Nicotinic acid
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2019-09-19
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Clinical Pharmacology
Nicotinic acid is a specific anti-pellag agent.
Indications
- hypovitaminosis of PP, avitaminosis of PP (pellagra);
Composition
Active ingredient: nicotinic acid - 10 mg. Excipients: sodium bicarbonate - 7 mg, water for injection - up to 1 ml.
Nicotinic acid is marketed under different brands and generic names, and comes in different dosage forms:
| Brand name | Manufacturer | Country | Dosage form |
|---|---|---|---|
| Nicotinic acid | injection | ||
| pills | |||
| Nicotinic acid-SOLOpharm | Grotex Ltd | Russia | solution |
| Nicotinic Acid Bufus | PFK Obnovlenie | Russia | ampoules |
| Nicotinic Acid Bufus | PFK Obnovlenie | Russia | solution |
| Nicotinic acid | Zdorovye | Russia | ampoules |
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Dosage and Administration
Inside after eating. As an antipellargic agent, nicotinic acid is prescribed for adults at 0.1 g 2-4 times per day (the highest daily dose of 0.5 g).For children prescribed from 0.0125 to 0.05 g 2-3 times a day depending on age. The course of treatment is 15-20 days.
For adults for ischemic cerebral circulation disorders, vascular spasms of the limbs, gastritis with low acidity, neuritis of the facial nerve, wounds and ulcers, nicotinic acid is recommended to be administered in a single dose of 0.05-0.1 g - 1 month.
Adverse reactions
Redness of the face and upper half of the body (especially when taken on an empty stomach and in persons with hypersensitivity), dizziness, feeling of a rush of blood to the head, paresthesia, urticaria.
With the rapid on / in the introduction and with increased sensitivity - orthostatic hypotension.
With prolonged use - dystrophy of the liver, increased uric acid in the blood, reduced glucose tolerance.
Contraindications
- Hypersensitivity to the drug;
- peptic ulcer and 12 duodenal ulcers (in the acute stage);
- severe arterial hypertension;
- gout;
- hyperuricemia, nephrolithiasis, liver cirrhosis, decompensated diabetes mellitus.
- pregnancy and breastfeeding period.
- Active ingredient: Nicotinic acid
Studies and clinical trials of Nicotinic acid (Click to expand)
- Complex formation between aluminium(III) and 2-hydroxy nicotinic acid: an electrospray mass spectrometric investigation
- Pd0/PR3-Catalyzed Arylation of Nicotinic and Isonicotinic Acid Derivatives
- Chemical Synthesis of the Second Messenger Nicotinic Acid Adenine Dinucleotide Phosphate by Total Synthesis of Nicotinamide Adenine Dinucleotide Phosphate
- Pd0/PR3-Catalyzed Arylation of Nicotinic and Isonicotinic Acid Derivatives
- The kinetics of yeast growth and nicotinic acid production
- The kinetics of growth of Proteus vuigaris in nicotinic acid-limited cultures
- Determination of urinary tryptophan and its metabolites along the nicotinic acid pathway by high performance liquid chromatography with ultraviolet detection
- Neutral Chelate Lanthanide Complexes of 3-Hydroxy Pyridine-1-Oxide and Nicotinic Acid-1-Oxide
- Intensification of Nicotinic Acid Separation using Organophosphorous Solvating Extractants by Reactive Extraction
- Sodium Chains as Core Nanowires for Gelation of Organic Solvents from a Functionalized Nicotinic Acid and Its Sodium Salt
- ChemInform Abstract: Preparations and Applications of Nicotinic Acid and Nicotinamide
- ChemInform Abstract: Synthesis and Antibacterial Activity of Arylidene- and 5- Nitrofurfurylidenehydrazides of 2-Arylamino-5,6-trimethylene( tetramethylene)nicotinic Acid.
- ChemInform Abstract: Structure and Antiinflammatory Activity of Arylamides of Isonicotinic and Nicotinic Acid.
- ChemInform Abstract: Bioelectrochemically Accelerated Microbial Conversion of Nicotinic Acid to 6-Hydroxynicotinic Acid on Microorganism-Immobilized Column Electrolytic Flow System
- ChemInform Abstract: Light Induced Phototransformation of Nicotinic Acid with Laser and UV Light — A Comparative Study.
- ChemInform Abstract: Several Approaches to the Directed Search for Medicinal Drugs on the Basis of Nicotinic Acid
- ChemInform Abstract: Carbonic Anhydrase Inhibitors. Part 70. Synthesis and Ocular Pharmacology of a New Class of Water-Soluble, Topically Effective Intraocular Pressure Lowering Agents Derived from Nicotinic Acid and Aromatic/Heterocyclic Sulfonamides
- ChemInform Abstract: Michael Addition of Ethyl Acetoacetate to α,β-Unsaturated Oximes in the Presence of FeCl3: A Novel Synthetic Route to Substituted Nicotinic Acid Derivatives.
- ChemInform Abstract: Synthesis of Novel Derivatives of Pyrazolone [cf. (I)] and Nicotinic Acid [cf. (II)] and Their Effect on the Activity of Cytochrome P-450.
- ChemInform Abstract: Synthesis of Nicotinic Acid Derivatives by the Reaction of Salts of 1-Alkyl-4,6-dimethyl-2-pyrimidinylacetic Acid Esters with Amines.
- ChemInform Abstract: A Practical Synthesis of Nicotinic Acid Derivatives by Palladium on Charcoal.
- Diastereoselective Heterogeneous Catalytic Hydrogenation of 2-Methyl Nicotinic Acid Using Pyroglutamate Chiral Auxiliary.
- Preparation of Diastereomeric β-Aryloxymethylaminoalcohols Containing Nicotinic Acid Moiety and Their Binding Affinity to β3-Adrenoreceptors.
- Facile Synthesis of Nicotinic Acid Derivatives with Unsymmetrical Substitution Patterns.
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