Neovir [Cridanimod]
Pharmsynthez PAO
540 Items
2019-09-19
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Clinical Pharmacology
Immunostimulating drug. It has antiviral activity against DNA and RNA genomic viruses. It has a pronounced anti-Chlamydia effect. The activity of the drug is associated with its ability to induce the formation in the body of high titers of endogenous interferons, especially interferon alpha.
IM administration of Neovir at a dose of 250 mg for the detected serum concentrations of interferon is equivalent to the administration of 6-9 million IU of recombinant interferon alpha.
Neovir activates bone marrow stem cells, T lymphocytes and macrophages. Shows immunomodulating activity, normalizing the balance between subpopulations of T-helper and T-suppressor cells. In a number of diseases, Neovir is able to reduce the production of tumor necrosis factor in the body (HIV infection, herpes) and activate natural killer cells (for tumor diseases). Significantly increases the activity of polymorphonuclear leukocytes.
In case of HIV infection, Neovir has an immunomodulating effect: it increases the absorptive activity of blood serum, increases the ability of white blood cells to synthesize interferon alpha, and stimulates the formation of active oxygen forms by phagocytes.
The peak of interferon activity in the blood and tissues is observed several hours after Neovir administration and lasts for 16-20 hours.
Indications
As an immunostimulating agent in the combination therapy:
- prevention and treatment of influenza and other acute respiratory diseases (including against the background of immunodeficiency states);
- infections caused by the virus Herpes simplex type 1 and 2 and the virus Varicella zoster (including in persons with impaired immune systems);
- cytomegalovirus infection in persons with immunodeficiency;
- radiation immunodeficiency;
- treatment of HIV infection;
- viral etiology encephalitis and encephalomyelitis;
- acute and chronic hepatitis B and C;
- urethritis, epididymitis, prostatitis, cervicitis and salpingitis of chlamydial etiology;
- venereal lymphogranuloma;
- oncological diseases;
- multiple sclerosis;
- candidiasis of the skin and mucous membranes.
Composition
| 1 ml | |
| sodium oxodihydroacridinyl acetate | 125 mg |
Excipients: sodium citrate 2.5 mg, citric acid monohydrate 0.5-1.5 mg (up to pH 7.5-8.3), water d / and up to 1 ml.
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Dosage and Administration
The solution for injection is injected into the / m, a single dose of 250 mg (1 amp.) Or 4-6 mg / kg body weight. If necessary, a single dose of Neovir can be increased to 500 mg.
The course of treatment, unless specifically indicated, consists of 5-7 intramuscular injections in single doses with an interval of 48 hours. The course dose depends on the clinical picture. The course duration is 8-12 days. With prolonged and prophylactic use, the interval between injections of Neovir is 3-7 days.
In HIV infection, injection solution is used as part of a combination therapy. The course of treatment consists of 10 intramuscular injections of 250 mg each with an interval of 48 hours between injections. After the course of therapy, they take an interval of 2 months. The number of repeated courses is not limited.
Adverse reactions
General reactions: low-grade fever, allergic reactions.
Local reactions: local quickly passing pain at the injection site.
Contraindications
Use with caution in elderly patients.
Drug interactions
During clinical studies and the use of the drug in clinical practice, there have been no cases of incompatibility or potentiation of the drug when interacting with other drugs.
Information about the physico-chemical incompatibility of Neovir with other drugs is not available.
Pregnancy and Lactation
The drug is contraindicated for use during pregnancy and lactation (breastfeeding).
Special instructions
In case of poor tolerance or soreness in the place of intramuscular administration of the drug, it is recommended to administer Neovir together with 2 ml of 0.25-0.5% novocaine solution.
Overdosage
Data on drug overdose Neovir not provided.
- Brand name: Neovir
- Active ingredient: Cridanimode
- Dosage form: The solution for the / m introduction of a transparent, greenish-yellow color.
- Manufacturer: Pharmsynthez PAO
- Country of Origin: Russia
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