutaneous candidiasis, pityriasis versicolor, etc.) And mixed fungal-bacterial skin lesions and nail candidiasis of the gastrointestinal tract, oropharyngeal candidiasis and its prevention in the treatment of inhaled glucocorticoids, vulvovaginal candidiasis and infections caused by Gram-positive microbes.
Composition
1 g contains:
Active substance: omoconazole nitrate 20 mg;
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Dosage and Administration
The cream is applied 2 times a day on the affected surface with soft rubbing movements. Treatment continues until the symptoms disappear and over the next few days to prevent recurrence.
Adverse reactions
Local skin reactions (burning, stinging, redness), irritation of the mucous membrane of the vagina, pain in the lower abdomen, allergic contact dermatitis.
Contraindications
Hypersensitivity, pregnancy (II-III trimesters - for the use of vaginal forms), hepatic and / or renal failure, children under 12 years old (for vaginal forms) .C caution. Diabetes, microcirculation disorders.
Drug interactions
Enhances the effect of indirect anticoagulants, oral hypoglycemic drugs, phenytoin.
Special instructions
It is necessary to conduct simultaneous treatment of both sexual partners. During pregnancy, vaginal use of the drug (vaginal suppositories, capsules) is possible only in the first trimester. When applied topically, the cream is not absorbed and can be used during pregnancy and lactation. Do not allow the drug in the eyes. If the nails are damaged, they should be cut as short as possible. With the defeat of the feet, the interdigital spaces are carefully treated.
- Brand name: Micozone®
- Active ingredient: Miconazole
- Dosage form: Cream for external use of 2%
- Manufacturer: Agio Pharmaceuticals Ltd
- Country of Origin: India
Studies and clinical trials of Miconazole (Click to expand)
- Chemopreventive efficacy of anethole trithione, N-acetyl-L-cysteine, miconazole and phenethylisothiocyanate in the DMBA-induced rat mammary cancer model
- Miconazole genotoxicity in mice
- Depression by miconazole of heat-induced respiratory-deficiency in Saccharomyces cerevisiae
- The Crystal Structure of 1-{2,4-Dichloro-β- [(2,4-Dichloro-Benzyl)Oxy] Phenethyl} Imidazole Hemihydrate: Miconazole. 1/2 H2O
- New Highly Asymmetric Henry Reaction Catalyzed by CuII and a C1-Symmetric Aminopyridine Ligand, and Its Application to the Synthesis of Miconazole
- ChemInform Abstract: Funicone-Related Compounds, Potentiators of Antifungal Miconazole Activity, Produced by Talaromyces flavus FKI-0076.
- New Beauvericins, Potentiators of Antifungal Miconazole Activity, Produced by Beauveria sp. FKI-1366. Part 2. Structure Elucidation.
- New Beauvericins, Potentiators of Antifungal Miconazole Activity, Produced by Beauveria sp. FKI-1366. Part 1. Taxonomy, Fermentation, Isolation and Biological Properties.
- Phenatic Acids A and B, New Potentiators of Antifungal Miconazole Activity Produced by Streptomyces sp. K03-0132.
- Citridones, New Potentiators of Antifungal Miconazole Activity, Produced by Penicillium sp. FKI-1938. Part 2. Structure Elucidation.
- Citridones, New Potentiators of Antifungal Miconazole Activity, Produced by Penicillium sp. FKI-1938. Part 1. Taxonomy, Fermentation, Isolation and Biological Properties.
- Tensidols, New Potentiators of Antifungal Miconazole Activity, Produced by Aspergillus niger FKI-2342.
- ChemInform Abstract: New Highly Asymmetric Henry Reaction Catalyzed by CuII and a C1-Symmetric Aminopyridine Ligand, and Its Application to the Synthesis of Miconazole.
- ChemInform Abstract: Citrinamides, New Potentiators of Antifungal Miconazole Activity, Produced by Penicillium sp. FKI-1938.
- ChemInform Abstract: 6′-Hydroxy-3′-methoxy-mitorubrin (I), a New Potentiator of Antifungal Miconazole Activity, Produced by Penicillium radicum FKI-3765-2.
- Determination of the absolute configuration and solution conformation of the antifungal agents ketoconazole, itraconazole, and miconazole with vibrational circular dichroism
- Comparison of the efficacy and safety of miconazole 50-mg mucoadhesive buccal tablets with miconazole 500-mg gel in the treatment of oropharyngeal candidiasis : A prospective, randomized, single-blind, multicenter, comparative, phase III trial in patients treated with radiotherapy for head and neck cancer
- A three-day study with miconazole gelatin capsules in vaginal candidosis
- Structure and generation mechanism of a novel degradation product formed by oxidatively induced coupling of miconazole nitrate with butylated hydroxytoluene in a topical ointment studied by HPLC-ESI-MS and organic synthesis
- Comparative study between the polysaccharide-based Chiralcel OJ and Chiralcel OD CSPs in chromatographic enantioseparation of imidazole analogues of Fluoxetine and Miconazole
- Miconazole: an inhibitor of cyanide-insensitive respiration in Trypanosoma brucei
- A solid phase synthesis of miconazole analogs via an iodoetherification reaction
- Acute pyogenic Pseudallescheria boydii foot infection sequentially treated with miconazole and itraconazole
- Suppression of delayed-type hypersensitivity in tumour-bearing mice by treatment with miconazole
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