Buy Naftizin drops 0.05%, 15 ml
  • Buy Naftizin drops 0.05%, 15 ml

Naftizin® [Naphazoline]

Slavic pharmacy
1493 Items
2019-09-19
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$22.50
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Clinical Pharmacology

Naftizin - alpha-adrenostimuliruyuschee means, has a fast, pronounced and prolonged vasoconstrictor effect against the vessels of the mucous membranes (reduces swelling, hyperemia, exudation). Relieves nasal breathing in rhinitis. After 5-7 days, tolerance arises.

Indications

Acute rhinitis, allergic rhinitis, sinusitis, eustachitis, laryngitis, laryngeal edema of allergic origin, laryngeal edema during irradiation, hyperemia of the mucous membrane after operations on the upper respiratory tract, chronic conjunctivitis, asthenoptic disorders, as an auxiliary drug - in conjunctivitis of bacterial origin. To stop nasal bleeding, to facilitate rhinoscopy.

Composition

Active ingredient: naphazoline 500 mcg.

Naphazoline is marketed under different brands and generic names, and comes in different dosage forms:

Brand nameManufacturerCountryDosage form
Naftizin Slavic pharmacy Russia drops
Naftizin Grotex Ltd Russia drops
Sigida cristall Grotex Ltd Russia eye drops
Naftizin PFK Obnovlenie Russia drops
Naftizin DAV Farm Ltd Russia drops
Naftizin Slavic pharmacy Russia spray
Naftizin Lecco Russia drops
Naftizin Doctor Russia spray
Sanorin Teva Czech Enterprises sr.o Czech spray
Sanorin Teva Czech Enterprises sr.o Czech drops
Sanorin Teva Czech Enterprises sr.o Czech butter

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Naftizin® [Naphazoline]

Dosage and Administration

In otolaryngology: intranasal (in each nasal passage), adults are prescribed 1-3 cap 0.05-0.1% solution 3-4 times a day. In children, 0.05% aqueous solution (or 0.025% solution is used, diluting 0.05% solution with distilled water): from 1 to 6 years - 1-2 drops, from 6 to 15 years - 2 drops 1-3 times a day. For diagnostic purposes, after cleaning the nose, instill 3-4 drops in each nasal passage or insert a tampon dipped in 0.05% aqueous solution and leave for 1-2 minutes; With swelling of the vocal cords, inject 1-2 ml of solution in the form of a spray or in small doses with a laryngeal syringe; for bleeding, swabs moistened with a 0.05% solution. In ophthalmology: 1-2 cap 0.05% solution in the cavity of the conjunctiva, 1-3 times a day. As an additional drug for surface anesthesia - 2-4 cap per 1 ml of local anesthetic.

Adverse reactions

Nausea, tachycardia, headache, increased blood pressure, reactive hyperemia, swelling of the nasal mucosa. Irritation, when used for more than 1 week - swelling of the mucous membrane of the nasal cavity, atrophic rhinitis.

Contraindications

Hypersensitivity; arterial hypertension, marked atherosclerosis, thyrotoxicosis, children's age (up to 1 year), chronic rhinitis, serious eye diseases, diabetes mellitus; simultaneous administration of MAO inhibitors and a period of up to 14 days after the end of their use.

Drug interactions

It should not be used simultaneously with MAO inhibitors or within 10 days after the end of their use. Slows down the absorption of local anesthetic drugs (lengthens their action during surface anesthesia).

Pregnancy and Lactation

Not contraindicated.

Special instructions

May have a resorptive effect. The solution of the drug is acceptable to sterilize (after removing the drip closure and gasket) in saturated water vapor at a temperature of 115-116 degrees C for 30 minutes. With prolonged use, the severity of the vasoconstrictor action gradually decreases (the phenomenon of tachyphylaxis), and therefore it is recommended to take a break for several days after 5-7 days of use.

Overdosage

Symptoms: decrease in body temperature, bradycardia, increased blood pressure. Treatment: symptomatic.

  • Brand name: Naftizin®
  • Active ingredient: Naphazoline
  • Dosage form: Spray

Studies and clinical trials of Naphazoline (Click to expand)

  1. Selective solid-phase extraction of naphazoline using imprinted polymers as matrix prepared by precipitation polymerization
  2. Online naphazoline quality control by micellar-enhanced spectrofluorimetry
  3. Determination of naphazoline in rat plasma using column liquid chromatography with ultraviolet detection
  4. Two examples of rapid and simple drug analysis in pharmaceutical formulations using capillary electrophoresis: Naphazoline, dexamethasone and benzalkonium in nose drops and nystatin in an oily suspension
  5. Influence of the ageing phenomenon on the low-frequency electrical impedance behavior of naphazoline hydrochloride solutions and paracetamol syrup
  6. Spectrophotometric analysis of binary mixtures of antazoline and naphazoline
  7. Utility of chloranil in assay of naphazoline, clemizole, penicillin G sodium, and piperazine
  8. High-performance liquid chromatographic stability-indicating assay for naphazoline and tetrahydrozoline in ophthalmic preparations
  9. Synthesis and identification of the primary degradation product in a commercial ophthalmic formulation using NMR, MS, and a stability-indicating HPLC method for antazoline and naphazoline
  10. Chromatographic separation and analysis of naphazoline and its hydrolytic degradation products
  11. Kinetics of the specific base-catalyzed hydrolysis of naphazoline
  12. Determination of prednisolone, naphazoline, and phenylephrine in local pharmaceutical preparations by micellar electrokinetic chromatography
  13. Topical naphazoline in the treatment of myasthenic blepharoptosis
  14. Simultaneous determination of dibucaine and naphazoline in human serum by monolithic silica spin column extraction and liquid chromatography–mass spectrometry
  15. A fluorescence optosensor for analyzing naphazoline in pharmaceutical preparations: Comparison with other sensors
  16. A novel naphazoline-selective membrane sensor and its pharmaceutical applications
  17. Naphazoline intoxication in a child—a clinical and forensic toxicological case
  18. Simultaneous determination of naphazoline, diphenhydramine and phenylephrine in nasal solutions by capillary electrophoresis
  19. Crystal structures of two therapeutically active 2-imidazolines: naphazoline nitrate and tymazoline hydrochloride monohydrate
  20. Structure of naphazoline nitrate
  21. Comparison of three different phosphorescent methodologies in solution for the analysis of naphazoline in pharmaceutical preparations
  22. Naphazoline intoxication in children
  23. Intranasal lidocaine plus naphazoline nitrate improves surgical conditions and perioperative analgesia in septorhinoplasty surgery
  24. Allergic contact dermatitis from dibucaine hydrochloride, chlorpheniramine maleate, and naphazoline hydrochloride in an over-the-counter topical antiseptic

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