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Norbactin is an antibacterial agent from the group of fluoroquinolones. Has a bactericidal effect. It affects the bacterial enzyme DNA gyrase, which provides supercoiling and, thus, the stability of bacterial DNA. Destabilization of the DNA chain leads to the death of bacteria. It has a wide range of antibacterial action.
Bacterial infections of the urinary tract (pyelonephritis, cystitis, urethritis), genitals (prostatitis, cervicitis, endometritis), gastrointestinal tract (salmonellosis, shigellosis), uncomplicated gonorrhea. Prevention of infections in patients with granulocytopenia, travelers' diarrhea.
1 tablet contains 400 mg norfloxacin.
Norfloxacin is marketed under different brands and generic names, and comes in different dosage forms:
|Brand name||Manufacturer||Country||Dosage form|
|Norbactin||Ranbaxy Laboratories Ltd||India||pills|
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Dosage and Administration
Acute urinary tract infections - 400 mg twice a day for 7-10 days.
Acute uncomplicated cystitis - 400 mg twice a day for 3 days.
Recurrent or chronic infections of the urinary tract with exacerbations - 400 mg twice a day for 4 weeks, then, if necessary, 400 mg per day for up to 12 weeks.
There is evidence of a significant reduction in the frequency of recurrence of urinary tract infections in women with frequent recurrent infections with prophylactic administration of 200 mg of Norbactin once after sexual intercourse.
Chemoprophylaxis for urological interventions, surgeries and for postoperative infections - 400 mg twice a day before and after surgery, as needed.
Acute uncomplicated gonococcal infections - 800 mg once.
Bacterial intestinal infections - 400 mg twice a day for 5 days.
Prevention of travelers' diarrhea - 400 mg once a day (no more than 21 days). The widespread use of antibacterial agents for the prevention of diarrhea is not recommended, they can be used in high-risk areas, in the presence of aggravating factors (hypochlorhydria, the use of antacids and secretion inhibitors, dysgammaglobulinemia) and a high risk of complications due to dehydration in somatic diseases, diuretics, cardiac glycosides.
For better efficacy and tolerability, Norbactin should be taken one hour before or two hours after a meal. It can not be taken with antacids. Patients are advised to drink enough liquid to prevent crystalluria.
Patients with renal insufficiency (creatinine clearance from 10 to 30 ml / min / 1.73 m2) - 400 mg once a day.
Contraindicated in patients with anamnestic indications of hypersensitivity to norfloxacin or any other chemical analogue. It should not be used in patients with severe renal insufficiency (creatinine clearance less than 10 ml / min / 1.73 m2) and pregnant women.
Norbactin should be used with caution in patients with epilepsy, convulsive syndrome of a different etiology, with severe impaired renal function and liver. During treatment, patients should receive a sufficient amount of fluid (under the control of diuresis).
Norbactin should be taken no less than 2 hours before or 2 hours after taking antacids or preparations containing iron, zinc, magnesium, calcium or sucralfate.
- Brand name: Norbactin
- Active ingredient: Norfloxacin
- Dosage form: Pills.
- Manufacturer: Ranbaxy Laboratories Ltd
- Country of Origin: India
- Kinetic and mechanistic studies on the oxidation of Norfloxacin by Chloramine-B and N-Chlorobenzotriazole in acidic medium
- Crystallographic report: Bis(norfloxacin)dilead(II) tetranitrate, [Pb2(H-Norf)2(ONO2)4]
- Antibacterial activity of polymers with norfloxacin moieties against native and norfloxacin-tolerance-induced bacteria
- Preparation and application of Norfloxacin-MIP/polysulfone blending molecular imprinted polymer membrane
- A study on the micelle-sensitized Ce(IV)–Na2S2O3–norfloxacin chemiluminescence system and its applications
- Determination of norfloxacin using a terbium-sensitized electrogenerated chemiluminescence method
- Characterization of a new norfloxacin metabolite monitored during a bioequivalence study by means of mass spectrometry and quantum computation
- A high performance liquid chromatographic procedure for the simultaneous determination of norfloxacin and furprofen in rat plasma
- Quantitative separation of oxytocin, norfloxacin and diclofenac sodium in milk samples using capillary electrophoresis
- Development and validation of a fast isocratic liquid chromatography method for the simultaneous determination of norfloxacin, lomefloxacin and ciprofloxacin in human plasma
- A simple chromatographic method for determining norfloxacin and enoxacin in pharmacokinetic study assessing CYP1A2 inhibition
- High-throughput liquid-chromatography method with fluorescence detection for reciprocal determination of furosemide or norfloxacin in human plasma
- Adsorption of Norfloxacin from Aqueous Solution onto Modified Coal Fly Ash
- ChemInform Abstract: Synthesis, Antibacterial, Antifungal, and Anti-HIV Evaluation of Norfloxacin Mannich Bases.
- ChemInform Abstract: Synthesis, Antibacterial, Antifungal and Anti-HIV Activities of Norfloxacin Mannich Bases.
- ChemInform Abstract: Synthesis, Antibacterial, and Cytotoxic Evaluation of Certain 7-Substituted Norfloxacin Derivatives.
- New Carbohydrate Derivatives of Norfloxacin.
- ChemInform Abstract: One-Pot Synthesis of Norfloxacin Ethyl Ester from 3-Chloro-4-fluoroaniline in Ionic Liquid.
- ChemInform Abstract: Synthesis of Norfloxacin Analogues Catalyzed by Lewis and Broensted Acids: An Alternative Pathway.
- ChemInform Abstract: Synthesis and Antibacterial Evaluation of Novel 8-Fluoro Norfloxacin Derivatives as Potential Probes for Methicillin and Vancomycin-Resistant Staphylococcus aureus.
- ChemInform Abstract: Synthesis and Antimicrobial Activity of Thiazolidinone Norfloxacin Hybrids (VI).
- Solubilities of norfloxacin in ethanol, 1-propanol, acetone, and chloroform from 294.15 to 318.15 K
- Studies on the energy transfer system of terbium-norfloxacin chelate and its interaction with serum albumins
- Two Polymeric Complexes of Norfloxacin with Iron(II) and Their Magnetic Properties