Buy Dusopharm® pills 50 mg 90 pcs
  • Buy Dusopharm® pills 50 mg 90 pcs


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Clinical Pharmacology

Dusopharm has a vasodilating effect, as a result of which it improves peripheral and cerebral circulation. It causes a decrease in peripheral vascular resistance and increases the minute volume of the heart, without having a significant effect on heart rate and blood pressure. The vasodilating effect of Dusopharm is the result of its direct myotropic, antagonistic to serotonin 5HT2 receptors and alpha adreno-blocking action. It has an M-holinoblokiruyuschee effect. It has a positive effect on cellular metabolism, improving the utilization of oxygen and glucose. This action of the drug is due to its ability to increase ATP levels and inhibit the enzyme succinate dehydrogenase. It activates glucose utilization through the citric acid cycle and increases the conversion of succinic acid to fumaric acid. As a result, the resistance of cells (including the brain) to hypoxia increases. In addition, Dusopharm reduces increased blood viscosity.


The recovery period of cerebral circulation disorders; peripheral circulatory disorders (intermittent claudication, Raynaud's disease, trophic ulcers).


1 tablet contains: Active ingredient: naphthidrofuryl oxalate - 50 mg. Excipients: lactose monohydrate; microcrystalline cellulose; wheat starch; copovidone; colloidal silicon dioxide; magnesium stearate; talc. Shell composition: titanium dioxide; talc; magnesium stearate; macrogol 6000; methacrylic acid and ethyl acrylate copolymer; dye sunny sunset yellow E110.

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Dosage and Administration

For oral use. pills are taken whole, with enough liquid (it is recommended to drink water). In violation of cerebral circulation: a daily dose of 300 mg (2 pills 3 times a day). In case of violations of the peripheral circulation: daily doses - 500-600 mg, divided into 3 doses. Dusopharm is recommended for long-term oral therapy (up to 6 months). Dose adjustment for renal / hepatic failure is not required.

Adverse reactions

When taken orally in doses of 300 to 600 mg, Dusopharm is well tolerated as a whole. Possible side effects: nausea, vomiting, pain in the epigastric region, intestinal colic, diarrhea, loss of appetite, headache, dizziness, sleep disturbance, reversible increase in liver enzymes, gastric mucosa, allergic reactions.


Increased individual sensitivity to the drug. Myocardial infarction (acute stage). Hypotension. Hemorrhagic stroke (acute stage). Epilepsy, increased convulsive readiness. Chronic heart failure stage II – III (NYHA stage III – IV - functional classification of heart failure in the New York Heart Association). Tachyarrhythmias. Age up to 18 years (efficacy and safety have not been established). With care: angle-closure glaucoma; prostatic hyperplasia.

Drug interactions

Strengthens the hypotensive effect of antihypertensive drugs. In this regard, it is recommended more frequent control of blood pressure at the beginning of the combined treatment with Dusopharm and antihypertensive drugs at the same time.

Pregnancy and Lactation

Dusopharm does not have a teratogenic effect, but since special studies of its safety in pregnant women have not been conducted, it is recommended to prescribe the drug only in cases where the use of treatment for the mother outweighs the potential risk to the fetus. It is not recommended to take the drug during breastfeeding.


Symptoms: increased severity of side effects, ventricular arrhythmia, anxiety, low blood pressure, bradycardia. Treatment: gastric lavage, the appointment of Activated charcoal and laxatives, symptomatic treatment. There is no specific antidote.

  • Brand name: Dusopharm®
  • Active ingredient: Naftidrofuryl
  • Dosage form: pills
  • Manufacturer: Unipharm
  • Country of Origin: Bulgaria

Studies and clinical trials of Naftidrofuryl (Click to expand)

  1. Plasma concentrations and relative bioavailability of naftidrofuryl from different salt forms
  2. The effect of naftidrofuryl (Praxilene) on intermittent claudication
  3. Naftidrofuryl for ischaemic rest pain: A controlled trial
  4. Serotonin-induced contractility in human saphenous vein is inhibited by naftidrofuryl
  5. Isomerès optiques du naftidrofuryl ( = 2-[(naphth-1-yl)méthyl]-3-(tétrahydrofur-2-yl)propanoate de 2-(diéthylamino) éthyle)
  6. Rat cortex synaptic and nonsynaptic mitochondria: Enzymatic characterization and pharmacological effects of naftidrofuryl
  7. Naftidrofuryl protects the rat against chronic gastric ulceration
  8. Electrophysiological evaluation of the effects of naftidrofuryl on skeletal muscle reinnervation in the rat
  9. Experimental and clinical study of the effect of naftidrofuryl on the recovery from peripheral nerve lesions
  10. Determination of naftidrofuryl in human plasma by high-performance liquid chromatography with fluorescence detection
  11. Fatal intoxication with naftidrofuryl
  12. Use of cyclodextrins in isotachophoresis : III. Purity control of naftidrofuryl hydrogenoxalate and some of its synthesis intermediates
  13. Effects of naftidrofuryl oxalate on microsphere-induced changes in acetylcholine and amino acid content of rat brain regions
  14. Effect of naftidrofuryl on metabolism and survival of cultured neurons
  15. Effect of naftidrofuryl on lipid peroxidation in serum and erythrocyte plasma membrane of patients with diabetes mellitus
  16. Naftidrofuryl bij claudicatio intermittens: een meta-analyse
  17. Determination of naftidrofuryl in the plasma of humans by high-performance liquid chromatography
  18. Blood flow changes with naftidrofuryl in systemic sclerosis and Raynaud's phenomenon
  20. Effects of Naftidrofuryl on Local Cerebral Glucose Utilization in the Rat
  22. A validated HPLC method for the simultaneous determination of naftidrofuryl oxalate and its degradation product (metabolite), naftidrofuryl acid: applications to pharmaceutical tablets and biological samples
  23. Der Einfluß von Naftidrofuryl (Dusodril) auf die schallgeschädigten Summenaktionspotentiale des Hörnerven beim Meerschweinchen
  24. Postischemic breakdown in hippocampal protein synthesis and mnesic deficits in rats: Pharmacological improvement by curative naftidrofuryl treatment

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