Minoxidil
Minoxidil is a topical use remedy for hair loss (androgenic alopecia) developed in 1963. It is used in both male and femaile. Minoxidil works by improving blood flow to the follicles, thus supplying more oxygen and nutrients essential for hair growth. The drug is marketed under multiple brand names, the most well-known of which is Rogaine
Aerosol Service AG
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2019-09-19
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Clinical Pharmacology
The drug for the treatment of baldness. It has a stimulating effect on hair growth in men and women with androgenetic alopecia (male-type baldness). The appearance of signs of hair growth is noted after 4 months or more of the drug use 2 times / day. The onset and severity of the effect may vary in different patients. After the drug is discontinued, the growth of new hair stops, and after 3-4 months it is possible to restore the original appearance.
The active ingredient of the drug - minoxidil - with systemic use has a vasodilating effect. In controlled clinical trials after external use of Rogaine®, patients with both normal and elevated blood pressure did not show systemic side effects associated with systemic absorption of minoxidil.
Indications
- androgenetic alopecia in men and women (in order to restore hair or stabilize the process of hair loss).
Composition
1 ml of solution contains minoxidil 50 mg.
Minoxidil is marketed under different brands and generic names, and comes in different dosage forms:
| Brand name | Manufacturer | Country | Dosage form |
|---|---|---|---|
| Rogaine® | Aerosol Service AG | Italy | Other |
| Generolon | Belupo | Croatia | spray |
| Kosilon | Bosnalek | Bosnia and Herzegovina | solution |
| Kosilon | Bosnalek | Bosnia and Herzegovina | spray |
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Dosage and Administration
The drug is intended only for external use on the skin of the scalp. Do not apply the drug Regeyn on the skin of other parts of the body.
Rogaine® is applied to the skin of the scalp in a dose of 1 ml 2 times / day. (in the morning and in the evening), starting from the center of the affected area and around the affected area with the help of special applicators. The drug is used in such a dose, regardless of the size of the affected skin. The total daily dose should not exceed 2 ml.
Different applicators are used depending on the length of the hair and the size of the balding area. The drug should be applied to thoroughly dried skin and hair.
In order to dose of the drug was 1 ml, you should press the pump of the applicator, directed to the center of the affected area, 6 times. Wash hands thoroughly after application.
To maintain a stable effect, the constant use of the drug is recommended. One bottle of the drug is designed for use within 30 days.
Adverse reactions
Dermatological reactions: often - redness, itching, flaking of the scalp; in some cases, hypertrichosis (unwanted growth of body hair, including the growth of facial hair in women).
The use of the drug can cause increased hair loss during the transition from the resting phase to the phase of hair growth (this is a temporary phenomenon observed after 2-6 weeks after the start of therapy and gradually, within 2 weeks, stops).
Contraindications
Since the cardiovascular system: in some cases - arterial hypotension.
The drug is well tolerated. In clinical studies in patients with normal or elevated blood pressure, Regeyn's topical administration was not accompanied by systemic side effects.
- children's and teenage age up to 18 years;
- Hypersensitivity to Minoxidil and other components of the drug.
The drug should not be applied with redness, inflammation, infection, pain in the scalp (including with sunburn).
Drug interactions
When applied simultaneously to the skin of Rogaine® and topical preparations containing tretinoin, anthralin / dithranol (which cause a change in the protective function of the skin), may increase the absorption of minoxidil.
Pregnancy and Lactation
Rogaine® should not be used during pregnancy and lactation.
Special instructions
In addition to hereditary predisposition, hair loss can be caused by other causes. Regene does not prevent hair loss caused by certain drugs, malnutrition (iron or vitamin A deficiency in the body), as well as hair loss due to styling in tight hair.
The patient should be warned about the need to consult with a doctor in cases where hair loss began suddenly, baldness is focal in nature and the patient has a pathology of the cardiovascular system.
If systemic side effects appear (chest pains, palpitations, dizziness, decrease in blood pressure, sudden increase in body weight, swelling of hands and / or legs), as well as redness and irritation at the site of rubbing, the drug should be canceled and, if necessary, appropriate therapy should be given.
In case of contact with the eyes, damaged skin or mucous membranes, immediately rinse the affected area with plenty of running cold water. Inhalation of the drug should be avoided when spraying.
Some patients after the use of the drug was observed to change the color and structure of the hair.
It is necessary to avoid flushing the drug, the hair can be wet no earlier than 4 hours after the use of Regine.
In the period of use of Regain, you can use hair care products (including hair spray). In this case, you should first apply the drug and allow the treated area of skin to dry completely, and then apply care products.
According to currently available hair dyeing, performing a perm or using conditioners does not reduce the effectiveness of Rogaine®, provided that the preparation is completely washed off the hair and scalp before performing these procedures.
Overdosage
If you follow the recommended method of administration and dosing regimen, overdose is unlikely.
In case of accidental ingestion of the drug should take into account that 5 ml of 2% and 2 ml of 5% of Regeyn contain 100 mg of Minoxidil - the maximum recommended dose for adults in the treatment of hypertension.
Symptoms: possible development of systemic side effects associated with the vasodilating properties of Minoxidil (decrease in blood pressure, tachycardia, dizziness, weight gain, fainting).
Treatment: the patient should be warned that in these cases it is necessary to urgently consult a doctor.
- Brand name: Rogaine®
- Active ingredient: Minoxidil
- Dosage form: Solution for external use.
- Manufacturer: Aerosol Service AG
- Country of Origin: Italy
Studies and clinical trials of Minoxidil (Click to expand)
- Pharmacokinetics of minoxidil in patients with cirrhosis and healthy volunteers
- The effect of UVB-induced erythema on the percutaneous absorption of minoxidil from an aqueous topical solution
- Topically applied minoxidil may cause fetal malformation: A case report
- Synthesis of 2,4-diamino-6-piperidinylpvrimidine-3-oxide-3′,4′,;5′-3h(n) tritiated minoxidil
- Crystal structure of minoxidil at low temperature and polymorph prediction
- Relative uptake of minoxidil into appendages and stratum corneum and permeation through human skin in vitro
- Metabolism of minoxidil, a new hypotensive agent I: Absorption, distribution, and excretion following administration to rats, dogs, and monkeys
- Metabolism of minoxidil, a new hypotensive agent II: Biotransformation following oral administration to rats, dogs, and monkeys
- Radioimmunoassay of minoxidil in human serum
- Determination of minoxidil in bulk drug and pharmaceutical formulations by ion-pairing high-performance liquid chromatography
- Relationship between contact time of applied dose and percutaneous absorption of minoxidil from a topical solution
- Drug and vehicle deposition from topical applications: Use of in vitro mass balance technique with minoxidil solutions
- Relative influence of ethanol and propylene glycol cosolvents on deposition of minoxidil into the skin
- Penetration of minoxidil from ethanol/propylene glycol solutions: Effect of application volume and occlusion
- A simple spectrophotometric method for the determination of minoxidil
- Divergent effects of propranolol and furosemide pretreatment on acute cardiomyopathy induced by minoxidil in beagle dogs
- Age dependence of the cardiac lesions induced by minoxidil in the rat
- Simultaneous effects of tocopheryl polyethylene glycol succinate (TPGS) on local hair growth promotion and systemic absorption of topically applied minoxidil in a mouse model
- Formulation and in vitro assessment of minoxidil niosomes for enhanced skin delivery
- Penetration enhancer-containing vesicles (PEVs) as carriers for cutaneous delivery of minoxidil
- The effects of particle properties on nanoparticle drug retention and release in dynamic minoxidil foams
- Near ultraviolet spectroscopic studies of 2,4-diamino-6-piperidinopyrimidine-3-oxide (minoxidil) and 2,4-diamino-6-piperidinopyrimidine (desoxyminoxidil)
- The determination of minoxidil in human serum by high-performance liquid chromatography with amperometric detection
- Rapid determination of minoxidil in human plasma using ion-pair HPLC
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Minoxidil is a topical use remedy for hair loss (androgenic alopecia) developed in 1963. It is used in both male and femaile. Minoxidil works by improving blood flow to the follicles, thus supplying more oxygen and nutrients essential for hair growth. The drug is marketed under multiple brand names, the most well-known of which is Rogaine
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