Miramistin
Infamed
1696 Items
2019-09-19
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Clinical Pharmacology
Miramistin is an antiseptic drug. The mechanism of action is associated with the hydrophobic interaction of the drug with the cytoplasmic membranes of microorganisms, which leads to their destruction. Bactericidal effect. Miramistin is active against gram-positive and gram-negative, aerobic and anaerobic, spore-forming and asporogenic bacteria in the form of monocultures and microbial associations, including hospital strains with multi-resistance to antibiotics. Gram-positive microorganisms (Staphylococcus spp., Streptococcus spp., Bac. Anthracoides, Bac. Subtilis) have the highest sensitivity to the drug; mushrooms (Candida albicans, Candida tropicalis, Trichophyton rubrum, Microsporum lanosum, Aspergillus niger); Gram-negative microorganisms: Neisseria spp., Eschrichia spp., Shigella spp. (including Sonne, Flexner), Salmonella spp. (typhoid, paratyphoid A and B, causative agents of food toxicoinfections), Vibrio spp. (including cholera, NAG, paracholeric, para hemolytic), Treponema pallidum, Corynebacterium diphtheriae; protozoa (Chlamidium trachomatis, Chlamidium pneumonia). Miramistin also has an antiviral effect.
Indications
- prevention of suppuration and treatment of purulent wounds in surgical and obstetric practice;
- superficial and deep burns;
- inflammatory diseases of the female genital sphere;
- individual prevention of sexually transmitted diseases (syphilis, gonorrhea, trichomoniasis, chlamydia, genital herpes, genital candidiasis);
- acute and chronic urethritis and urethroprostatitis of a specific and non-specific nature;
- periodontitis, stomatitis, hygienic processing of removable dentures;
- acute and chronic otitis media, sinusitis, tonsillitis, laryngitis (as part of complex therapy).
Composition
1 ml of solution contains Miramistina 0.1 mg
Miramistin is marketed under different brands and generic names, and comes in different dosage forms:
| Brand name | Manufacturer | Country | Dosage form |
|---|---|---|---|
| Miramistin | Infamed | Russia | vials |
| Miramistin | Infamed | Russia | solution |
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Dosage and Administration
In the treatment of purulent wounds and burns prescribed imposition of gauze dressings moistened with a solution of the drug.
In the treatment of acute and chronic urethritis and urethroprostatitis prescribed in combination with other drugs. The solution is injected into the urethra in a volume of 2-5 ml 2-3 times / day for 5-7 days.
To prevent infection of postpartum injuries, tampons moistened in 50 ml of solution with an exposure of 2 hours for 7 days are administered intravaginally.
For the prevention of sexually transmitted diseases, injected into the urethra men - 1.5-3 ml, women -1-1.5 ml; in the vagina - 5-10 ml for 2-3 minutes; process external genital organs, the skin of the pubis.
Adverse reactions
Local reactions: rarely - a burning sensation at the site of application (runs independently within 10-15 seconds and does not require discontinuation of the drug).
Contraindications
Hypersensitivity to the drug.
Drug interactions
With simultaneous use of the drug Miramistin with antibiotics, a decrease in the resistance of microorganisms to the latter was noted.
Pregnancy and Lactation
Perhaps the appointment of Miramistin during periods of pregnancy and lactation according to indications, since when applied topically and locally, systemic absorption of the active substance is unlikely.
AT experimental studies teratogenic and embryotoxic effect of the drug was not detected.
- Brand name: Miramistin
- Active ingredient: Benzyldimethyl 3- (myristoylamino) propylammonium chloride monohydrate
- Dosage form: Solution for local use 0.01%
- Manufacturer: Infamed
- Country of Origin: Russia
Studies and clinical trials of Miramistin (Click to expand)
- Keto-Enol tautomerization of quercetin in solutions of a cationic surfactant, miramistin
- Adsorption of a cationic surfactant, miramistin, from aqueous solutions on the surface of highly dispersed silica
- Cetylpyridinium chloride and miramistin as antiseptic substances in chronic wound management - prospects and limitations
- Supramolecular Structures in Nanosilica/Miramistin Hydrated Composite in a Hydrophobic Medium
- Effects of Miramistin and Phosprenil on Microbial Biofilms
- Interplay of noncovalent interactions in antiseptic quaternary ammonium surfactant Miramistin
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