Buy Pimafucin suppositories 100 mg, 3 pcs
  • Buy Pimafucin suppositories 100 mg, 3 pcs


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Clinical Pharmacology

Pimafucin - fungicidal, antifungal.


Natamycin irreversibly binds to the sterols of the fungal cell membranes, violating the integrity and function, which leads to the death of microorganisms.

Natamycin is sensitive to most pathogenic yeasts, especiallyCandida albicans. Dermatophytes are less sensitive to natamycin. Primary resistance to natamycin is not found in clinical practice.


Natamycin has only local action, not being absorbed from the gastrointestinal tract, through the skin and mucous membranes.


Vaginitis, vulvitis, vulvovaginitis, caused mainly by fungiCandida.


1 suppository contains:

Active substance: natamycin100 mg;

Excipients: cetyl alcohol - 690 mg; solid fat - 700 mg; sorbitol - 460 mg; polysorbate 80 - 460 mg; sodium bicarbonate - 69 mg; adipic acid - 64 mg.

Natamycin is marketed under different brands and generic names, and comes in different dosage forms:

Brand nameManufacturerCountryDosage form
Pimafucin Astellas Netherlands suppositories
Pimafucin Astellas Netherlands cream
Ecofucin AVVA RUS Russia suppositories
Primafungin Anzhero-Sudzhensky HFZ Russia suppositories

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Dosage and Administration

When vaginitis, vulvitis, vulvovaginitis- 1 suppository for 3-6 days. The suppository is introduced into the vagina in the "lying" position, as deeply as possible, 1 time per day at night. With persistent vaginitis caused byCandida albicansadditionally prescribed Pimafucin in the form of pills for oral administration (1 tablet 4 times a day for 10–20 days) for the rehabilitation of a nidus of candidal infection in the intestine. For the treatment of candidal affection of the genital organs of the partner, Pimafucin in the form of a cream is used. The duration of treatment is set individually. After the disappearance of the symptoms of the disease, it is recommended to continue treatment for several days.

Adverse reactions

From the digestive tract: In some cases, the use of enteric pills, especially in the first days of treatment, may cause nausea and diarrhea, usually on their own.

Local reactions: perhaps slight irritation, burning sensation (when applying a cream, vaginal suppositories).


Hypersensitivity to the drug.

Pregnancy and Lactation

Perhaps the use of Pimafucin during pregnancy and lactation according to indications.

Special instructions

Vaginal suppositories under the action of body temperature quickly dissolve, forming a foamy mass, which contributes to the uniform distribution of the active substance.


To date, no cases of overdose of the drug Pimafucin have been reported. Prolonged use of Pimafucin does not adversely affect the skin or mucous membranes and the systemic effect is practically excluded. Accidental ingestion of a large amount of the drug should not cause any toxic effect, since absorption from the intestine is absent.

  • Brand name: Pimafucin
  • Active ingredient: Natamycin
  • Dosage form: Vaginal suppositories.
  • Manufacturer: Astellas
  • Country of Origin: Netherlands

Studies and clinical trials of Natamycin (Click to expand)

  1. Optimization of the cultivation medium for natamycin production by Streptomyces natalensis
  2. Untersuchung der Stabilität von Nystatin und Natamycin mit Hilfe der UV-Spektrophotometrie
  3. Preparation and characterisation of natamycin: γ-cyclodextrin inclusion complex and its evaluation in vaginal mucoadhesive formulations
  4. Effects of cultivation conditions on the production of natamycin with Streptomyces gilvosporeus LK-196
  5. Development of an RP-HPLC method for the simultaneous determination of benzoic acid, sorbic acid, natamycin and lysozyme in hard and pasta filata cheeses
  6. Polymer films releasing nisin and/or natamycin from polyvinyldichloride lacquer coating: Nisin and natamycin migration, efficiency in cheese packaging
  7. Bioanalytical method development and validation of natamycin in rabbit tears and its application to ocular pharmacokinetic studies
  8. A synthetic and in silico study on the highly regioselective Diels–Alder reaction of the polyenic antifungal antibiotics natamycin and flavofungin
  9. Evaluation of a selective medium for Brucella isolation using natamycin
  10. Cytotoxicity in pig hepatocytes induced by 8-quinolinol, chloramine-T and natamycin
  11. Development and evaluation of antimicrobial natamycin-incorporated film in gorgonzola cheese conservation
  12. Optimal efficacy of a fungicide preparation, natamycin, in the control of the house-dust mite,Dermatophagoides pteronyssinus
  13. Natamycin(R)
  14. A novel and rapid method for determination of natamycin in wines based on ultrahigh-performance liquid chromatography coupled to tandem mass spectrometry: validation according to the 2002/657/EC European decision
  15. Identification of a novelStreptomyces chattanoogensisL10 and enhancing its natamycin production by overexpressing positive regulator ScnRII
  16. Evaluation of a chitosan-based edible film as carrier of natamycin to improve the storability of Saloio cheese
  17. A controlled trial of house dust mite eradication using natamycin in homes of patients with atopic dermatitis: effect on clinical status and mite populations
  18. A controlled-trial of house dust mite eradication using natamycin in homes of patients with atopic dermatitis
  19. House dust mite allergen levels and an anti-mite mattress spray (natamycin) in the treatment of childhood asthma
  20. Whey Protein Film Composition Effects on Potassium Sorbate and Natamycin Diffusion
  21. Physical properties of biopolymers containing natamycin and rosemary extract
  22. Antifungal activity of biopolymers containing natamycin and rosemary extract against Aspergillus niger and Penicillium roquefortii
  23. Effect of biopolymers containing natamycin against Aspergillus niger and Penicillium roquefortii on fresh kashar cheese

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