

Pharmacodynamics
Antimicrobial, 8-hydroxyquinoline derivative. It has a wide spectrum of action. Selectively inhibits the synthesis of bacterial DNA, forms complexes with metal-containing microbial cell enzymes.
Active in relation to:
Gram positive bacteria: Staphylococcus spp. (including Staphylococcus aureus); Streptococcus spp., Including: Beta-hemolytic streptococci; Streptococcus pneumoniae; Enterococcus faecalis; Corynebacterium spp; Bacillus subtilis.
Gram-negative bacteria: Escherichia coli; Proteus spp; Klebsiella spp; Salmonella spp; Shigella spp; Enterobacter spp; Haemophilus influenzae; Neisseria gonorrhoeae.
Other microorganisms: Ureaplasma urealyticum; Mycoplasma hominis; Mycobacterium tuberculosis; Trichomonas vaginalis.
Some types of mushrooms: candida, dermatophytes, mold fungi, some causative agents of deep mycoses.
Pharmacokinetics
Suction
Nitroxoline is well absorbed from the gastrointestinal tract (90%). WITHmax in plasma is reached in 1.5-2 hours after ingestion.
Metabolism and excretion
Metabolized in the liver. Excreted mainly by the kidneys unchanged and partially with bile. There is a high concentration of conjugated and unconjugated drug in the urine.
Treatment of acute, chronic and recurrent urinary tract infections caused by microorganisms sensitive to nitroxoline:
Prevention of infectious complications in the postoperative period:
Prevention of recurrent urinary tract infections.
1 coated tablet contains:
Active substance: nitroxoline - 50 mg.
Excipients: calcium phosphate, lactose monohydrate, corn starch, colloidal silicon dioxide, Povidone K25, purified talc, crospovidone, magnesium stearate.
Shell composition: acacia gum, carmellose sodium, povidone K25, sucrose, colloidal silicon dioxide, purified talcum, corn starch, calcium carbonate, titanium dioxide, sunset dye yellow E110, yellow quinoline E104.
Nitroxoline is marketed under different brands and generic names, and comes in different dosage forms:
Brand name | Manufacturer | Country | Dosage form |
---|---|---|---|
5-noc | Sandoz | Switzerland | pills |
Nitroxoline | Anzhero-Sudzhensky HFZ | Russia | pills |
No customer reviews for the moment.
For adults and adolescents: the standard dose is 400 mg / day, divided into 4 doses (2 pills, 4 times / day). The maximum dose is 800 mg / day.
Children older than 5 years: the average dose is 200-400 mg / day, divided into 4 doses.
Children 3-5 years old: the average dose is 200 mg / day, divided into 4 doses.
The course of treatment is 2-4 weeks, if necessary, the therapy is continued with intermittent courses (2 weeks during the month). pills should be taken before meals.
Application for violations of the liver
Patients with liver failure are recommended to use half the standard daily dose of the drug - 200 mg / (1 tablet 4 times / day).
Application for violations of renal function
Patients with moderate renal insufficiency (QC more than 20 ml / min) are recommended to use half of the standard daily dose of the drug - 200 mg / (1 tablet 4 times / day).
From the digestive system: nausea, vomiting (can be prevented by taking the drug during a meal), increased activity of hepatic transaminases.
From the side of the central nervous system and peripheral nervous system: ataxia, headache, paresthesia, polyneuropathy.
Since the cardiovascular system: tachycardia.
Allergic reactions: skin rash.
Other: thrombocytopenia, increased serum uric acid levels.
Not described.
Contraindicated in pregnancy and lactation (breastfeeding).
It should not be prescribed simultaneously with drugs containing hydroxyquinolines or their derivatives.
When used in patients with impaired renal function due to the possible accumulation of the drug, medical supervision is necessary.
You should not assign treatment for more than 4 weeks without additional examination of the liver and kidneys.
During treatment with nitroxoline, urine is stained an intense yellow-red color.
Impact on the ability to drive vehicles and other mechanisms that require high concentration of attention
There is no data on the effect on the ability to drive a car or machinery.
There is no data on overdose or clinical signs of nitroxolin poisoning.
Studies and clinical trials of Nitroxoline (Click to expand)