Naftifine
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2019-09-19
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Clinical Pharmacology
Naftifine - the active substance of Micoderil - antifungal agent belonging to the class of allylamino. The mechanism of its action is due to the ability to inhibit squalene-2,3-epoxidase, as a result of which the formation of ergosterol, which is part of the cell wall of the fungus, is reduced. Naftifine affects squalene epoxidase and does not affect the cytochrome P450 system. The drug is active against mold fungi (Aspergillus), dermatophytes (Microsporum, Epidermophyton, Trichophyton), yeast and yeast-like fungi (Candida spp., Pityrosporum), as well as some other types of fungi (eg, Sporothrix schenckii). Dermatophytes and mold fungi naftifine acts fungicide, yeast fungi, depending on the strain of the microorganism, have a fungicidal or fungistatic effect. It has antibacterial activity against gram-negative and gram-positive microorganisms that cause the development of secondary bacterial infections. Due to the anti-inflammatory properties of the drug contributes to the rapid disappearance of symptoms of inflammation, especially itching.
Indications
- fungal infections of smooth skin and skin folds (tinea corporis, tinea inquinalis);
- interdigital mycoses (tinea manum, tinea pedum);
- fungal infections of the nails (onychomycosis);
- candidiasis of the skin;
- pityriasis versicolor;
- dermatomycosis (with or without itching).
Composition
1 g cream: active ingredient: naftifine hydrochloride - 10 mg;
additional components: isopropyl myristate - 80 mg, cetostearyl alcohol - 80 mg, polysorbate 60 - 61 mg, cetyl palmitate - 20 mg, sorbitan stearate - 19 mg, benzyl alcohol - 10 mg, sodium hydroxide - 1.2 mg, purified water - up to 1000 mg.
Naftifine is marketed under different brands and generic names, and comes in different dosage forms:
| Brand name | Manufacturer | Country | Dosage form |
|---|---|---|---|
| Mycoderil® | Lecco/Pharmstandard | Russia | cream |
| Mizol | solution | ||
| Exoderil | Sandoz | Switzerland | solution |
| Mycoderil® | Pharmstandard | Russia | solution |
| Mycoderil® | Pharmstandard | Russia | vials |
| Exoderil | Sandoz | Switzerland | cream |
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Dosage and Administration
Topically.
With skin lesions, Micoderil is applied 1 time / day to the affected skin surface and areas adjacent to it, after thorough cleaning and drying (capturing approximately 1 cm of healthy skin at the edges of the affected area).
The duration of treatment for ringworms is 2-4 weeks (up to 8 weeks if necessary), and candidiasis 4 weeks.
With the defeat of nails, Micoderil is applied 2 times / day on the affected nail. Before the first use of the drug, the affected part of the nail is removed as much as possible with scissors or a nail file.
The duration of therapy for opiochomycosis is up to 6 months.
To prevent recurrence, treatment should be continued for at least 2 weeks after the disappearance of the clinical symptoms.
Adverse reactions
Reactions may occur at the site of application: dry skin, skin flushing and burning. Side effects are reversible and do not require discontinuation of treatment. If any of the side effects indicated in the instructions are aggravated, or any other side effects that are not indicated in the instructions are noted, you should immediately inform your doctor.
Contraindications
- hypersensitivity to naftifine, benzyl alcohol or other components of the drug;
- pregnancy and lactation (the safety and efficacy of the drug in this category of patients has not been studied).
With care: children's age (experience of clinical use is limited).
Drug interactions
Interaction Microderil with its simultaneous use with other drugs is not marked.
Pregnancy and Lactation
The safety profile of naftifine in its use during pregnancy and lactation has not been studied, so Microderil is contraindicated for women during these periods of life.
Special instructions
According to the instructions, Micoderil is not intended for use in ophthalmology. Drug treatment is carried out courses. When applying the ointment / solution should be careful not to allow them to fall on open wounds.
- Brand name: Mycoderil®
- Active ingredient: Naftifine
- Dosage form: Cream for external use 1% white, uniform, with a slight specific smell.
- Manufacturer: Lecco / Pharmstandard
Studies and clinical trials of Naftifine (Click to expand)
- Azole Antifungal Agents Related to Naftifine and Butenafine
- ChemInform Abstract: Azole Antifungal Agents Related to Naftifine and Butenafine.
- A One-Pot Oxidation—Imine Formation—Reduction Route from Alcohols to Amines Using Manganese Dioxide—Sodium Borohydride: The Synthesis of Naftifine.
- ChemInform Abstract: Naftifine-Analogues as anti-Trypanosoma cruzi Agents.
- ChemInform Abstract: Substrate-Directable Heck Reactions with Arenediazonium Salts. The Regio- and Stereoselective Arylation of Allylamine Derivatives and Applications in the Synthesis of Naftifine and Abamines.
- Naftifine-analogues as anti-Trypanosoma cruzi agents
- A one-pot oxidation–imine formation–reduction route from alcohols to amines using manganese dioxide–sodium borohydride: the synthesis of naftifine
- Characterization of Complexes Between Naftifine and Cyclodextrins in Solution and in the Solid State
- Morphological Changes Induced by Naftifine, a New Antifungal Agent, in Trichophyton mentagrophytes.
- Allergic contact dermatitis to naftifine
- Modification of neutrophil functions by naftifine
- Does naftifine have anti-inflammatory properties? A double-blind comparative study with 1% clotrimazole/1% hydrocortisone in clinically diagnosed fungal infection of the skin
- Double-Blind Randomized Comparative Study of Naftifine Cream and Clotrimazole Cream in the Treatment of Dermatophytosis
- Once-Daily Naftifine Cream 1% in the Treatment of Tinea Cruris and Tinea Corporis
- Naftifine Cream 1% Compared with Miconazole Cream 2% in Dermatophytosis
- Naftifine Treatment for Dermatophytosis : Multicenter Clinical Investigations in Turkey
- Naftifine Treatment of Resistant Dermatophytosis
- Naftifine Treatment of Trichomycosis Pubis
- NAFTIFINE TREATMENT FOR DERMATOPHYTOSIS: MULTICENTER CLINICAL INVESTIGATIONS IN TURKEY : TURKISH MULTICENTER DERMATOPHYTOSIS STUDY GROUP
- COMPARATIVE EFFICACY OF NAFTIFINE, OXICONAZOLE, AND TERBINAFINE IN SHORT-TERM TREATMENT OF TINEA PEDIS
- Allergic contact dermatitis from naftifine in a child without cross-reaction to terbinafine
- Allergic contact dermatitis from naftifine
- ChemInform Abstract: Antifungal Agents. Part 11. Biphenyl Analogues of Naftifine: Synthesis and Antifungal Activities.
- Dermatomykosebehandlung mit Naftifin Therapeutische Wirksamkeit nach einmal und zweimal täglicher Applikation Treatment of Dermatomycoses with Naftifine Therapeutic Efficacy after Once-a-day and Twice-a-day Application
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