Nonoxynol
Amkafarm
895 Items
2019-09-19
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Clinical Pharmacology
Pharmacodynamics:
Nopoxypol is a non-ionic surface-active compound, its spermicidal effect is due to fragmentation and a decrease in sperm motility. It has bactericidal activity against gonococci and chlamydia. In vitro is active against HIV infections, but there are no clinical data on reducing the risk of HIV infection when using ponoxinol. Lactic acid has a beneficial effect on the normal microflora and vaginal mucosa.
When using a suppository, the concentration of ponoxinol in the vagina is on average 1-1.7%, which is sufficient for the manifestation of spermicidal activity.
The spermicidal action of the suppository occurs after its dissolution, approximately 10 minutes after insertion into the vagina, and lasts no more than 2 hours.
When using the drug does not form foam.
Pharmacokinetics:
Data on the pharmacokinetics of ponoxinol in humans are absent.
Indications
Local contraception.
Composition
Active substance: Nonoxynol-9 - 120 mg;
Excipients: D-, L-Lactic acid, macrogol 4000 (polyethylene oxide), macrogol 1000 (polyethylene oxide).
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Dosage and Administration
The suppository is inserted into the vagina as deep as possible, no less than 10 minutes and not earlier than 1 hour before the start of sexual intercourse. When re-sexual intercourse using a new suppository in the same way. After intercourse for 6 hours, it is not recommended to produce a toilet of the vagina in order to avoid loss of the contraceptive effect.
Adverse reactions
Rarely - dermatitis, itching, burning of the vagina of a woman or a penis partner.
Irritation usually passes without special measures.
Contraindications
- Hypersensitivity to the drug Nonoxynol components;
- cervical erosion;
- salingoophoritis;
- colpitis;
- vaginitis;
- abnormalities of the vagina, impeding the use of the drug.
Drug interactions
Because of the possible reduction in spermicidal activity, the drug Nonoxynol is not recommended for use with other drugs intended for intravaginal administration.
Pregnancy and Lactation
When pregnancy does not apply.
Can be used for contraception during breastfeeding.
Special instructions
When itching, use of the drug should be discontinued.
With frequent use of suppositories, the likelihood of side effects increases.
Use in combination with a condom is possible.
- Brand name: Nonoxynol
- Active ingredient: Nonoxynol
- Dosage form: Vaginal suppositories
- Manufacturer: Amkafarm
- Country of Origin: Germany
Studies and clinical trials of Nonoxynol (Click to expand)
- Mechanical properties of polyurethane film exposed to solutions of nonoxynol-9 surfactant and poly(ethylene glycol)
- In vitro BALB/3T3 cell transformation assay of nonoxynol-9 and 1,4-dioxane
- Use of rainbow trout primary epidermal cell cultures as an alternative to immortalized cell lines in toxicity assessment: A study with nonoxynol
- Preparation of [131I] iodinated nonoxynol-9
- A simple, sensitive assay for the spermicide nonoxynol-9 in biological fluids by high-performance liquid chromatography
- Analytical high-performance liquid chromatography system for separation of components in nonoxynol-9 spermicidal agents
- Effects of the spermicide nonoxynol-9 on the pregnant uterus and the conceptus of rat
- Determination of the spermicide nonoxynol-9 in vaginal lavage by high-performance liquid chromatography
- Preparative liquid chromatographic separation of the oligomers of nonoxynol-9 and their characterization by 1H-NMR and mass spectroscopy
- Contraceptive effectiveness and safety of five nonoxynol-9 spermicides: a randomized trial: Raymond EG, Chen PL, Luoto J, for the Spermicide Trial Group. Contraceptive effectiveness and safety of five nonoxynol-9 spermicides: A randomized trial. Obstet Gynecol 2004;103:430–9
- Nonoxynol-9 spermicide is not recommended for preventing sexually transmitted infections
- Nonoxynol-9 does not prevent sexually transmitted infections: Wilkinson D, Tholandi M, Ramjee G, Rutherford GW. Nonoxynol-9 spermicide for prevention of vaginally acquired HIV and other sexually transmitted infections: systematic review and meta-analysis of randomized controlled trials including more than 5000 women. Lancet Infect Dis 2002;2:613–7.
- Influence of the spermicidal compound nonoxynol-9 on the adhesion ofE. colito human epithelial cells
- Assessment of a new modified soft jelly capsule containing nonoxynol as spermicide contraceptive
- Influence of the spermicidal compound nonoxynol-9 on the growth and adhesion of urogenital bacteria in vitro
- Spermicidal effect of jieze No. 1 in combination with nonoxynol-9In vitro
- Awareness and Attitudes Regarding Microbicides and Nonoxynol-9 use in a Probability Sample of Gay Men
- Correlation between hydrophobicity and resistance to nonoxynol-9 and vancomycin for urogenital isolates of lactobacilli
- Allergic contact dermatitis due to nonylphenol ethoxylate (Nonoxynol-6)
- Allergic contact dermatitis from nonoxynol-12 in a polish
- Increased COX-2 Expression in Human Vaginal Epithelial Cells Exposed to Nonoxynol-9, a Vaginal Contraceptive Microbicide that Failed to Protect Women from HIV-1 Infection
- Comparative in vitro spermicidal activity of chelating agents and synergistic effect with nonoxynol-9 on human sperm functionality
- Genital transmission of HPV in a mouse model is potentiated by nonoxynol-9 and inhibited by carrageenan
- Quantitation of vaginally administered nonoxynol-9 (n9) in premenopausal women.
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