Naproxen

Brand Krka dd Novo mesto AO

In stock 829 Items

Available since: 2019-09-19

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Clinical Pharmacology

Pharmacotherapeutic group - nonsteroidal anti-inflammatory drug.

ATX Code: M01AE02

Pharmacological properties.

Bonifen forte, is a drug of naproxen, has analgesic, antipyretic and anti-inflammatory effects. The mechanism of action is associated with non-selective inhibition of the activity of cyclooxygenase 1 and 2 (COX-1, COX-2). Film-coated pills, Bonifen forte dissolves well, is quickly absorbed from the gastrointestinal tract and provides a quick onset of anesthetic effect.

Pharmacokinetics

Absorption from the gastrointestinal tract - fast and complete, bioavailability - 95% (food intake practically does not affect either the fullness or the rate of absorption). The time to reach the maximum concentration is 1-2 hours, the association with plasma proteins is> 99%, the half-life is 12-15 hours. Metabolism is in the liver to dimethylnaproxen with the participation of the CYP2C9 enzyme system. Clearance - 0.13 ml / min / kg. It is displayed on 98% of the kidneys, 10% of them are displayed in unchanged form; with bile - 0.5-2.5%. Equilibrium concentration is determined to receive 4-5 doses of the drug (2-3 days). In renal failure, accumulation of metabolites is possible.

Indications

Diseases of the musculoskeletal system (rheumatoid arthritis, psoriatic, juvenile chronic arthritis, ankylosing spondylitis (ankylosing spondylitis), gouty arthritis, rheumatic soft tissue, osteoarthritis of peripheral joints and spine, including radicular syndrome, tendonitis, bursitis)

Composition

1 tablet, film coated, contains:

CORE:

Active ingredient: naproxen sodium 550 mg.

Excipients: it looks like microcrystalline cellulose, talc, magnesium stearate, purified water.

Shell: Opadry dye YS-I-4216 (this ready-to-use mixture of titanium dioxide (171), macrogol, indigo carmine dye (E 132) and hypromellose.

Naproxen is marketed under different brands and generic names, and comes in different dosage forms:

Brand name	Manufacturer	Country	Dosage form
Bonifen	Krka dd Novo mesto AO	Slovenia	pills
			pills

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Dosage and Administration

For oral use. Strictly follow the instructions of the doctor. You should not stop treatment or change the dosage without first consulting a doctor. Ask your doctor about the duration of use of the drug.

Adverse reactions

Side effects are most frequent with high doses of Bonifen forte:

Contraindications

Hypersensitivity to naproxen or naproxen sodium; with anamnestic data on the attack of bronchial obstruction, rhinitis, urticaria after taking acetylsalicylic acid or other NSAIDs (complete or incomplete intolerance syndrome of acetylsalicylic acid - rhinosinusitis, urticaria, nasal mucosa polyps, asthma);

Drug interactions

When treating with anticoagulants it should be borne in mind that naproxen may increase bleeding time. Do not use the drug at the same time as other NSAIDs (increased risk of side effects). Patients who simultaneously receive hydantoins, anticoagulants, or other drugs that bind to a large extent with plasma proteins, should monitor signs of potentiation of the action or overdose of these drugs. The drug Bonifen forte may reduce the antihypertensive effect of propranolol and other beta-blockers, and may also increase the risk of renal failure associated with the use of ACE inhibitors. Under the action of naproxen, the natriuretic effect of furosemide is inhibited. Inhibition of renal clearance of lithium leads to an increase in plasma lithium concentrations. Taking probenecid increases the level of naproxen in the plasma. Cyclosporine increases the risk of developing renal failure. Naproxen slows the excretion of methotrexate, phenytoin, sulfonamides, increasing the risk of their toxic action. Antacid preparations containing magnesium and aluminum reduce naproxen absorption. It is necessary to inform your attending physician if you suffer from other diseases or allergies, or are taking any other medicines (including over-the-counter medication).

Pregnancy and Lactation

Bonifen forte is not recommended for use during pregnancy and lactation.

Special instructions

Do not exceed the doses indicated in the instructions. To reduce the risk of developing adverse events from the gastrointestinal tract (GIT), a minimum effective dose should be used with the shortest possible short course. If the pain and fever persist or become stronger, consult a doctor. Patients with bronchial asthma, with bleeding disorders, as well as patients with hypersensitivity to other analgesics before taking Forgesin forte should consult with your doctor. Caution should be given to patients with liver disease and renal failure. In patients with renal insufficiency, it is necessary to control the level of creatinine clearance. At the level of creatinine clearance below 20 ml / min: Naproxen is not recommended. In chronic alcohol and other forms of cirrhosis, the concentration of unbound naproxen increases, so lower doses are recommended for these patients. Bonifen forte should not be taken together with other anti-inflammatory and analgesic drugs, with the exception of doctor's prescriptions. Older patients are also recommended lower doses.

Overdosage

A significant overdose of the drug can be characterized by drowsiness, dyspeptic disorders (heartburn, nausea and vomiting, abdominal pain), weakness, tinnitus, irritability, in severe cases - bloody vomiting, melena, impaired consciousness, convulsions and renal failure).

A patient who has taken a randomly or deliberately large amount of Bonifen forte requires flushing the stomach and symptomatic therapy: activated charcoal, antacids, h2 receptor blockers, proton pump inhibitors. Hemodialysis is ineffective.