Buy Cordiamine for injection ampoules 25%, 2 ml, 10 pcs
  • Buy Cordiamine for injection ampoules 25%, 2 ml, 10 pcs


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Clinical Pharmacology

Cordiamine - analeptic. It stimulates the central nervous system, stimulates the respiratory and vasomotor centers (especially when the vasomotor center is lowered). Direct stimulating effect on the heart and vasoconstrictor effect is not observed. In large (toxic) doses can cause clonic convulsions.


Violation of cardiac activity, shock, asphyxia; poisoning with narcotic, hypnotic drugs, analgesics.


1 ml solution for injection contains niketamida 0,25 g

Nikethamide is marketed under different brands and generic names, and comes in different dosage forms:

Brand nameManufacturerCountryDosage form
Cordiamine Dalkhimpharm Russia ampoules
Cordiamine Ellara Russia ampoules
Cordiamine Technopark Center Russia drops
Cordiamine Tatkhimpharmpreparaty Russia drops

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Dosage and Administration

P / c, IM, IV: adults - 1-2 ml 2-3 times a day. Higher doses for adults: single - 2 ml, daily - 6 ml. Introduction to the vein is done slowly.
In case of poisoning with drugs, hypnotics, analgesics - 3-5 ml. P / to and / m injection painful. To reduce pain, you can pre-enter procaine.
Children - s / c, 0.1-0.75 ml, depending on age.

Adverse reactions

Anxiety, muscle twitching (starting with the circular muscles of the mouth), flushing of the skin of the face, itching of the skin, vomiting, arrhythmias; infiltration and soreness at the injection site, allergic reactions.



Hypersensitivity, epilepsy, a history of tonic-clonic seizures, hyperthermia in children.

Drug interactions

The convulsive action of kordiamin enhances reserpine, the stimulating effect on the respiratory center is eliminated by means of anesthesia, the effect of the drug is weakened by PASK and salyuzid;

Pregnancy and Lactation


Special instructions

With Nikethamide overdose, convulsions are possible.


Information not described.

  • Brand name: Cordiamine for injection
  • Active ingredient: Nikethamide
  • Dosage form: Injection.
  • Manufacturer: Darchharm
  • Country of Origin: Russia

Studies and clinical trials of Nikethamide (Click to expand)

  1. Determination of nikethamide with cyanogen bromide and barbituric acid
  2. Simultaneous determination of nikethamide and lidocaine in human blood and cerebrospinal fluid by high performance liquid chromatography
  3. Effect of dextran on resistance of animals to infection and to the toxic action of nikethamide
  4. Comparative study of the action of long-term administration of nicotinic acid, nicotinamide, and diethylnicotinamide (nikethamide) on the rat liver mono-oxygenase system
  5. Effect of ephedrine and nikethamide on the outcome of microwave lesions in mice
  6. Effect of nikethamide on oxidative metabolsm of mitochondria in the rabbit cerebral cortex
  7. Effect of nikethamide on content of pyridine nucleotides in rabbit heart muscle
  8. Determination of nikethamide and n-ethylnicotinamide in the blood and urine of greyhounds
  10. Nikethamide for hiccough
  11. LC–MS–MS Determination of Nikethamide in Human Plasma
  12. The biotransformation of nikethamide in the rat and its acceleration by hexachlorocyclohexane
  13. Stabilization of nikethamide solution for injection with the aim of sterilization with ionizing radiation
  14. Potentiation of cathinone by caffeine and nikethamide
  15. Time of Day as a Factor influencing the Toxicity of Nikethamide.
  16. The Toxicity of Nikethamide at Different Times of the Day.
  17. The Effects of Nikethamide on the Blood Pressure after Paralysis of the Autonomic Ganglia with Hexamethonium Chloride.
  18. The Sedative and Lethal Actions of Reserpine in Mice, as Modified by 5-Hydroxytryptophan, 3,4-Dihydroxyphenylalanine, Methylphenidate, and Nikethamide in Cold and Warm Environments
  19. The effect of solvent polarity upon rotational barriers in nikethamide
  20. Solvent dependency of rotational barriers in ethamivan and comparison to nikethamide
  21. Effect of nikethamide on pentobarbital sleeping time in various animal species
  22. Effect of nikethamide on xenobiotic biotransformatiom in regenerating rat liver
  23. Modification of spinal transmission by nikethamide
  24. Effects of nikethamide, picrotoxin and strychnine on ‘amphetamine-state’

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